Post-COVID Factor X Deficiency: A Case Report From Pakistan

Humayun, Omama; Durrani, Talha; Ullah, Rafiq; Qayum, Ihtisham; Khan, M. Ijaz

doi:10.7759/cureus.31473

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…COVID-19 has been associated with thromboembolisms but has rarely been associated with hemorrhagic events, usually explained by disseminated intravascular coagulation and thrombocytopenia. There has only been one other case reported of post-COVID-19-induced AFXD [ 9 ]. In the literature, deficiencies of factors V, VIII, XI and XII have been reported due to COVID-19 [ 10 , 11 , 12 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

Acquired Factor X Deficiency without Amyloidosis Presenting with Massive Hematuria: A Case Report and Review of the Literature

et al. 2023

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Acquired factor X deficiency is a rare diagnosis, especially without the association of other co-existing conditions such as amyloidosis. The authors report the case of a 34-year-old male with severe frank hematuria found to have markedly prolonged prothrombin time and activated partial thromboplastin time. A mixing study showed correction utilizing normal plasma and a coagulation panel testing revealed decreased factor X activity. The patient was treated with multiple blood transfusions, fresh frozen plasma, high-dose pulse steroids, and rituximab. The patient’s condition improved during his 21-day hospital stay and was followed up every 2 weeks for 3 months. The patient’s factor X level recovered after two weeks of discharge with no other hemorrhagic episodes.

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Section: Discussionmentioning

confidence: 99%

Acquired Factor X Deficiency without Amyloidosis Presenting with Massive Hematuria: A Case Report and Review of the Literature

et al. 2023

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“…Approximately one-third of cases remain idiopathic. Interestingly, two recent cases described a factor X deficit following SARS-CoV-2 infection, although they could not demonstrate an inhibitory effect [ 11 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

Circulating Inhibitor against Factor X: A Rare Cause of Hemorrhagic Diathesis

Rossignon,

Grandjean,

Claessens

et al. 2023

Case Reports in Hematology

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Acquired coagulopathies resulting from factor X deficiency are rare and typically associated with amyloidosis or plasma cell dyscrasia. Factor X plays a pivotal role in the coagulation cascade, converting prothrombin into thrombin and facilitating the formation of fibrinogen and thrombus. While its occurrence following common infections is extremely rare, isolated cases have been documented. We present a rare case of bleeding diathesis in a patient with community-acquired pneumonia, where prolonged activated partial thromboplastin time (aPTT) and prothrombin time (PT) led to the diagnosis of an infectious-triggered acquired circulating inhibitor targeting factor X. Prompt treatment with methylprednisolone effectively controlled the inhibitor without recurrence. This case report provides insights into the diagnostic strategies, differential algorithm, and therapeutic approaches for managing this rare coagulopathy.

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Post-COVID Factor X Deficiency: A Case Report From Pakistan

Cited by 2 publications

References 13 publications

Acquired Factor X Deficiency without Amyloidosis Presenting with Massive Hematuria: A Case Report and Review of the Literature

Acquired Factor X Deficiency without Amyloidosis Presenting with Massive Hematuria: A Case Report and Review of the Literature

Circulating Inhibitor against Factor X: A Rare Cause of Hemorrhagic Diathesis

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