Postpartum assessment of fetal inflammatory response syndrome in a preterm population with premature rupture of membranes: A Romanian study

Zaharie, Gabriela; Drugan, Tudor; Crivii, Carmen; Mureşan, Daniel; Zaharie, Alexandru; Hășmășanu, Monica; Zaharie, Flaviu; Matyas, Melinda

doi:10.3892/etm.2021.10862

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…In neonates born to mothers with PROM, NEC may be associated with an exaggerated inflammatory response involving the release of cytokines and chemokines, which can cause intestinal mucosal injury. A prospective case-control study has demonstrated elevated levels of IL-6, IL-10, and ENA-78 in the venous blood of newborns from mothers with PROM compared to normal controls ( 23 ).…”

Section: Discussionmentioning

confidence: 99%

Advancing necrotizing enterocolitis prediction through iterative monitoring

Dong,

Yin,

et al. 2024

Transl Pediatr

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Background Necrotizing enterocolitis (NEC) is a severe inflammatory intestinal disease in preterm infants, marked by heightened morbidity and mortality. Timely prediction of NEC is significant in the management of critical neonates. However, it is difficult to predict NEC accurately because of the multi-factorial pathogenesis. This study aimed to develop a prediction model through repeated measurement data to further improve the accuracy of prediction in NEC. Methods We retrospectively collected clinical data of premature infants admitted to the Neonatology Department of the First Affiliated Hospital of Anhui Medical University from January 2016 to December 2023. The infants were categorized into the NEC group (Bell’s stage ≥ II) (n=150) and the non-NEC group (n=150). The clinical baseline data of the NEC and non-NEC groups were matched. Laboratory examination indicators were collected on the 1st day, the 7th day after birth, and the day of NEC onset. Univariate and multivariate logistic regression analyses were conducted to identify independent factors influencing NEC. A nomogram was constructed based on these factors to predict NEC. The concordance index and calibration plot were used to assess the efficiency of the nomogram in the training and validation cohorts. Results This study demonstrated that antenatal steroids, antenatal antibiotics, probiotics treatment before NEC, anion gap (AG, day 7), and mean corpuscular volume (MCV, day 7) were independent risk factors which combined to accurately predict NEC. A nomogram of NEC was created utilizing these five predictors. With an area under the receiver operator characteristic (ROC) curve of 0.835 [95% confidence interval (CI): 0.785–0.884]. Concordance index for the training and validation groups were 0.835 and 0.848, respectively. As the calibration plots indicate, the predicted probability of NEC is highly consistent with the actual observation. Conclusions The risk estimation nomogram for NEC offers clinical value by guiding early prediction, targeted prevention, and early intervention strategies for NEC.

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Section: Discussionmentioning

confidence: 99%

Advancing necrotizing enterocolitis prediction through iterative monitoring

Dong,

Yin,

et al. 2024

Transl Pediatr

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“…Руйнування існуючих нейронів або втручання у міграцію або розвиток нових нейронів призводить до аберантного розвитку кори, аномального розвитку мозку з подальшими когнітивними та поведінковими порушеннями. Наявність незрілих олігодендроцитів і амебоїдної мікроглії в ділянці білої речовини мозку у кінці ІІ триместра може зумовити підвищену вразливість мозку до будь-яких патологічних процесів [20,21].…”

Section: синдром системной воспалительной реакции плода (клиническая ...unclassified

The Fetal Inflammatory Response Syndrome (Clinical lecture)

Zhuk

Shchurevska

2022

RHW

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The article highlights the problem of fetal inflammatory response syndrome (FIRS) in modern conditions. This term has been introduced into the clinical practice to describe the systemic activation of the innate or acquired immune system of the fetus. FIRS can occur in response to infection or inflammation and is divided into two types depending on the type of immune response. FIRS I and II types are different clinical syndromes and correspond to acute and chronic inflammatory processes.The main pathophysiological mechanisms and clinical features of different variants of FIRS are described. Fetuses with this syndrome have signs of multiorgan damage. The consequences of FIRS are a high rate of complications in newborns: sepsis, congenital pneumonia, intraventricular hemorrhage, periventricular leukomalacia, cerebral palsy, neurosensory deafness, necrotic enterocolitis and others. The detailed description of fetal organs and systems damage by FIRS is presented. In further life, such children are at risk of long-term complications. This syndrome can also be the cause of unexplained antenatal fetal death.Laboratory diagnostic criteria for FIRS type I include elevated levels of interleukin-6 and acute phase reagents. Histologically there are the signs of funiculitis or chorionic vasculitis.The marker of FIRS type II is the chemotactic chemokine CXCL10, which simulates maternal antifetal rejection.The article presents the basic mechanisms of the immune response in FIRS. In this type of pathology there are chronic inflammatory lesions of the placenta which are determined by histological study (chronic chorioamnionitis, vilitis of unknown etiology, chronic deciduitis).

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Postpartum assessment of fetal inflammatory response syndrome in a preterm population with premature rupture of membranes: A Romanian study

Cited by 2 publications

References 26 publications

Advancing necrotizing enterocolitis prediction through iterative monitoring

Advancing necrotizing enterocolitis prediction through iterative monitoring

The Fetal Inflammatory Response Syndrome (Clinical lecture)

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