Post-operative radiotherapy for ductal carcinoma in situ of the breast

Abstract

Post-operative radiotherapy for ductal carcinoma in situ of the breast (Review)

Assessment of the usefulness of prognostic Van Nuys Prognostic Index in the treatment in ductal carcinoma in situ in 15-year observation

“…The studies proved that radiotherapy improves the results of treatment in all DCIS patients after a breast conserving treatment. Its advantageous impact is proportional to the grade of the recurrence risk and increases with the observation time (results also presented by McCormick et al during 2018 ASTRO Annual Meeting Late-breaking Abstract Selections LBA1 Randomized Trial Evaluating Radiation following Surgical Excision for “Good Risk” DCIS: 12-Year Report from NRG/RTOG 9804) 25 – 30 . The high percentage of recurrences in the low risk group, reported in this study is evidence of the inability of the VNPI to successfully select patients who could safely avoid radiation therapy.…”

Assessment of the usefulness of prognostic Van Nuys Prognostic Index in the treatment in ductal carcinoma in situ in 15-year observation

“…The studies proved that radiotherapy improves the results of treatment in all DCIS patients after a breast conserving treatment. Its advantageous impact is proportional to the grade of the recurrence risk and increases with the observation time (results also presented by McCormick et al during 2018 ASTRO Annual Meeting Late-breaking Abstract Selections LBA1 Randomized Trial Evaluating Radiation following Surgical Excision for “Good Risk” DCIS: 12-Year Report from NRG/RTOG 9804) 25 – 30 . The high percentage of recurrences in the low risk group, reported in this study is evidence of the inability of the VNPI to successfully select patients who could safely avoid radiation therapy.…”

Treatment of Ductal Carcinoma in situ: A Register-Based Study of Norwegian Women Diagnosed between 1995 and 2018

“…Factors associated with RT in our study were lesions’ diameter and van Nuys’ grade; large lesion diameter and high grade associated with higher risk of recurrence, suggesting that health care providers involved in the management of DCIS have selected women for RT based on factors associated with higher risk of recurrence [16, 41, 42]. However, the difficulty remains in identifying the subgroup of women in whom the absolute benefit of treatment of DCIS may be small.…”

AGO Recommendations for the Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2016

“…RT can be omitted in selected patients with a minimal absolute risk of recurrence provided shared decisionmaking and careful information of the patient regarding risks and benefit is provided. This was repeatedly confirmed by a Cochrane analysis of postoperative radiotherapy for DCIS of the breast (LoE 1a, A, AGO ++) [56]. A multigene assay called DCIS Score ® showed promising data to classify patients into 3 dis tinct risk groups (low, intermediate, high).…”

Assessment of the usefulness of prognostic Van Nuys Prognostic Index in the treatment in ductal carcinoma in situ in 15-year observation

“…The studies proved that radiotherapy improves the results of treatment in all DCIS patients after a breast conserving treatment. Its advantageous impact is proportional to the grade of the recurrence risk and increases with the observation time (results also presented by McCormick et al during 2018 ASTRO Annual Meeting Late-breaking Abstract Selections LBA1 Randomized Trial Evaluating Radiation following Surgical Excision for “Good Risk” DCIS: 12-Year Report from NRG/RTOG 9804) 25 – 30 . The high percentage of recurrences in the low risk group, reported in this study is evidence of the inability of the VNPI to successfully select patients who could safely avoid radiation therapy.…”

Treatment of Ductal Carcinoma in situ: A Register-Based Study of Norwegian Women Diagnosed between 1995 and 2018

“…Factors associated with RT in our study were lesions’ diameter and van Nuys’ grade; large lesion diameter and high grade associated with higher risk of recurrence, suggesting that health care providers involved in the management of DCIS have selected women for RT based on factors associated with higher risk of recurrence [16, 41, 42]. However, the difficulty remains in identifying the subgroup of women in whom the absolute benefit of treatment of DCIS may be small.…”

AGO Recommendations for the Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2016

“…RT can be omitted in selected patients with a minimal absolute risk of recurrence provided shared decisionmaking and careful information of the patient regarding risks and benefit is provided. This was repeatedly confirmed by a Cochrane analysis of postoperative radiotherapy for DCIS of the breast (LoE 1a, A, AGO ++) [56]. A multigene assay called DCIS Score ® showed promising data to classify patients into 3 dis tinct risk groups (low, intermediate, high).…”

Assessment of the usefulness of prognostic Van Nuys Prognostic Index in the treatment in ductal carcinoma in situ in 15-year observation

“…The studies proved that radiotherapy improves the results of treatment in all DCIS patients after a breast conserving treatment. Its advantageous impact is proportional to the grade of the recurrence risk and increases with the observation time (results also presented by McCormick et al during 2018 ASTRO Annual Meeting Late-breaking Abstract Selections LBA1 Randomized Trial Evaluating Radiation following Surgical Excision for “Good Risk” DCIS: 12-Year Report from NRG/RTOG 9804) 25 – 30 . The high percentage of recurrences in the low risk group, reported in this study is evidence of the inability of the VNPI to successfully select patients who could safely avoid radiation therapy.…”

Treatment of Ductal Carcinoma in situ: A Register-Based Study of Norwegian Women Diagnosed between 1995 and 2018

“…Factors associated with RT in our study were lesions’ diameter and van Nuys’ grade; large lesion diameter and high grade associated with higher risk of recurrence, suggesting that health care providers involved in the management of DCIS have selected women for RT based on factors associated with higher risk of recurrence [16, 41, 42]. However, the difficulty remains in identifying the subgroup of women in whom the absolute benefit of treatment of DCIS may be small.…”

AGO Recommendations for the Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2016

“…RT can be omitted in selected patients with a minimal absolute risk of recurrence provided shared decisionmaking and careful information of the patient regarding risks and benefit is provided. This was repeatedly confirmed by a Cochrane analysis of postoperative radiotherapy for DCIS of the breast (LoE 1a, A, AGO ++) [56]. A multigene assay called DCIS Score ® showed promising data to classify patients into 3 dis tinct risk groups (low, intermediate, high).…”