Possible role of preproghrelin gene polymorphisms in susceptibility to bulimia nervosa

Ando, Takao; Kobashi, Gén; Naruo, Tetsuro; Okabe, Kenjiro; Takii, Masato; Kawai, Keisuke; Konjiki, Fujiko; Takei, Michiko; Oka, Takahiro; Takeuchi, Kaori; Masuda, Akinori; Ozaki, Norio; Suematsu, Hiroyuki; Denda, Kenzo; Kurokawa, Nobuo; Itakura, Kotarou; Yamaguchi, Chikara; Kono, Masaki; Suzuki, Tatsuyo; Nakai, Yoshikatsu; Nishizono-Maher, Aya; Koide, Masanori; Murakami, Ken; Nagamine, Kiyohide; Tomita, Y.; Ookuma, Kazuyoshi; Tomita, Katsutoshi; Tonai, Eita; Ooshima, Akira; Ishikawa, Takahiro; Ichimaru, Yuhei

doi:10.1002/ajmg.b.30387

Cited by 57 publications

(44 citation statements)

References 31 publications

(32 reference statements)

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“…It must be noted, that the study of such genetic locus among Ukrainians was not carried out, and we first inform about the frequencies of alleles of р. [30,31]. The frequency of Met72 allele in our sample is 21 %, a bit higher than the data, given by НарМар (15,6 %, N = 90).…”

Section: Discussioncontrasting

confidence: 77%

Р. Leu72met Mutation of Ghrelin GHRL Gene in Children With Gastroesophageal Reflux Disease

Dats-Opoka

Makukh

Hnateyko

2017

EUREKA: Health Sciences

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Gastroesophageal disease (GERD) is the one of most spread diseases that injures an esophagus. Taking into account the large number of factors that can cause GERD development already in child age, including genetic predisposition, it is necessary to analyze each of them in detail. Aim of this work was to analyze a frequency and possible association type of р. Leu72Met mutation of GHRL gene in children with gastroesophageal reflux disease. The analysis of clinical parameters and course of disease in the group of 100 schoolchildren with GERD was carried out. The molecular-genetic study of c.214C>A locus of GHRL gene by CPR method (rs696217) was carried out in patients with GERD and 40 healthy children from the control group. In 82% of children with GERD was revealed a GHRL 214СС (Leu/Leu) homozygous genotype, at 58% among children from the control group. GHRL 214СА (Leu/ Met) genotype was registered three times more seldom in children of the studied group comparing with ones from the control group: 15,0% and 42,5%, respectively. It was established, that GHRL 214CС genotype presence conditions the increase of GERD development risk in 3,4 times. On the contrary, GHRL 214CА genotype manifests a reliable protective effect that is essentially decreased GERD development risk in a child at such genotype – 0,24 comparing with a conventional unit. There was established alleles and genotypes distribution of c.214C>A (р.Leu72Met) locus of GHRL gene in children with GERD. GHRL 214CС genotype is associated with threefold increase of GERD risk development. Gender differences as to GERD development risk at different genotypes of ghrelin gene were established. At GHRL 214СС (Leu/Leu) genotype the relative GERD risk for boys increased in more than 6 times. There were not established any differences in alleles and genotypes distribution depending on erosive or surface inflammatory changes of a gastrointestinal tract mucosa.

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Section: Discussioncontrasting

confidence: 77%

Р. Leu72met Mutation of Ghrelin GHRL Gene in Children With Gastroesophageal Reflux Disease

Dats-Opoka

Makukh

Hnateyko

2017

EUREKA: Health Sciences

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“…Moreover, different pro-ghrelin gene polymorphisms have been linked to obesity, and to bulimia nervosa purging individuals (Ando et al 2006;Gueorguiev et al 2002;Korbonits et al 2002;Ukkola et al 2001;Vivenza et al 2004;Vartiainen et al 2006) as well as methamphetamine withdrawal .…”

Section: The Central Ghrelin Signalling System Is Required For Rewardmentioning

confidence: 99%

The role of the central ghrelin system in reward from food and chemical drugs

Dickson

Egecioglu

Landgren

et al. 2011

Molecular and Cellular Endocrinology

217

168

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Here we review recent advances that identify a role for the central ghrelin signalling system in reward from both natural rewards (such as food) and artificial rewards (that include alcohol and drugs of abuse). Whereas ghrelin emerged as a stomach-derived hormone involved in energy balance, hunger and meal initiation via hypothalamic circuits, it now seems clear that it also has a role in motivated reward-driven behaviours via activation of the so-called "cholinergic-dopaminergic reward link". This reward link comprises a dopamine projection from the ventral tegmental area (VTA) to the nucleus accumbens together with a cholinergic input, arising primarily from the laterodorsal tegmental area. Ghrelin administration into the VTA or LDTg activates the "cholinergicdopaminergic" reward link, suggesting that ghrelin may increase the incentive value of motivated behaviours such as reward-seeking behaviour ("wanting" or "incentive motivation"). Further, direct injection of ghrelin into the brain ventricles or into the VTA

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“…It is noticeable that the studies were still inconclusive when the GHRL gene is investigated, these studies show different positive and negative associations with different EDs diagnoses 73,81,82,84,86 . However, when they analyzed the genes of the GHS-R and of the GOAT some studies have found a positive association between polymorphisms and the EDs 79 .…”

Section: C60t Asp20asp Rs2232165mentioning

confidence: 99%

Ghrelin and eating disorders

Fabbri¹,

Deram²,

Kerr³

et al. 2015

Arch. Clin. Psychiatry (São Saulo)

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Background: Ghrelin is a potent hormone with central and peripheral action. This hormone plays an important role in the regulation of appetite, food intake, and energy balance. Studies have suggested that ghrelin is involved with eating disorders (ED), particularly bingeing and purging. Genetic variants have also been studied to explain changes in eating behavior. Methods: We conducted a literature review; we searched PubMed, Scientific Electronic Library Online (SciELO), and LILACS databases using the keywords "eating disorder", "ghrelin", "polymorphism", "anorexia nervosa", "bulimia nervosa", "binge eating disorder", and their combinations. We found 319 articles. Thirty-nine articles met the inclusion criteria. Results: High levels of ghrelin were found in patients with anorexia nervosa (AN), especially in the purging subtype (AN-P). There was also a positive correlation between fasting ghrelin level and frequency of episodes of bingeing/purging in bulimia nervosa (BN) and the frequency of bingeing in periodic binge eating disorder (BED). Some polymorphisms were associated with AN and BN. Conclusion: Changes in ghrelin levels and its polymorphism may be involved in the pathogenesis of EDs; however, further studies should be conducted to clarify the associations.

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Possible role of preproghrelin gene polymorphisms in susceptibility to bulimia nervosa

Cited by 57 publications

References 31 publications

Р. Leu72met Mutation of Ghrelin GHRL Gene in Children With Gastroesophageal Reflux Disease

Р. Leu72met Mutation of Ghrelin GHRL Gene in Children With Gastroesophageal Reflux Disease

The role of the central ghrelin system in reward from food and chemical drugs

Ghrelin and eating disorders

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