2017
DOI: 10.1038/cdd.2017.139
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Abstract: The tumor suppressor p53 is a transcription factor that regulates the expression of a range of target genes in response to cellular stress. Adding to the complexity of understanding its cellular function is that in addition to the full-length protein, several p53 isoforms are produced in humans, harboring diverse expression patterns and functionalities. One isoform, Δ40p53, which lacks the first transactivation domain including the binding region for the negative regulator MDM2, was shown to be a product of al… Show more

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Cited by 41 publications
(37 citation statements)
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“…The D40p53 isoform is then capable of hetero-tetramerizing with the full length p53, attenuating downstream transcriptional activities. We showed that this negative feedback mechanism is particularly pronounced under conditions of oxidative stress, when the common MDM2-mediated regulation of p53 is disrupted while 20S proteasome activity is increased [5].…”
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confidence: 84%
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“…The D40p53 isoform is then capable of hetero-tetramerizing with the full length p53, attenuating downstream transcriptional activities. We showed that this negative feedback mechanism is particularly pronounced under conditions of oxidative stress, when the common MDM2-mediated regulation of p53 is disrupted while 20S proteasome activity is increased [5].…”
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confidence: 84%
“…Recently, we and others have demonstrated that the activity of 20S proteasome is not restricted to complete degradation of its protein substrates, but rather there are proteins that the 20S proteasome cleaves at specific sites to generate functional cleavage products ( Figure 1B). This process influences diverse cellular pathways such as transcription, protein synthesis and the response to cellular stress [2][3][4][5][6].…”
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confidence: 99%
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“…∆40p53α at low levels increased p53α's transactivation capacity, but at higher levels, inhibited p53α's anti-proliferative effects [80]. Tetramers consisting of p53α and ∆40p53α isoforms were a more stable complex compared to a purely p53α complex [82]. One possible mechanism is that the ∆40p53α isoforms lack TAD1 precluding them from MDM2 mediated degradation [21,24].…”
Section: Cellular Function Involving P53 Isoforms Cell Line/model(s) mentioning
confidence: 99%
“…The D40, D133, and D160 isoforms of p53 protein lack the first 39, 132, and 159 aa, respectively. Translation of the D40p53 protein, also known as p44, is regulated by the intracellular domain of the amyloid precursor protein (34), a polypyrimidine tract binding protein, as well as miR-1285 (35) and 20S proteasome-mediated cleavage (36). D133p53 transcript generates 2 different p53 isoforms, D133p53 and D160p53 (37).…”
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confidence: 99%