Post-prandial endothelial dysfunction in hypertriglyceridemic subjects: Molecular mechanisms and gene expression studies

Norata, Giuseppe Danilo; Grigore, Liliana; Raselli, Sara; Redaelli, L.; Hamsten, Anders; Maggi, F.M.; Eriksson, Per; Catapano, Alberico L.

doi:10.1016/j.atherosclerosis.2006.09.015

Cited by 127 publications

(90 citation statements)

References 23 publications

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“…Furthermore, postprandial TRL has been shown to stimulate several proinflammatory genes, such as interleukin-6, intercellular adhesion molecule-1, etc. [49]. Apo C-III is a proinflammatory and proatherogenic protein.…”

Section: Pathophysiology Of Triglyceride In Cardiovascular Diseasementioning

confidence: 99%

The Role of Triglyceride in Cardiovascular Disease in Asian Patients with Type 2 Diabetes - A Systematic Review

Chen

Tseng

2013

Rev Diabet Stud

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Section: Pathophysiology Of Triglyceride In Cardiovascular Diseasementioning

confidence: 99%

The Role of Triglyceride in Cardiovascular Disease in Asian Patients with Type 2 Diabetes - A Systematic Review

Chen

Tseng

2013

Rev Diabet Stud

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“…Such residual risk may reflect aspects of atherogenesis not captured by LDL‐C, including effects of very‐low‐density lipoproteins (VLDLs) and their contents (cholesterol and triglycerides) 5, 6, 7, 8, 9. Enzymatic hydrolysis of VLDL results in the formation of smaller, cholesterol‐enriched lipoprotein particles,5, 10, 11 which experimental studies suggest could contribute to the development of ASCVD 5, 7, 10, 12, 13, 14, 15, 16. Clinically, however, there has been uncertainty as to whether ASCVD events could be further reduced by reducing these triglyceride‐rich lipoproteins, with several neutral trials examining this strategy to date 10, 17…”

mentioning

confidence: 99%

Residual Risk of Atherosclerotic Cardiovascular Events in Relation to Reductions in Very‐Low‐Density Lipoproteins

Lawler

Akinkuolie

Harada

et al. 2017

JAHA

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BackgroundIt is uncertain whether pharmacological reductions in very‐low‐density lipoproteins (VLDLs), and their component triglyceride and cholesterol could reduce residual risk of atherosclerotic cardiovascular disease (ASCVD) events among individuals in whom low‐density lipoprotein cholesterol (LDL‐C) has been adequately lowered. We examined whether individuals with greater on‐statin reductions in VLDL‐related measures—beyond reductions in LDL‐C—were at further reduced risk of ASCVD.Methods and ResultsIn 9423 participants in the JUPITER (Justification for the Use of Statins in Prevention) trial (NCT00239681), at baseline and on statin we measured standard lipids, 400‐MHz proton nuclear magnetic resonance spectroscopy‐measured VLDL particle subclasses (small, medium, and large VLDL lipoprotein particle concentration), and total VLDL cholesterol mass. Compared with individuals allocated to placebo, we examined risk of incident ASCVD (N=211) among statin‐allocated participants who achieved minimal (

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“…The presented study did not detect any correlation between FMD and ADMA which was shown to cause endothelial damage in different population of patients. There are many studies showing concordance between ADMA levels and endothelial dysfunction in non-uremic patients (16)(17)(18)(19). It is known that ADMA level increases as renal functions decrease reaching very high levels in case of ESRD (20).…”

Section: Discussionmentioning

confidence: 99%

Flow-Mediated Dilatation and Asymmetric Dimethylarginine Do Not Predict Mortality in Peritoneal Dialysis Patients

Uzun¹,

Karadağ²,

Gürsu³

et al. 2017

Haseki

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Akım Aracılı Dilatasyon ve Asimetrik Dimetilargi Periton Diyalizi Hastalarında Mortalite Prediktörü DeğildirAim: Asymmetric dimethylarginine (ADMA) is associated with increased coronary artery disease risk through endothelial dysfunction in dialysis patients. We aimed to investigate the role of flow-mediated dilatation (FMD), a non-invasive indicator of endothelial function, and ADMA in mortality in peritoneal dialysis (PD) patients.Methods: PD patients aged 18-80 years; with dialysis duration of at least three months were included. FMD measurement and ADMA levels were recorded. Outcome of the patients on the third year were analyzed with binary logistic analyses. Results:The mean age of the 55 patients was 53±15 years and the mean follow-up duration was 36 months. Mean FMD and ADMA levels were 10.6±6.4% and 81.8±48.0 mol/L, respectively. Eighteen patients died during follow-up. Age, presence of diabetes mellitus and ischemic heart disease, ultrafiltration amount and serum albumin level were related with mortality while gender, weekly Kt/V and ADMA levels were not. There was no significant relationship between ADMA level and FMD (p=0.873). FMD was negatively correlated with systolic and diastolic blood pressures (p=0.001, p<0.001, respectively). Hypertension was found to be the most important single factor determining FMD (p=0.037). Conclusion:Estimating endothelial function by FMD or measuring serum ADMA levels may not be useful for predicting mortality in PD patients.Keywords: Flow mediated dilatation, asymmetric dimethylarginine, endothelial dysfunction, peritoneal dialysis, mortality Amaç: Diyaliz hastalarında asimetrik dimetilarginin (ADMA) endotel disfonksiyonu yoluyla artmış koroner arter hastalığı riski ile ilişkilidir. Bu çalışmada periton diyalizi (PD) hastalarında endotel disfonksiyonunun non-invaziv bir göstergesi olan akım aracılı dilatasyon (AAD) ve ADMA'nın mortalite ile ilişkisini araştırmayı amaçladık.Yöntemler: Çalışmaya 18-80 yaş aralığında, en az üç aydır diyaliz uygulanan PD hastaları dahil edildi. AAD ölçümü ve ADMA düzeyleri kaydedildi. Üçüncü yılda hasta sonlanımlarında "binary lojistik analizi" kullanıldı.Bulgular: Çalışmaya dahil edilen 55 hastanın yaş ortalaması 53±15 yıl, ortalama takip süresi 36 ay idi. Ortalama AAD ve ADMA düzeyleri sırasıyla %10,6±6,4 ve 81,8±48,0 mol/L idi. On sekiz hasta takip sırasında öldü. Yaş, diyabet ve iskemik kalp hastalığı varlığı, ultrafiltrasyon miktarı ve serum albümin düzeyleri mortalite ile ilişkili iken cinsiyet, haftalık Kt/V ve ADMA düzeyleri ilişkili değildi. ADMA düzeyleri ve AAD arasında anlamlı ilişki yoktu (p=0,873). AAD ile klinik parametrelerden sistolik ve diastolik kan basıncı arasında anlamlı negatif korelasyon vardı (p=0,001, p<0,001). Tüm parametreler arasında AAD'yi belirleyen en önemli tek faktör hipertansiyondu (p=0,037).Sonuç: AAD ile endotel fonksiyonunun değerlendirilmesi veya serum ADMA düzeylerinin ölçülmesi periton diyalizi hastalarında mortaliteyi tahmin etmek için yararlı olmayabilir.

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Post-prandial endothelial dysfunction in hypertriglyceridemic subjects: Molecular mechanisms and gene expression studies

Cited by 127 publications

References 23 publications

The Role of Triglyceride in Cardiovascular Disease in Asian Patients with Type 2 Diabetes - A Systematic Review

The Role of Triglyceride in Cardiovascular Disease in Asian Patients with Type 2 Diabetes - A Systematic Review

Residual Risk of Atherosclerotic Cardiovascular Events in Relation to Reductions in Very‐Low‐Density Lipoproteins

Flow-Mediated Dilatation and Asymmetric Dimethylarginine Do Not Predict Mortality in Peritoneal Dialysis Patients

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