J. Neurosci. Res. volume 86, issue 6, P1267-1276 2008 DOI: 10.1002/jnr.21584 View full text
Lucian Soane, Zachary T. Siegel, Rosemary A. Schuh, Gary Fiskum

Abstract: AbstractAlthough it has been long recognized that the relative balance of pro-and antiapoptotic Bcl-2 proteins is critical in determining the susceptibility to apoptotic death, only a few studies have examined the level of these proteins specifically at mitochondria during postnatal brain development. In this study, we examined the age-dependent regulation of Bcl-2 family proteins using rat brain mitochondria isolated at various postnatal ages and from the adult. The results indicate that a general downregula…

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