Post-Transplant HLA class II Antibodies and High Soluble CD30 Levels are Independently Associated with Poor Kidney Graft Survival

Langan, L.; Park, L.P.; Hughes, Tracey; Irish, Ashley; Luxton, Grant; Witt, Campbell S.; Christiansen, Frank

doi:10.1111/j.1600-6143.2006.01691.x

Cited by 64 publications

(47 citation statements)

References 35 publications

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“…10 -12 High post-transplant sCD30 levels are a risk factor for acute rejection and decreased graft survival in renal transplantation. 13,14 In addition, in lung transplantation, a similar observation was made: high posttransplant sCD30 concentrations correlated well with the development of BOS. 15,16 In those studies a cyclosporine-based immunosuppressive regimen was used.…”

mentioning

confidence: 62%

“…14,17 The exact mechanism of sCD30 suppression is unknown but clinical studies have shown fewer acute rejections and a trend toward a lower incidence of BOS in a tacrolimus-based regimen compared with cyclosporine, and fewer malignancies were observed in mycophenolate mofetil when compared with azathioprine. 18,19 During the development of BOS, Fields and colleagues reported a 10-fold rise in sCD30 levels, but not in matched non-BOS patients, and therefore concluded that sCD30 could be used as a biomarker for the development of BOS.…”

Section: Discussionmentioning

confidence: 99%

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Soluble CD30 Measured After Lung Transplantation Does Not Predict Bronchiolitis Obliterans Syndrome in a Tacrolimus/Mycophenolate Mofetil–based Immunosuppressive Regimen

Erp

Otten

Paantjens

et al. 2008

The Journal of Heart and Lung Transplantation

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mentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Soluble CD30 Measured After Lung Transplantation Does Not Predict Bronchiolitis Obliterans Syndrome in a Tacrolimus/Mycophenolate Mofetil–based Immunosuppressive Regimen

Erp

Otten

Paantjens

et al. 2008

The Journal of Heart and Lung Transplantation

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“…Preformed anti-donor class II antibodies increase the risk of transplant failure [1][2][3][4][5][6][7][8][9] and the post-transplant development of anti-class II antibodies is associated with a higher incidence of acute and chronic rejection [10][11][12][13][14][15][16][17][18][19] Current class II matching strategies for kidney transplantation consider only the HLA-DR antigens controlled by the DRB1 locus but mismatching for HLA-DQ and HLA-DP may also lead to lower graft survival rates [20][21][22][23][24][25]. Newer serum screening methods such as ELISA, Flow Cytometry and Luminex have greatly enhanced the detection of anti-HLA-DQ and HLA-DP antibodies and their association with transplant rejection [2,7,[26][27][28][29].…”

Section: Introductionmentioning

confidence: 99%

Retransplant candidates have donor-specific antibodies that react with structurally defined HLA-DR,DQ,DP epitopes

Duquesnoy

Awadalla

Lomago

et al. 2008

Transplant Immunology

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This report describes a detailed analysis how donor-specific HLA class II epitope mismatching affects antibody reactivity patterns in 75 solid organ transplant recipients with an in situ allograft and who were considered for retransplantation. Sera were tested for antibodies in a sensitive antigenbinding assay (Luminex) with single class II alleles. Their reactivity was analyzed with HLAMatchmaker, a structural matching algorithm that considers so-called eplets to define epitopes recognized by antibodies. Only 24% of the patients showed donor-specific anti-DRB1 antibodies and there was a significant correlation with a low number of mismatched DRB1 eplets. This low detection rate of anti-DRB1 antibodies may also be due to allograft absorption. In contrast, antibodies to DRB3/4/5 mismatches were more common. Especially, 83% of the DRB4 (DR53) mismatches resulted in detectable antibodies against an eplet uniquely found on DR53 antigens. Donor-specific DQB mismatches led to detectable anti-DQB antibodies with a frequency of 87%. Their specificity correlated with eplets uniquely found on DQ1-4. The incidence of antibodies induced by 2-digit DQA mismatches was 64% and several eplets appeared to play a dominant role. These findings suggest that both α and β chains of HLA-DQ heterodimers have immunogenic epitopes that can elicit specific antibodies. About one-third of the sera had anti-DP antibodies; they reacted primarily with two DPB eplets and an allelic pair of DPA eplets.These data demonstrate that HLA class II reactive sera display distinct specificity patterns associated with structurally defined epitopes on different HLA-D alleles.

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“…Recent studies (15)(16)(17)(18) have demonstrated that HLA alleles are associated with certain idiopathic renal diseases, including those detected in previous studies (19,20).…”

Section: Controlsmentioning

confidence: 99%

Association of human leukocyte antigen gene polymorphism and mesangial proliferative glomerulonephritis in a large population-based study

et al. 2013

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Abstract. The aim of the present study was to investigate the association of human leukocyte antigen (HLA) gene polymorphism and clinical phenotypes of patients with mesangial proliferative glomerulonephritis (MsPGN). The genotyping of HLA-A, HLA-B and HLA-DRB1 alleles was detected in 1,536 consecutive MsPGN patients during the previous five years and 2,027 age-and gender-matched healthy individuals by using the polymerase chain reaction-sequence-specific primers method. The clinical and pathological data of the patients were collected and the genotype frequencies (GF) and odds ratio (OR) were analyzed. The allele frequencies of HLA-A*23, A*25, B*15, B*40, B*53 and DRB1*18 were significantly higher in MsPGN patients than in the controls (P<0.05). These alleles were considered as the suspected susceptibility genes (SSG) for MsPGN. Of note, results of the follow-up survey study demonstrated poorer prognosis of patients with SSG than those without SSG.

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Post-Transplant HLA class II Antibodies and High Soluble CD30 Levels are Independently Associated with Poor Kidney Graft Survival

Cited by 64 publications

References 35 publications

Soluble CD30 Measured After Lung Transplantation Does Not Predict Bronchiolitis Obliterans Syndrome in a Tacrolimus/Mycophenolate Mofetil–based Immunosuppressive Regimen

Soluble CD30 Measured After Lung Transplantation Does Not Predict Bronchiolitis Obliterans Syndrome in a Tacrolimus/Mycophenolate Mofetil–based Immunosuppressive Regimen

Retransplant candidates have donor-specific antibodies that react with structurally defined HLA-DR,DQ,DP epitopes

Association of human leukocyte antigen gene polymorphism and mesangial proliferative glomerulonephritis in a large population-based study

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