1997
DOI: 10.1007/bf00941906
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Abstract: In idiopathic recurrent calcium urolithiasis (RCU) the state of insulin and carbohydrate metabolism, and relationships to minerals such as phosphate, are insufficiently understood. Therefore, in two groups of males with RCU (n = 30) and healthy controls (n = 8) the response to an oral carbohydrate- and calcium-rich test meal was studied with respect to glucose, insulin, and C-peptide in peripheral venous blood (taken before and up to 180 min post-load), and phosphate and glucose in fasting and post-load urine.… Show more

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Cited by 23 publications
(22 citation statements)
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“…Insulin resistance is associated with a reduction in renal ammonium production and low urinary pH, which could lead to the development of uric acid stones and oxalate calcium stones (8). It is reported that the compensatory hyperinsulinemia as a result of insulin resistance leads to an increase in urinary calcium excretion (9). A direct effect of hyperinsulinemia on urinary calcium excretion was also observed under the euglycemic condition (10), which could promote the formation of kidney stones containing calcium.…”
Section: Introductionmentioning
confidence: 80%
“…Insulin resistance is associated with a reduction in renal ammonium production and low urinary pH, which could lead to the development of uric acid stones and oxalate calcium stones (8). It is reported that the compensatory hyperinsulinemia as a result of insulin resistance leads to an increase in urinary calcium excretion (9). A direct effect of hyperinsulinemia on urinary calcium excretion was also observed under the euglycemic condition (10), which could promote the formation of kidney stones containing calcium.…”
Section: Introductionmentioning
confidence: 80%
“…Increased calcium absorption may enhance free oxalate in the intestinal lumen and increase oxalate absorption. According to Schwille et al [22]postprandial hyperinsulinemia was observed in idiopathic recurrent calcium urolithiasis. Postprandial hyperinsulinemia was probably caused by insulin resistance of organs including the kidney.…”
Section: Discussionmentioning
confidence: 99%
“…In contrast, Pi in postprandial urine was found to be increased in both hypercalciuric and unclassified (in terms of calciuria) RCU [41,44]. More specifically, in younger adults (mean age 29 years), post-test meal Pi-uria was not only high compared with controls, but was also accompanied by hyperinsulinemia and resistance of organs to the actions of insulin (synonymous insulin sensitivity).…”
Section: Introductionmentioning
confidence: 48%
“…More specifically, in younger adults (mean age 29 years), post-test meal Pi-uria was not only high compared with controls, but was also accompanied by hyperinsulinemia and resistance of organs to the actions of insulin (synonymous insulin sensitivity). In contrast, blood glucose dynamics were unremarkable, as was urinary glucose in postprandial urine [44]. Insulin, when administered acutely in metabolically healthy subjects matched for age, reduces Pi-uria and natriuresis, but stimulates calciuria [10].…”
Section: Introductionmentioning
confidence: 79%