Post-neonatal hospitalization and health care costs among IVF children: a 7-year follow-up study

Koivurova, Sari; Hartikainen, Anna-Liisa; Gissler, Mika; Hemminki, Elina; Järvelin, Marjo‐Riitta

doi:10.1093/humrep/dem150

Cited by 45 publications

(31 citation statements)

References 19 publications

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“…However, some reports have suggested that ART children are more likely to have childhood illnesses Källén et al, 2005;Koivurova et al, 2007;Ludwig et al, 2009). A multi-center cohort study encompassing 540 ICSI, 437 IVF, and 538 NC children suggested a significantly higher risk of childhood illness, surgery, requiring medical care, and being admitted to hospital in ART-conceived children.…”

Section: Physical Healthmentioning

confidence: 99%

Long-term follow-up of children conceived through assisted reproductive technology

Wang

Jin

2013

J. Zhejiang Univ. Sci. B

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Children conceived via assisted reproductive technologies (ART) are nowadays a substantial proportion of the population. It is important to follow up these children and evaluate whether they have elevated health risks compared to naturally conceived (NC) children. In recent years there has been a lot of work in this field. This review will summarize what is known about the health of ART-conceived children, encompassing neonatal outcomes, birth defects, growth and gonadal developments, physical health, neurological and neurodevelopmental outcomes, psychosocial developments, risk for cancer, and epigenetic abnormalities. Most of the children conceived after ART are normal. However, there is increasing evidence that ART-conceived children are at higher risk of poor perinatal outcome, birth defects, and epigenetic disorders, and the mechanism(s) leading to these changes have not been elucidated. Continuous follow-up of children after ART is of great importance as they progress through adolescence into adulthood, and new ART techniques are constantly being introduced.

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Section: Physical Healthmentioning

confidence: 99%

Long-term follow-up of children conceived through assisted reproductive technology

Wang

Jin

2013

J. Zhejiang Univ. Sci. B

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“…Another frequently heard argument in favor singleton deliveries involves the allegedly higher costs for twin outcomes after infertility treatments (43)(44)(45)(46)(47)(48). However, once again the literature uses incorrect statistical considerations.…”

Section: The Cost Argumentmentioning

confidence: 99%

Twin pregnancy, contrary to consensus, is a desirable outcome in infertility

Gleicher

Barad

2009

Fertility and Sterility

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“…Other studies compared both IVF singletons with naturally conceived singletons and IVF twins with naturally conceived twins [42-45]. Although these studies provided figures about the long-term health status of IVF twins and IVF singletons, no statistics were presented and no conclusions were drawn regarding the comparison between IVF twins and IVF singletons.…”

Section: Introductionmentioning

confidence: 99%

“…respiratory diseases, pneumonia, obstructive bronchitis, asthma, juvenile arthritis and neurological signs. Another study of Koivurova et al [42] showed that risks of having diagnoses related to diseases affecting the central nervous system were higher for IVF twins. Furthermore, the proportion of children with low weight, low height and inability to perform at least one developmental test was higher in the IVF twin group compared to singletons for several age categories up to three years.…”

Section: Introductionmentioning

confidence: 99%

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Long term costs and effects of reducing the number of twin pregnancies in IVF by single embryo transfer: the TwinSing study

et al. 2010

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BackgroundPregnancies induced by in vitro fertilisation (IVF) often result in twin gestations, which are associated with both maternal and perinatal complications. An effective way to reduce the number of IVF twin pregnancies is to decrease the number of embryos transferred from two to one. The interpretation of current studies is limited because they used live birth as outcome measure and because they applied limited time horizons. So far, research on long-term outcomes of IVF twins and singletons is scarce and inconclusive. The objective of this study is to investigate the short (1-year) and long-term (5 and 18-year) costs and health outcomes of IVF singleton and twin children and to consider these in estimating the cost-effectiveness of single embryo transfer compared with double embryo transfer, from a societal and a healthcare perspective.Methods/DesignA multi-centre cohort study will be performed, in which IVF singletons and IVF twin children born between 2003 and 2005 of whom parents received IVF treatment in one of the five participating Dutch IVF centres, will be compared. Data collection will focus on children at risk of health problems and children in whom health problems actually occurred. First year of life data will be collected in approximately 1,278 children (619 singletons and 659 twin children). Data up to the fifth year of life will be collected in approximately 488 children (200 singletons and 288 twin children). Outcome measures are health status, health-related quality of life and costs. Data will be obtained from hospital information systems, a parent questionnaire and existing registries. Furthermore, a prognostic model will be developed that reflects the short and long-term costs and health outcomes of IVF singleton and twin children. This model will be linked to a Markov model of the short-term cost-effectiveness of single embryo transfer strategies versus double embryo transfer strategies to enable the calculation of the long-term cost-effectiveness.DiscussionThis is, to our knowledge, the first study that investigates the long-term costs and health outcomes of IVF singleton and twin children and the long-term cost-effectiveness of single embryo transfer strategies versus double embryo transfer strategies.

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Post-neonatal hospitalization and health care costs among IVF children: a 7-year follow-up study

Abstract: The incidence of multiple births increases the utilization of post-neonatal health care services and costs among IVF children in comparison to naturally conceived children. Increased hospitalization and costs were also seen among IVF singletons.

Cited by 45 publications

References 19 publications

Long-term follow-up of children conceived through assisted reproductive technology

Long-term follow-up of children conceived through assisted reproductive technology

Twin pregnancy, contrary to consensus, is a desirable outcome in infertility

Long term costs and effects of reducing the number of twin pregnancies in IVF by single embryo transfer: the TwinSing study

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