Possible involvement of beta-adrenergic receptors in the enhancement of nocturnal pineal N-acetyltransferase activity due to parathion administration

Attia, A. A.

doi:10.1016/s0300-483x(99)00106-7

Cited by 6 publications

(3 citation statements)

References 25 publications

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“…(2,3) They produce a wide range of toxicity in mammals by inhibiting acetylcholinesterase, and the consequent accumulation of the neurotransmitter acetylcholine in synaptic junctions leading to excessive stimulation of the postsynaptic cells resulting in cholinergic toxicity. (4,5) Many alterations have been observed in the organs of animals due to exposure to organophosphorus insecticides, (6) especially in the liver, (7,8) and the kidney. (9) Malathion, a prominent organophosphate insecticide, is extensively used to control pests.…”

Section: Introductionmentioning

confidence: 99%

The Potential Protective and Therapeutic Effects of Aloe Vera Juice on Malathion Induced Hepatotoxicity in Rabbits

Al-Shinnawy

Hassan

Ismail

et al. 2014

EJHM

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Background: the potential protective and therapeutic effects of Aloe vera juice against malathion induced hepatotoxicity were evaluated in this study. Material and methods: one hundred twelve young male rabbits were used ; they were allocated into two sets of experiments included rabbits treated for short (7 days) and long (21 days) periods. Animals of the first set (short period of treatment) were divided into eight groups; each consisted of four treated groups and four control groups (each treated group had its own control). The animals of the first group were orally dosed with Aloe vera juice (0.84 ml/kg b. wt.). Rabbits of the second group were orally dosed with malathion (5 mg/kg b. wt.). The third group animals were dosed orally with malathion concomitant with Aloe vera juice (this group served as the protective group). Animals of the fourth group were dosed orally with malathion; for 7 days followed by Aloe vera juice for the same period (this group served as the therapeutic group). The design of the second set (long period of treatment) was exactly similar to that of the short period experiments (divided into eight groups; four treated and four control groups) except the duration of treatment which extended to 21 days. Animals of the control groups of Aloe vera treated rabbits were dosed with distilled water, and those of malathion treated animals were dosed with the solvent of the insecticide. All the animals were sacrificed, blood samples were collected and the serum was used to determine the levels of hepatic enzyme markers: lactate dehydrogenase (LDH), aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT) and alkaline phosphatase (ALP) as well as the total bilirubin. Results: the results revealed that treatment of rabbits with malathion caused marked increase in the serum activity of LDH, ASAT, ALAT and ALP in treated rabbits. Administration of Aloe vera juice (in the protective and therapeutic groups) was found to be effective in lowering the elevated activities of these enzymes to approximate near normal levels for both the short and long periods of treatment, especially in the activity of LDH, ASAT and ALP. The present results suggested that Aloe vera juice has ameliorative effects against hepatotoxicity produced by malathion in the treated rabbits.

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Section: Introductionmentioning

confidence: 99%

The Potential Protective and Therapeutic Effects of Aloe Vera Juice on Malathion Induced Hepatotoxicity in Rabbits

Al-Shinnawy

Hassan

Ismail

et al. 2014

EJHM

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“…It is known that N-acetyl transferase (NAT) and hydroxyindole-o-methyl transferase (HIOMT) are required respectively for conversion of serotonin to NAS and NAS to melatonin (19,20). There are evidences that NAT (21) and HIOMT activities are enhanced in stress. Thus, elevation of serotonin and melatonin levels in metabolic stress or after arecoline treatment in metabolic stress could be due to enhanced activities of NAT and HIOMT in rats.…”

Section: Discussionmentioning

confidence: 99%

Arecoline Cannot Alter Pineal-Testicular Responses to Metabolic Stress in Wistar Rats

et al. 2018

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Context. Betel nut is consumed by millions of people for stress reduction and increased capacity to work. One of its components is arecoline which is useful for Alzheimer and schizophrenia; it also influences endocrine and gonadal functions.Objective. Objective is to examine whether arecoline can influence pineal-testicular function in metabolic stress.Design. Rats were deprived of food or water or treated them with arecoline, each separately for 5 days.Subjects. Pineal and testis with sex accessories were studied.Methods. Ultrastructural (pineal, testis, Leydig cells and prostate), hormonal (melatonin and testosterone) and other parameters (fructose and sialic acid) were examined. Pineal indoleamines were quantitated by fluorometric method; testosterone by ELISA, and carbohydrate fractions by spectrophotometric methods.Results. Inanition/ water deprivation caused pineal stimulation ultrastructurally (with enlarged synaptic ribbons) and elevation of melatonin level, but reproductive dysfunction by ultrastructural degeneration of Leydig cells and prostate with fall of testosterone, fructose and sialic acid concentrations. Arecoline treatment showed reversed changes to those of metabolic stress, but arecoline treatment in metabolic stress showed same results as in metabolic stress.Conclusion. The findings suggest that arecoline cannot alter the action of metabolic stress on pineal-testicular activity in rats.

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“…Organophosphorus insecticides are extensively used for a diverse agricultural and public health practices [2] , producing toxicity in mammals by hindering acetylcholinesterase activity resulting in accumulation of the acetylcholine neurotransmitter in synaptic junctions and leading to cholinergic toxicity by extreme stimulation of the postsynaptic cells [3,4] . The pyrethroids are very stable compounds and systemic toxicity arises by subsequent ingestion.…”

Section: Introductionmentioning

confidence: 99%

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2017

J. Entomol. Zool. Stud.

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The present study was undertaken to know the hematological alterations in the rabbits following oral intoxication with malathion and cypermethrin at the dose of 75 mg/Kg body weight for seven days by using gavage. Rabbits were divided into three groups A, B and C comprised of three animals each. Group A was considered as the control group and was kept as such without any intoxication. Group B was the malathion intoxicated group while C was the cypermethrin intoxicated group. Results demonstrated the negative effects of both insecticides. Malathion produced 95% increase in WBCs, 4.9% in RBCs, 3.34% in HCT, 3.2% in MCHC, while -1.1% decrease in Hb, -1.3% in MCV, -3.7% in MCH and -16.12% in PLT was also recorded. Cypermethrin caused an increase of 142% in WBCs, 17.45% in RBCs, 4.21% in MCHC, 1.24% in MCH, and 5.76% in PLT, and a decrease of -5.8% in Hb, -0.5% in MCV and -5.5% in HCT level. In conclusion both the insecticides induced alterations in hematological indices and are suggested to be neurotoxic with leukemic tendency for rabbits and other vertebrates including human.

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Possible involvement of beta-adrenergic receptors in the enhancement of nocturnal pineal N-acetyltransferase activity due to parathion administration

Cited by 6 publications

References 25 publications

The Potential Protective and Therapeutic Effects of Aloe Vera Juice on Malathion Induced Hepatotoxicity in Rabbits

The Potential Protective and Therapeutic Effects of Aloe Vera Juice on Malathion Induced Hepatotoxicity in Rabbits

Arecoline Cannot Alter Pineal-Testicular Responses to Metabolic Stress in Wistar Rats

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