Posterior parietal cortex control of reach‐to‐grasp movements in humans

Chapman, Heidi; Gavrilescu, Maria; Wang, Hong; Kean, Michael; Egan, Gary F.; Castiello, Umberto

doi:10.1046/j.1460-9568.2002.02021.x

Cited by 48 publications

(23 citation statements)

References 23 publications

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“…The activations were greater during the reaching task compared to arm extension. A similar fronto-parietal network for reaching has been observed in other functional neuroimaging and electrophysiological studies [2,5,17]. …”

Section: Discussionsupporting

confidence: 81%

Phantom haptic device upgrade for use in fMRI

Hribar

Koritnik

Munih

2009

Med Biol Eng Comput

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This paper presents an upgrade of a Phantom Premium 1.5 haptic device for use within a functional magnetic resonance imaging (fMRI) environment. A special mechanical extension that allows the haptic device to operate at a safe distance from the high-density magnetic field of an fMRI scanner has been developed. Extended haptic system was subjected to a series of tests to confirm electromagnetic compatibility with the fMRI scanner, for which key results are presented. With this fMRI compatible haptic platform a human brain activation during controlled upper limb movements can be studied. A simple virtual environment reaching task was programmed to study brain motor control functions. At the end preliminary results of an ongoing neurophysiological study are presented.

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Section: Discussionsupporting

confidence: 81%

Phantom haptic device upgrade for use in fMRI

Hribar

Koritnik

Munih

2009

Med Biol Eng Comput

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“…Another possibility is that hIPS corresponds to human LIP [75], which may relay inputs from macaque V3A to AIP [76]. Activation in the left PO has been previously reported for grasping [77] and pointing [78]–[80]. This region in humans may be homologous with a monkey area in the anterior bank of PO (V6A), in which a sub-population of neurons selectively responds when the monkey attends to, reaches towards, or grasps an object [81].…”

Section: Discussionmentioning

confidence: 88%

FMRI Reveals a Dissociation between Grasping and Perceiving the Size of Real 3D Objects

2007

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BackgroundAlmost 15 years after its formulation, evidence for the neuro-functional dissociation between a dorsal action stream and a ventral perception stream in the human cerebral cortex is still based largely on neuropsychological case studies. To date, there is no unequivocal evidence for separate visual computations of object features for performance of goal-directed actions versus perceptual tasks in the neurologically intact human brain. We used functional magnetic resonance imaging to test explicitly whether or not brain areas mediating size computation for grasping are distinct from those mediating size computation for perception.Methodology/Principal FindingsSubjects were presented with the same real graspable 3D objects and were required to perform a number of different tasks: grasping, reaching, size discrimination, pattern discrimination or passive viewing. As in prior studies, the anterior intraparietal area (AIP) in the dorsal stream was more active during grasping, when object size was relevant for planning the grasp, than during reaching, when object properties were irrelevant for movement planning (grasping>reaching). Activity in AIP showed no modulation, however, when size was computed in the context of a purely perceptual task (size = pattern discrimination). Conversely, the lateral occipital (LO) cortex in the ventral stream was modulated when size was computed for perception (size>pattern discrimination) but not for action (grasping = reaching).Conclusions/SignificanceWhile areas in both the dorsal and ventral streams responded to the simple presentation of 3D objects (passive viewing), these areas were differentially activated depending on whether the task was grasping or perceptual discrimination, respectively. The demonstration of dual coding of an object for the purposes of action on the one hand and perception on the other in the same healthy brains offers a substantial contribution to the current debate about the nature of the neural coding that takes place in the dorsal and ventral streams.

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“…For example, reaching-related neurons in macaque area V6A appear to be sensitive not only to reach direction (Fattori et al, 2004), but also to target orientation (Galletti et al, 1999; Fattori et al, 2009), target shape (Fattori et al, 2012), and grasp configuration (Fattori et al, 2010). Similarly, functional magnetic resonance imaging (fMRI) investigations in humans reported grasping-related parieto-occipital and dorsal premotor cortex activations (Chapman et al, 2002; Begliomini et al, 2007a,b, 2008; Gallivan et al, 2011), which might be considered the possible human homolog for monkey areas V6A and F2, respectively. Moreover, a recent neuroimaging study, based on the effective parieto-frontal connectivity, argues against the existence of dedicated circuits for reaching and grasping (Grol et al, 2007).…”

Section: Introductionmentioning

confidence: 95%

An investigation of the neural circuits underlying reaching and reach-to-grasp movements: from planning to execution

Begliomini

Sanctis

Marangon

et al. 2014

Front. Hum. Neurosci.

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Experimental evidence suggests the existence of a sophisticated brain circuit specifically dedicated to reach-to-grasp planning and execution, both in human and non-human primates (Castiello, 2005). Studies accomplished by means of neuroimaging techniques suggest the hypothesis of a dichotomy between a “reach-to-grasp” circuit, involving the anterior intraparietal area, the dorsal and ventral premotor cortices (PMd and PMv – Castiello and Begliomini, 2008; Filimon, 2010) and a “reaching” circuit involving the medial intraparietal area and the superior parieto-occipital cortex (Culham et al., 2006). However, the time course characterizing the involvement of these regions during the planning and execution of these two types of movements has yet to be delineated. A functional magnetic resonance imaging study has been conducted, including reach-to-grasp and reaching only movements, performed toward either a small or a large stimulus, and Finite Impulse Response model (Henson, 2003) was adopted to monitor activation patterns from stimulus onset for a time window of 10 s duration. Data analysis focused on brain regions belonging either to the reaching or to the grasping network, as suggested by Castiello and Begliomini (2008). Results suggest that reaching and grasping movements planning and execution might share a common brain network, providing further confirmation to the idea that the neural underpinnings of reaching and grasping may overlap in both spatial and temporal terms (Verhagen et al., 2013). But, although responsive for both actions, they show a significant predominance for either one of the two actions and such a preference is evident on a temporal scale.

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Posterior parietal cortex control of reach‐to‐grasp movements in humans

Cited by 48 publications

References 23 publications

Phantom haptic device upgrade for use in fMRI

Phantom haptic device upgrade for use in fMRI

FMRI Reveals a Dissociation between Grasping and Perceiving the Size of Real 3D Objects

An investigation of the neural circuits underlying reaching and reach-to-grasp movements: from planning to execution

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