2010
DOI: 10.4149/neo_2010_05_429
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Abstract: B-cell chronic lymphocytic leukemia (B-CLL) represents a heterogeneous disease with a very variable outcome. The reliable prognosis of this disease at the time of initial diagnosis is difficult to predict. The purpose of this preliminary study was to utilize the nucleolar morphology and to investigate the incidence of main nucleolar types in leukemic lymphocytes in B-CLL patients to assess their possible predictive value for the disease outcome, in correlation with immunophenotype parameters. The evaluation of… Show more

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Cited by 6 publications
(4 citation statements)
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“…Such lymphocytes in chronic lymphocytic leukemia were also observed previously. However, that observation was not based on the heterochromatin features, but on the nucleolar size and RNA distribution [34]. In addition, the decreasing heterochromatin condensation in the nuclear periphery was noted in stimulated T lymphocytes during experimental blastic transformation induced by phytohemaglutinin [31].…”
Section: Discussionmentioning
confidence: 95%
“…Such lymphocytes in chronic lymphocytic leukemia were also observed previously. However, that observation was not based on the heterochromatin features, but on the nucleolar size and RNA distribution [34]. In addition, the decreasing heterochromatin condensation in the nuclear periphery was noted in stimulated T lymphocytes during experimental blastic transformation induced by phytohemaglutinin [31].…”
Section: Discussionmentioning
confidence: 95%
“…It shoud be added that leukemic lymphocytes with large nucleoli were also considered to be unfabourable prognostic markers for patients resistant to the chemotherapy. [29]. "Large active nucleoli" with multiple fibrillar centers are known to be characteristic for proliferating cells [5,7].…”
Section: Discussionmentioning
confidence: 99%
“…The nucleated blood cells and especially leukemia lymphocytes of chronic lymphocytic leukemia represent a very convenient model for such study because they are present in the peripheral blood or bone marrow in a satisfactory number and their maturation stages including the nucleolar morphology and size are well known [7][8][9]. It is also generally known that mature lymphocytes are mostly in G0 or early G1 phase of the cell cycle.…”
mentioning
confidence: 99%