Post-Mortem Cardiac Magnetic Resonance for the Diagnosis of Hypertrophic Cardiomyopathy

Aquaro, Giovanni Donato; Guidi, Benedetta; Biondi, Federico; Chiti, Enrica; Santurro, Alessandro; Scopetti, Matteo; Turillazzi, Emanuela; Paolo, Marco Di

doi:10.20944/preprints202011.0240.v1

Cited by 6 publications

(2 citation statements)

References 9 publications

(11 reference statements)

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“…In adult subjects, HCM is characterized by a wall thickness ≥ 15 mm in one or more LV myocardial segments, measured by different imaging technique types (i.e., echocardiography, computed tomography, or cardiac magnetic resonance). More limited hypertrophy (13–14 mm) in different LV sections can be diagnostic in first-degree relatives of a patient with HCM [ 19 , 20 , 21 ]. HCM is an autosomal dominant disease, characterized by high heterogeneity and variable expressivity.…”

Section: Mirnas As Potential Biomarkers In Hypertrophic Cardiomyopathymentioning

confidence: 99%

MicroRNAs in Hypertrophic, Arrhythmogenic and Dilated Cardiomyopathy

et al. 2021

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MicroRNAs (miRNAs) are a class of non-coding RNAs of about 20 nucleotides in length, involved in the regulation of many biochemical pathways in the human body. The level of miRNAs in tissues and circulation can be deregulated because of altered pathophysiological mechanisms; thus, they can be employed as biomarkers for different pathological conditions, such as cardiac diseases. This review summarizes published findings of these molecular biomarkers in the three most common structural cardiomyopathies: human dilated, arrhythmogenic and hypertrophic cardiomyopathy.

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Section: Mirnas As Potential Biomarkers In Hypertrophic Cardiomyopathymentioning

confidence: 99%

MicroRNAs in Hypertrophic, Arrhythmogenic and Dilated Cardiomyopathy

et al. 2021

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“…In addition to its diagnostic capabilities, T1 (and T2) mapping may offer further insight into these pathological processes. This case highlights the importance of multimodality imaging in differentiating hypertrophic cardiomyopathies [5][6][7][8]. 4.…”

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Unraveling an Unusual Phenocopy of Hypertrophic Cardiomyopathy: MELAS Syndrome

et al. 2021

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The mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is an uncommon cause of cardiac hypertrophy, fibrosis, and dysfunction. It shares similar features to numerous other causes of left ventricular hypertrophy, and therefore, because of its rarity, may not be immediately considered as a diagnosis. Prompt recognition of clinical and cardiac imaging features may expedite diagnosis and management. We report the case of a 38-year-old man admitted with neurological symptoms and in whom the diagnostic workup led to the diagnosis of MELAS syndrome with cardiac involvement.

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Sudden Cardiac Death and Ex-Situ Post-Mortem Cardiac Magnetic Resonance Imaging: A Morphological Study Based on Diagnostic Correlation Methodology

et al. 2022

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During the last years, post-mortem imaging has gradually been assumed within research in the field of forensic pathology. This role appears to be clearly and simply applied in the trauma field with the use of conventional radiography or Post Mortem Computed Tomography (PMCT). Recently, particular attention was paid to cardiovascular imaging using Post Mortem Magnetic Resonance Imaging (PMMRI). The present experimental study aims to: (i) confirm the efficacy of a Post Mortem Cardiac Resonance Imaging (PMCRI) study protocol for the study of human hearts collected during the autopsy; (ii) apply the defined protocol on subjects who died of “SCD (sudden cardiac death)”, to identify alterations that could guide subsequent sampling. Two hearts of healthy subjects (A: male 22 years; B: female 26 years), who died from causes other than SCD were collected and compared to hearts that belonged to SCD individuals (C: male, 47 years old; D: female, 44 years old; E: male; 72 years old). The exams were performed on a 1.5 T scanner (Philips Intera Achieva, Best, the Netherlands) on hearts collected during autopsy and after a 30-day formalin fixation. Two readers analyzed the obtained images blindly and after randomization. From the comparison between the data from imaging and the macroscopic and histological investigations carried out, the present study proved the effectiveness of a PMMRI protocol to study ex-situ hearts. Moreover, it suggested the following semeiology in post-mortem SCD cases: the hyperintense area with indistinct margins in the Short Tau Inversion Recovery (STIR) sequence was linked to edema or area of pathological fibers, whereas the hypointense area in the T2-FFE sequences was linked to fibrosis. PMMRI can provide a valuable benefit to post-mortem investigations, helping to distinctly improve the success rate of histological sampling and investigations, which remains the gold standard in the diagnosis of sudden death.

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Post-Mortem Cardiac Magnetic Resonance for the Diagnosis of Hypertrophic Cardiomyopathy

Cited by 6 publications

References 9 publications

MicroRNAs in Hypertrophic, Arrhythmogenic and Dilated Cardiomyopathy

MicroRNAs in Hypertrophic, Arrhythmogenic and Dilated Cardiomyopathy

Unraveling an Unusual Phenocopy of Hypertrophic Cardiomyopathy: MELAS Syndrome

Sudden Cardiac Death and Ex-Situ Post-Mortem Cardiac Magnetic Resonance Imaging: A Morphological Study Based on Diagnostic Correlation Methodology

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