Postmenopausal bleeding due to cervical involvement with Wegener's granulomatosis

Maina, W. C.; Crocker, Simon G.; Scott, Dgi; Ali, Ahsan

doi:10.1080/01443610802633940

Cited by 8 publications

(12 citation statements)

References 9 publications

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“…To our knowledge, only 6 cases have been previously reported, [3][4][5][6][7][8] and the occurrence of cervical abnormalities as the first manifestation has been described in only a single case. 4 In a cohort of 158 patients with diagnosis of GPA, biopsy-proven granulomatosis of the cervix was reported in less than 1% of patients.…”

Section: Involvement Of Uterine Cervix As the First Manifestation Of mentioning

confidence: 69%

Involvement of Uterine Cervix as the First Manifestation of Granulomatosis With Polyangiitis

Caron

Michaud

Gariépy

et al. 2014

Journal of Clinical Rheumatology

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Section: Involvement Of Uterine Cervix As the First Manifestation Of mentioning

confidence: 69%

Involvement of Uterine Cervix as the First Manifestation of Granulomatosis With Polyangiitis

Caron

Michaud

Gariépy

et al. 2014

Journal of Clinical Rheumatology

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“…Once studies with patients with MPA or EGPA (5) were removed, a total of 17 studies fulfilled all inclusion criteria and were selected for full-text evaluation and systematic review [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. After reviewing the 17 articles, 18 patients were identified as GPA with gynecological involvement (two patients reported by Stone et al) [12].…”

Section: Main Findingsmentioning

confidence: 99%

Granulomatosis with Polyangiitis-Mimicking Advanced Gynecological Cancer: A Case Report and Systematic Review of the Literature

Pereira

Magrina

Magtibay

et al. 2022

JPM

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(1) Background: Granulomatosis with polyangiitis (GPA) is a necrotizing vasculitis that mimics gynecologic cancer. In GPA patients, the genitourinary system is affected in <1%. The objective of the study was to provide a systematic review of the literature of GPA patients with gynecological involvement. (2) Methods: PubMed and Embase were searched from inception to July 2021 for GPA patients with gynecological involvement Medical Subject Headings (MeSH) and free-text terms. Exclusion criteria were other language, review articles, pregnancy, fertility, or male patients. Data were extracted on clinical evolution, symptoms, examinations findings, diagnosis delay, treatment, outcome, patient status, and follow-up. (3) Results: Seventeen studies included data from patients with GPA and primary or relapsed gynecological involvement. 68% of the authors of this review thought the patient had cancer. The main gynecological symptom is bleeding, but exclusive gynecologic symptomatology is rare (ENT: 63%, lungs: 44%, kidneys-urinary tract: 53%). GPA could affect all areas of the genital tract, but the most frequent location is the uterine cervix. Medical treatment for GPA is effective. (4) Conclusions: GPA of the female genital tract must be considered when biopsies of an ulcerated malignant-appearing cervical or vaginal mass are negative for malignancy even when they are unspecific. Rheumatology consultation is indicated.

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“…Genital tract involvement in GPA while unusual has been reported in the literature, [1][2][3][4][5][6] with most published cases showing varying responses to cyclophosphamide. A case reported by Bastone et al demonstrates near resolution of disease at 20 months post commencement of rituximab therapy.…”

mentioning

confidence: 99%

Granulomatosis with polyangiitis complicated by genital involvement: sustained response to rituximab

Paxton

Crespigny

Nicholls

2021

Internal Medicine Journal

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Postmenopausal bleeding due to cervical involvement with Wegener's granulomatosis

Cited by 8 publications

References 9 publications

Involvement of Uterine Cervix as the First Manifestation of Granulomatosis With Polyangiitis

Involvement of Uterine Cervix as the First Manifestation of Granulomatosis With Polyangiitis

Granulomatosis with Polyangiitis-Mimicking Advanced Gynecological Cancer: A Case Report and Systematic Review of the Literature

Granulomatosis with polyangiitis complicated by genital involvement: sustained response to rituximab

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