Postoperative Analgesia by Intravenous Clonidine

Bernard, Jean-Marc; Hommeril, Jean-Luc; Passuti, N; Pinaud, M.

doi:10.1097/00000542-199110000-00006

Cited by 158 publications

(55 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…1-3, which are individual Forest plots). 18,20,21,24,26,29,33,37,38,43 At 2 h after surgery, the median of all average cumulative morphine equivalents in control subjects was 12.2 mg (range, 7.0 -17.3); clonidine did not significantly decrease this amount. 33,37 At 12 h, the median of the average cumulative morphine-equivalents in controls was 30.1 mg (range, 10.8 -36.0), and clonidine showed a significant morphine-sparing effect (WMD Ϫ9.8 mg).…”

Section: Postoperative Consumption Of Morphine Equivalentsmentioning

confidence: 89%

Effect of Perioperative Systemic α2 Agonists on Postoperative Morphine Consumption and Pain Intensity

et al. 2012

View full text Add to dashboard Cite

Background: Systemic ␣2 agonists are believed to reduce pain and opioid requirements after surgery, thus decreasing the incidence of opioid-related adverse effects, including hyperalgesia. Methods: The authors searched for randomized placebocontrolled trials testing systemic ␣2 agonists administrated in surgical patients and reporting on postoperative cumulative opioid consumption and/or pain intensity. Meta-analyses were performed when data from 5 or more trials and/or 100 or more patients could be combined. Results: Thirty studies (1,792 patients, 933 received clonidine or dexmedetomidine) were included. There was evidence of postoperative morphine-sparing at 24 h; the

show abstract

Section: Postoperative Consumption Of Morphine Equivalentsmentioning

confidence: 89%

Effect of Perioperative Systemic α2 Agonists on Postoperative Morphine Consumption and Pain Intensity

et al. 2012

View full text Add to dashboard Cite

show abstract

“…Bernard and co-workers reported the analgesic effects of an intravenous infusion of clonidine after major spinal surgery [158]. They administered either clonidine 5 mg.kg À1 during the first hour followed by 0.3 mg.kg À1 .h À1 for 11 h or placebo.…”

Section: Analgesiamentioning

confidence: 99%

Alpha‐2 and imidazoline receptor agonistsTheir pharmacology and therapeutic role

Khan¹,

Ferguson²,

Jones³

1999

Anaesthesia

598

423

View full text Add to dashboard Cite

SummaryClonidine has proved to be a clinically useful adjunct in clinical anaesthetic practice as well as in chronic pain therapy because it has both anaesthetic and analgesic-sparing activity. The more selective alpha-2 adrenoceptor agonists, dexmedetomidine and mivazerol, may also have a role in providing haemodynamic stability in patients who are at risk of peri-operative ischaemia. The side-effects of hypotension and bradycardia have limited the routine use of alpha-2 adrenoceptor agonists. Investigations into the molecular pharmacology of alpha-2 adrenoceptors have elucidated their role in the control of wakefulness, blood pressure and antinociception. We discuss the pharmacology of alpha-2 adrenoceptors and their therapeutic role in this review.

show abstract

“…Clonidine administered intrathecally or epidurally produces analgesia, i-4 Clonidine administered orally has been reported to provide perioperative sedation, 5,6 to reduce anaesthetic requirements 7,8 and to produce postoperative analgesia, 6 and intravenous clonidine can produce postoperative analgesia. 9 More recently, there have been several studies in regard to clonidine added to local anaesthetics. ~~ Nishikawa et al io reported that the addition of clonidine to lidocaine for epidural anaesthesia tended to increase the plasma lidocaine concentrations.…”

Section: Clonidine Does Not Affect Lidocaine Seizure Threshold In Ratsmentioning

confidence: 99%

Clonidine does not affect lidocaine seizure threshold in rats

1993

View full text Add to dashboard Cite

We investigated the effect of clonidine on intravenous (iv) lidocaine-induced haemodynamic changes and convulsions in awake rats. Wistar rats (200-250 g) were divided into three groups of eight and were pretreated with iv clonidine or normal saline 15 rain before lidocaine infusion. Group 1 received normal saline; Group 2, and Group 3, (Group 1:10.5 + 0.3, Group 2:10.8 5: 0.3, respectively (groupe I: 41,8 5: 2,2; groupe 2:43,8 • 2,3; groupe 3:42,3 + 2 rag" kg -t) (groupe 1:10,5 -t-0,3; groupe 2:10,8 4-0,3; groupe 3:10,6 + 0,3 ttg" ml-J) ni les concentrations plasmatiques de lidoca?ne ddclenchant les convulsions

show abstract

Postoperative Analgesia by Intravenous Clonidine

Cited by 158 publications

References 0 publications

Effect of Perioperative Systemic α2 Agonists on Postoperative Morphine Consumption and Pain Intensity

Effect of Perioperative Systemic α2 Agonists on Postoperative Morphine Consumption and Pain Intensity

Alpha‐2 and imidazoline receptor agonistsTheir pharmacology and therapeutic role

Clonidine does not affect lidocaine seizure threshold in rats

Contact Info

Product

Resources

About