Postmastectomy Low-Grade Angiosarcoma

Drachman, David A.; Rosen, Larry; Sharaf, Doaa M.; Weissmann, Arthur

doi:10.1097/00000372-198806000-00010

Cited by 12 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Discussionmentioning

confidence: 94%

“…Clinically, the average time between radical mastectomy and angiosarcoma progression is reported to 12.5 years, displaying various features, such as red-blue firm nodules, plaques, blood blisters or ulcer formation, usually in the background of more than 10-years lymphedema [1,2], unlike the present case. In addition, extremely rare long-term survivors with Stewart-Treves syndrome are reported to have early amputation of the affected extremity [2]. Our case actually showed neither local invasion nor metastases within the post-operative 7 years with additional treatment of immunotherapy and adjuvant chemo-radiotherapy, but was also alive and well at 5 years after the final chemotherapy, manifesting as overtly benign clinical behavior.…”

Section: Discussionmentioning

confidence: 94%

“…Enzinger and Weiss have classified them as follows: (a) cutaneous angiosarcoma associated with lymphedema; (b) cutaneous angiosarcoma unassociated with lymphedema; (c) angiosarcoma of the breast; and (d) angiosarcoma of deep soft tissue [1]. Intriguingly, about 90% of all (a) angioosarcomas associated with chronic lymphedema occur after mastectomy for breast cancer [1,2]. Actually, Stewart and Treves first reported the development of angiosarcoma arising on longstanding lymphedematous extremities, due to axillary lymph nodes dissection following a radical mastectomy, named as the so-called Stewart-Treves syndrome, in 1948 [3].…”

Section: Introductionmentioning

confidence: 99%

“…Actually, Stewart and Treves first reported the development of angiosarcoma arising on longstanding lymphedematous extremities, due to axillary lymph nodes dissection following a radical mastectomy, named as the so-called Stewart-Treves syndrome, in 1948 [3]. Clinically, this disease is characterized by red to blue and firm nodules and/or plaques on the affected extremities [2,3]. To date, more than 400 cases of Stewart-Treves syndrome have been described in the literature, and the patients have a very poor prognosis, complicated with recurrence, distant metastases, and very early death within 2 years [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…To date, more than 400 cases of Stewart-Treves syndrome have been described in the literature, and the patients have a very poor prognosis, complicated with recurrence, distant metastases, and very early death within 2 years [3,4]. It is also noteworthy that the prevalence is estimated at about 0.45% in patients with Stewart-Treves syndrome who survive longer than post-operative 5 years [4], and in fact, that very few long-term survivors have been recognized [1,2]. …”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Post-mastectomy benign lymphangioendothelioma of the skin following chronic lymphedema for breast carcinoma: a teaching case mimicking low-grade angiosarcoma and masquerading as Stewart-Treves syndrome

Yamada

Miwa

et al. 2014

Diagn Pathol

View full text Add to dashboard Cite

Benign lymphangioendothelioma (BL) represents a very rare lymphatic vascular proliferation. Our aim is to be aware that owing to its characteristic features, pathologists can easily misinterpret it as cutaneous low-grade angiosarcoma when examining only small specimens. In the present case, multiple small and yellowish to reddish soft nodules were noticed in the edematous left arm of a 54-year-old Japanese female 4 years after the radical mastectomy with axillary lymph nodes dissection and following radiotherapy to the chest for the left breast carcinoma. The biopsy specimen showed an ill-defined lesion composed of a proliferation of irregular and sometimes anastomosing vascular structures in the dermis, lined by endothelial cells having mildly hyperchromatic and pleomorphic nuclei, but no mitotic figures. As the lesion grew within deeper dermis, these proliferating vessels dissected dermal collagenous bands, occasionally arranged in low-papillary projections and/or characteristic hobnail cytomorphology. We first interpreted it as low-grade angiosarcoma following chronic lymphedema due to the operation, i.e., the so-called Stewart-Treves syndrome. Although additional treatments were performed for 7 years, she had neither local invasion nor metastases of these tumors, respectively, and was alive and well. Retrospective immunohistochemical findings demonstrated that these mildly atypical endothelial cells were strongly positive for lymphatic vessel endothelial hyaluronan receptor (LYVE)-1 as well, and MIB-1 labeling index was less than 1%. Therefore, we finally made a diagnosis of BL of the skin. MIB-1 labeling index might be useful and adjunctive aids for reaching the correct diagnosis of cutaneous BL, especially in case of small or inadequate specimens.Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/13000_2014_197

show abstract

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Post-mastectomy benign lymphangioendothelioma of the skin following chronic lymphedema for breast carcinoma: a teaching case mimicking low-grade angiosarcoma and masquerading as Stewart-Treves syndrome

Yamada

Miwa

et al. 2014

Diagn Pathol

View full text Add to dashboard Cite

show abstract

Dermoscopic-Histopathologic Correlation of Cutaneous Lymphangioma Circumscriptum

Scope

Amini

Kim³

et al. 2008

Arch Dermatol

View full text Add to dashboard Cite

The coexistence of lymphangiosarcoma and kaposi's sarcoma in a renal transplant recipient

Studniberg

Rivers

Cooke

et al. 1991

Cancer

View full text Add to dashboard Cite

A case of coexisting lymphangiosarcoma and Kaposi's sarcoma that occurred in a female renal transplant recipient is presented. Both sarcomas were localized to the skin and were slowly progressive over several years. The coexistence of these two sarcomas may indicate that they arose from a common precursor endothelial cell and that systemic immune suppression may be important in the pathogenesis of both these malignancies. Cancer 68:2330–2335, 1991.

show abstract

Postmastectomy Low-Grade Angiosarcoma

Cited by 12 publications

References 0 publications

Post-mastectomy benign lymphangioendothelioma of the skin following chronic lymphedema for breast carcinoma: a teaching case mimicking low-grade angiosarcoma and masquerading as Stewart-Treves syndrome

Post-mastectomy benign lymphangioendothelioma of the skin following chronic lymphedema for breast carcinoma: a teaching case mimicking low-grade angiosarcoma and masquerading as Stewart-Treves syndrome

Dermoscopic-Histopathologic Correlation of Cutaneous Lymphangioma Circumscriptum

The coexistence of lymphangiosarcoma and kaposi's sarcoma in a renal transplant recipient

Contact Info

Product

Resources

About