Manipulation in modern society is one of the fundamental mechanisms of confrontation between countries. Through consideration of this issue on historical facts, it can be concluded that this article reveals the technologies of political manipulation in the post-truth era (on the example of the confrontation between the United States and the Russian Federation) through the study of theoretical and methodological aspects and consideration of post-truth as a tool for constructing and modifying political reality, leaving to manipulation through the post-truth tool. The object in this study is post-truth as a form of influence on the consciousness of citizens and its formation in modern political discourse, while the subject: Technologies and methods of political manipulation of consciousness in modern discourse (the era of post-truth). In study, the author solves following tasks as to define the basic concepts that designate the post-truth era and distinguish it from others, identify the main methods, technologies of political manipulation in the era of post-truth, identify the features of political interaction in the era of post-truth, determine the degree of development of this phenomenon in world politics, using the example of the information confrontation between the Russian Federation and the United States of America, and also, determine the degree of effectiveness of the influence of post-truth technologies on modern political processes.