Postconditioning of the Lower Limb—Protection Against the Reperfusion Syndrome

Gyurkovics, Endre; Arányi, Péter; Stangl, Rita; Ónody, Péter; Ferreira, G Cordeiro; Lotz, Gábor; Kempler, Péter; Szíjártó, Attila

doi:10.1016/j.jss.2009.10.014

Cited by 34 publications

(35 citation statements)

References 25 publications

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“…The histological analyses of the I/R group showed areas of collapsed alveoli and thickening of alveolar walls, whereas in the IPostC group the alterations were minimal, corroborating the protective effect of IPostC in the present study 24 .…”

supporting

confidence: 89%

“…Studies show the efficiency of IPostC as cardioprotector in cardiac revascularization surgery, with smaller muscle injury; this concept was first described in 2003 by Zhao et al 23 , which demonstrates its higher efficiency in relation to preconditioning, in myocardial revascularization surgery. Recently, this concept was expanded by experimental lower-limb I/R models, by infrarenal aorta clamping, simulating abdominal aorta surgery 24 . Gyurkovics et al 24 were the first to describe this study, in which it is demonstrated the efficiency of IPostC in minimazing systemic damage and multipleorgan complications resulting from lower-limb I/R.…”

mentioning

confidence: 99%

“…Recently, this concept was expanded by experimental lower-limb I/R models, by infrarenal aorta clamping, simulating abdominal aorta surgery 24 . Gyurkovics et al 24 were the first to describe this study, in which it is demonstrated the efficiency of IPostC in minimazing systemic damage and multipleorgan complications resulting from lower-limb I/R. IPostC was efficient in the reduction of lung and kidney remote injury, tumor necrosis factor and ROS…”

mentioning

confidence: 99%

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The influence of allopurinol and post-conditioning on lung injuries induced by lower-limb ischemia and reperfusion in Wistar rats

Akahane

Gomes²,

Paludo³

et al. 2017

Acta Cir. Bras.

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1 AbstractPurpose: To analyze the effects of allopurinol and of post-conditioning on lung injuries induced by lower-limb ischemia and reperfusion. Methods: Thirty rats were used. They were divided in 5 groups: (1) group A: abdominal aortic dissection only, (2) group B: ischemia and reperfusion, (3) group C: administered allopurinol (100mg/Kg) a few hours before procedure, (4) group D: post-conditioned and (5) group E: administered allopurinol and post-conditioned. With the exception of group A, all groups were submitted to infrarenal aortic ischemia for 2 hours, and reperfusion for 72 hours. After euthanasia, lungs were removed for histological analysis. They were graded under two scores: pulmonary injury (neutrophil infiltration, interstitial edema, vascular congestion, and destruction of lung architecture) and lymphocytic score (neutrophil infiltration, lymphoid aggregate and secondary follicle). Results: On the pulmonary injury score, the degree of injury was smaller than in groups D and E, when compared to group B, p<0.05. Group C did not obtain the same result (p>0,05). On the lymphocytic score, there was no statistic difference among groups, p>0.05. Conclusion: Both post-conditioning and the combination of allopurinol and post-conditioning were effective in remote lung protection induced by lower-limbs I/R. When used in isolation, allopurinol showed no protective effect.

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confidence: 89%

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confidence: 99%

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confidence: 99%

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The influence of allopurinol and post-conditioning on lung injuries induced by lower-limb ischemia and reperfusion in Wistar rats

Akahane

Gomes²,

Paludo³

et al. 2017

Acta Cir. Bras.

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“…A most recent study shows that postconditioning caused a significant reduction in systemic inflammatory response evidenced as reduced production of tumor necrosis factor-a (TNF-a) and reactive oxygen species [8]. On the other hand, deficiency of heme oxygenase-1 impairs renal hemodynamics and exaggerates systemic inflammatory responses to renal ischemia [9].…”

Section: Introductionmentioning

confidence: 99%

Ischemic Postconditioning Attenuates Lung Reperfusion Injury and Reduces Systemic Proinflammatory Cytokine Release Via Heme Oxygenase 1

Xu¹,

Gao²,

Xu³

et al. 2011

Journal of Surgical Research

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“…The rapid release of oxygen free radicals and inflammatory mediatorsespecially polymorphonuclear leukocytes-induce both systemic and local damage with reperfusion [1,2] . These products may lead to complications due to systemic inflammatory response such as multiorgan failure and even death [3] . The lungs, heart, and kidneys are distant organs that are especially damaged after ischemia and reperfusion.…”

Section: Introductionmentioning

confidence: 99%

Böbrekte İskemi-Reperfüzyon Hasarında Ticagrelor’un Etkisi: Pleiotropik Etki Geçerli Bir Faktör mü?

Bağcıoğlu¹,

Kocaaslan²,

Uslu³

et al. 2017

Kafkas Univ Vet Fak Derg

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Citation of This ArticleBağcıoğlu M, Kocaaslan R, Uslu M, Fındık Güvendi G: The effect of ticagrelor on ischemia-reperfusion injury of kidney: Is the pleiotropic effect a valid factor? Kafkas Univ Vet Fak Derg, 23 (6): 917-924, 2017. DOI: 10.9775/kvfd.2017 AbstractThe goal of this study was to determine the protective effect of ticagrelor against ischemia-reperfusion injury in the kidney of rats via histological examination, biochemical parameters, and immunohistochemical analysis. Thirty male rats were randomized into five groups. The animals received ticagrelor 5 mg/kg, 10 mg/kg and 20 mg/kg or normal saline 0.1 mL/kg (control) orally before the procedure. The shame group only had laparatomy. An ischemia-reperfusion injury was done by clamping the renal hilus. There was less malondealdehyde assay (MDA) in ticagrelor groups than the control group, and this decrease was statistically significant (P=0.001 in all ticagrelor received groups). The glutathione peroxidase (GPx) and glutathione reductase (GR) were elevated in ticagrelor groups at all doses. Similar findings were observed in all treatment groups. The 5 mg ticagrelor treated group had no changes in glomerules and tubules relative to the control group via histology. Dilated tubular structures were similar to the sham group-both at 10 and 20 mg ticagrelor. Caspas-3 and NF-KB activity was similar in ticagrelor treated groups to sham group. Our study showed that ticagrelor is an effective agent to protect kidney from renal ischemia-reperfusion injury. Ticagrelor may protect the tissues by reducing the concentration of reactive oxygen species and inducing the antioxidant system-especially with the pleiotropic effect. Keywords: Kidney, Ischemia, Reperfusion, Injury, TicagrelorBöbrekte İskemi-Reperfüzyon Hasarında Ticagrelor'un Etkisi: Pleiotropik Etki Geçerli Bir Faktör mü? ÖzetBu çalışmada, ticagrelor'un ratların böbreğinde oluşturulan iskemi-reperfüzyon hasarına karşı koruyucu etkisinin histolojik, biyokimyasal ve immünohistokimyasal yöntemler kullanılarak tanımlanması amaçlanmıştır. Bu amaçla, 30 erkek rat rastgele olarak 5 gruba ayırılmıştır. Bu hayvanlara, yapılacak işlemlerden önce ticagrelor 5 mg/kg, 10 mg/kg ve 20 mg/kg dozlarında, kontrol grubuna da 0.1 mL/kg serum fizyolojik oral olarak verilmiştir. Sham grubunda ise sadece laparatomi yapılmıştır. İskemi-reperfüzyon hasarı renal hilusun klemplenmesi yoluyla yapılmıştır. Ticagrelor verilen gruplarda saptanan malondialdehit (MDA) düzeyinin kontrol grubundan daha az olduğu ve bu düşüklüğün istatistiksel olarak anlamlı olduğu tespit edildi (tüm ticagrelor grupları için P=0.001). Glutatyonperoksidaz (GPx) ve glutatyonredüktaz (GR) düzeyleride ticagrelor verilen tüm gruplarda artmış olarak bulundu. Histopatolojik incelemelerde, tedavi verilen tüm gruplarda benzer sonuçlar gözlendi. Ancak 5 mg ticagrelor verilen grupta glomerul ve tübül yapısında kontrol grubu arasında fark olmadığı belirlendi. 10 ve 20 mg ticagrelor verilen gruplarda, sham grubuna benzer özellikte dilate tübüler yapılar olduğu gözlendi. C...

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Postconditioning of the Lower Limb—Protection Against the Reperfusion Syndrome

Cited by 34 publications

References 25 publications

The influence of allopurinol and post-conditioning on lung injuries induced by lower-limb ischemia and reperfusion in Wistar rats

The influence of allopurinol and post-conditioning on lung injuries induced by lower-limb ischemia and reperfusion in Wistar rats

Ischemic Postconditioning Attenuates Lung Reperfusion Injury and Reduces Systemic Proinflammatory Cytokine Release Via Heme Oxygenase 1

Böbrekte İskemi-Reperfüzyon Hasarında Ticagrelor’un Etkisi: Pleiotropik Etki Geçerli Bir Faktör mü?

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