Postoperative complications after vulvectomy and inguinofemoral lymphadenectomy using separate groin incisions

Gaarenstroom, Katja N.; Kenter, G.G.; Trimbos, J. Baptist; Agous, I.; Amant, Frédéric; Peters, A. C. B.; Vergote, I.

doi:10.1046/j.1525-1438.2003.13304.x

Cited by 250 publications

(97 citation statements)

References 14 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The SLNB concept has been adapted from other malignancies, reducing surgical mortality with slightly higher groin recurrence rates [15]. Lymphedema is one of the major complications after a ILND effecting up to 70% of the patients [20,21]. With removal of only SLN, lymph-edema rates dropped from 25.2 to 1.9 percent [20].…”

Section: Discussionmentioning

confidence: 99%

Comparison of Outcome after Sentinel Lymph Node Biopsy or Inguinal Lymph Node Dissection in Patients with Nodal Negative Squamous Vulvar Cancer

Ebner¹,

Antje²,

Schramm³

et al. 2017

Glob Surg

View full text Add to dashboard Cite

Sentinel lymph node biopsy (SLNB) can reduce postoperative morbidity in women with vulvar cancer but data on long-term outcome of SLNB compared to inguinal lymph node dissection (ILND) is rare. Recurrence rates, disease-free survival (DFS) and overall survival (OS) from pT1/T2 pN0 squamous vulvar cancer from 1992 -2011 were retrospectively compared between patients with SLNB (n=56) or ILND (n=56). PT2 tumors (59% vs. 11%; p<0.001) and complete vulvectomy (39% vs. 4%; p < 0.001) occured more often in the ILND than the SLNB group with no difference in lymph node recurrence rate. Multivariate survival analysis considering the year of primary diagnosis, tumor stage and surgery revealed no significant effect of treatment on DFS (p=0.062) or OS (p=0.924). SLNB seems to be a safe treatment for women with pT1/T2 nodal-negative vulvar cancer with no difference in DFS or OS compared to ILND. Those results confirm the results of the GROINSS-V Study and other literature with the longest follow-up data reported within a real-life collective. Impact statementSLNB has been shown to reduce postoperative morbidity in women with vulvar cancer, however, data on long-term outcome of SLNB in vulvar cancer is rare. The aim of this study was to evaluate the outcome of patients with nodal-negative vulvar cancer that had undergone either SLNB or ILND in a clinical collective. Patients in the ILND group presented with more pT2 tumors (59% vs. 11%; p< 0.001) and followed by complete vulvectomy (39% vs. 4%; p <0.001). The lymph node recurrence rate was not significantly different between both groups (p=0.57). A multivariate survival analysis accounting for year of primary diagnosis, tumor stage and type of surgery revealed no significant effect of treatment on DFS or OS. SLNB seems to be a safe treatment for women with T1/T2 nodal-negative vulvar cancer, as we observed no difference in DFS or OS compared to patients with ILND. However, because of the observed bias between the two groups, results have to be interpreted carefully and need to be confirmed in larger prospective trials. Nevertheless, the results represent further data regarding the oncological safety of SNB supporting current literature and strongly underlie its value in the described setting with the longest follow-up, to date, reported.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparison of Outcome after Sentinel Lymph Node Biopsy or Inguinal Lymph Node Dissection in Patients with Nodal Negative Squamous Vulvar Cancer

Ebner¹,

Antje²,

Schramm³

et al. 2017

Glob Surg

View full text Add to dashboard Cite

show abstract

“…More often lymphoedema is a result of treatment, either surgical excision of draining lymphnodes and / or radiotherapy [3]. Lymphoedema of the vulva can be a postoperative complication after vulvectomy and inguino femoral lymphadenectomy [4]. Vulval lymphoedema can be a rare extra-intestinal manifestation of Crohn's disease [5,6] but the ulcer in such cases shows epitheloid and giant cell granulomas.…”

Section: Discussionmentioning

confidence: 99%

Lymphoedema Vulva

Patra¹,

Das²,

Ramadasan³

2007

Medical Journal Armed Forces India

View full text Add to dashboard Cite

“…And vulva surgery presented total of 20% complication [18]. The efficiency of the surgical method of care is satisfactory for the located stage, with a total recidivating of 1-10% [7].…”

Section: Epidemiological Aspectmentioning

confidence: 99%

Invasive Cancer of the Vulva: Clinical and Therapeutic Aspects in the Gynecology and Obstetrics Service at Donka Hospital, Guinea- Conakry

Mk¹,

Ld²,

Diarra³

et al. 2017

Gynecol Obstet

View full text Add to dashboard Cite

Results Epidemiological aspectThe frequency: The vulva cancer is rare with 12 cases among 1234 about 1%. Medium ageThe medium age during the diagnosis was 54 years with extreme of 22 and 84 years. 75% of women were olded than 55 years and menopause. The socio-economic levelThe women have low socio-economic level married women 5% housewife 67% and multiparous 75%. Clinical aspectsParity: 75% of vulva cancer was found in multiparous with a polygamy sexual regimen (Figure 1 We noted 1% of vulva cancer among the 1234 cases of Gynecological cancers diagnosed in the service. Two-third of the patients were elder than 55 years and the multiparous with 75%.The prurition and the tumefaction were the principal motive of consultation among 41.66 %.The tumor had epithelial origin in the clinical stage III in 50% of cases according to FIGO (2009). 3.6% of vulvectomy associated with lymphadenectomy in two-third and one case of radiotherapy.The cancers cases recorded were invasive epithelium type in old age women. These were intended to allow precocious diagnose and adequate taking care of the disease.

show abstract

Postoperative complications after vulvectomy and inguinofemoral lymphadenectomy using separate groin incisions

Cited by 250 publications

References 14 publications

Comparison of Outcome after Sentinel Lymph Node Biopsy or Inguinal Lymph Node Dissection in Patients with Nodal Negative Squamous Vulvar Cancer

Comparison of Outcome after Sentinel Lymph Node Biopsy or Inguinal Lymph Node Dissection in Patients with Nodal Negative Squamous Vulvar Cancer

Lymphoedema Vulva

Invasive Cancer of the Vulva: Clinical and Therapeutic Aspects in the Gynecology and Obstetrics Service at Donka Hospital, Guinea- Conakry

Contact Info

Product

Resources

About