Postoperative radiotherapy for non-small cell lung cancer

Abstract

Pechoux C, on behalf of the PORT Meta-analysis Trialists Group. Postoperative radiotherapy for non-small cell lung cancer.

The emerging outcome of postoperative radiotherapy for stage IIIA(N2) non-small cell lung cancer patients: based on the three-dimensional conformal radiotherapy technique and institutional standard clinical target volume

“…This detrimental effect was evident among patients who exhibited no mediastinal involvement, whereas in patients with stage III and pN2 disease, a slight increase in survival was detected, although the difference was not statistically significant. Similar results were found when this meta-analysis was updated in 2005 [ 5 ]. Recently, several large retrospective studies and a recently published randomized trial have provided evidence of the possible benefit of PORT in completely resected stage IIIA(N2) patients [ 7 - 13 ].…”

The emerging outcome of postoperative radiotherapy for stage IIIA(N2) non-small cell lung cancer patients: based on the three-dimensional conformal radiotherapy technique and institutional standard clinical target volume

“…This detrimental effect was evident among patients who exhibited no mediastinal involvement, whereas in patients with stage III and pN2 disease, a slight increase in survival was detected, although the difference was not statistically significant. Similar results were found when this meta-analysis was updated in 2005 [ 5 ]. Recently, several large retrospective studies and a recently published randomized trial have provided evidence of the possible benefit of PORT in completely resected stage IIIA(N2) patients [ 7 - 13 ].…”

The effect of postoperative radiotherapy on the survival of patients with resectable stage III-N2 non-small-cell lung cancer: a systematic review and meta-analysis

“…A meta-analysis based on individual patient data of 2,128 participants from 9 trials showed a significantly adverse effect of PORT on OS with an 7% lower survival rate at two years (48% vs. 55%) in patients with completely resected NSCLC, but did trend a possible benefit of survival in the pN2 subgroup [14]. Following update of this metaanalysis based on individual patient data of 2,343 participants from 11 trials demonstrated PORT decreased the survival rate at two years by 6% (53% vs. 58%) of the whole patient group, and the newest update published in 2010 with new trials came to the same conclusion [15,16].…”

The nomogram for the prediction of overall survival after surgery in patients in early‐stage NSCLC based on SEER database and external validation cohort

“… 27 Postoperative radiotherapy can't reduce the mortality in I stage NSCLC patients, but increase patient mortality, which is consistent with previous reports. 28 , 29 …”

The emerging outcome of postoperative radiotherapy for stage IIIA(N2) non-small cell lung cancer patients: based on the three-dimensional conformal radiotherapy technique and institutional standard clinical target volume

“…This detrimental effect was evident among patients who exhibited no mediastinal involvement, whereas in patients with stage III and pN2 disease, a slight increase in survival was detected, although the difference was not statistically significant. Similar results were found when this meta-analysis was updated in 2005 [ 5 ]. Recently, several large retrospective studies and a recently published randomized trial have provided evidence of the possible benefit of PORT in completely resected stage IIIA(N2) patients [ 7 - 13 ].…”

The effect of postoperative radiotherapy on the survival of patients with resectable stage III-N2 non-small-cell lung cancer: a systematic review and meta-analysis

“…A meta-analysis based on individual patient data of 2,128 participants from 9 trials showed a significantly adverse effect of PORT on OS with an 7% lower survival rate at two years (48% vs. 55%) in patients with completely resected NSCLC, but did trend a possible benefit of survival in the pN2 subgroup [14]. Following update of this metaanalysis based on individual patient data of 2,343 participants from 11 trials demonstrated PORT decreased the survival rate at two years by 6% (53% vs. 58%) of the whole patient group, and the newest update published in 2010 with new trials came to the same conclusion [15,16].…”

The nomogram for the prediction of overall survival after surgery in patients in early‐stage NSCLC based on SEER database and external validation cohort

“… 27 Postoperative radiotherapy can't reduce the mortality in I stage NSCLC patients, but increase patient mortality, which is consistent with previous reports. 28 , 29 …”

The emerging outcome of postoperative radiotherapy for stage IIIA(N2) non-small cell lung cancer patients: based on the three-dimensional conformal radiotherapy technique and institutional standard clinical target volume

“…This detrimental effect was evident among patients who exhibited no mediastinal involvement, whereas in patients with stage III and pN2 disease, a slight increase in survival was detected, although the difference was not statistically significant. Similar results were found when this meta-analysis was updated in 2005 [ 5 ]. Recently, several large retrospective studies and a recently published randomized trial have provided evidence of the possible benefit of PORT in completely resected stage IIIA(N2) patients [ 7 - 13 ].…”

The effect of postoperative radiotherapy on the survival of patients with resectable stage III-N2 non-small-cell lung cancer: a systematic review and meta-analysis

“…A meta-analysis based on individual patient data of 2,128 participants from 9 trials showed a significantly adverse effect of PORT on OS with an 7% lower survival rate at two years (48% vs. 55%) in patients with completely resected NSCLC, but did trend a possible benefit of survival in the pN2 subgroup [14]. Following update of this metaanalysis based on individual patient data of 2,343 participants from 11 trials demonstrated PORT decreased the survival rate at two years by 6% (53% vs. 58%) of the whole patient group, and the newest update published in 2010 with new trials came to the same conclusion [15,16].…”

The nomogram for the prediction of overall survival after surgery in patients in early‐stage NSCLC based on SEER database and external validation cohort

“… 27 Postoperative radiotherapy can't reduce the mortality in I stage NSCLC patients, but increase patient mortality, which is consistent with previous reports. 28 , 29 …”