Possible Determinants of Plasma Renin Activity in Infant Rats

Solomon, Sidney; Iaina, Adrian; Eliahou, H. E.

doi:10.3181/00379727-153-39535

Cited by 9 publications

(4 citation statements)

References 9 publications

(11 reference statements)

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“…Although we did not study the contribution of other possible age modulatory factors of PRA and PA such as catecholamines (Hiner et af., 1976;Jose et af., 1971;Solomon et al, 1976) or ACTH (Hayduk et al, 1973), the present findings suggest that changes in sodium intake are responsible for determining the renin profile during childhood (age 4-1 6), while in modulation of PA during childhood, other factors besides PRA participate.…”

Section: Discussionmentioning

confidence: 55%

Sodium, Potassium and Age: Possible Determinants of Plasma Renin Activity and Aldosterone During Childhood (Age 4–16)

Goldfarb

Sack

Iaina

et al. 1981

Clinical Endocrinology

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The renin-angiotensin-aldosterone system was studied in fifty healthy children aged 4-16 years under normal sodium and potassium intake. The plasma renin activity (PRA) and plasma aldosterone (PA) decreased with age: r = -0.30, P less than 0.05 for plasma renin activity and r = -0.33, P less than 0.05 for plasma aldosterone. Significant negative correlation was obtained between plasma renin activity and the 24-h urinary sodium excretion; r = -0.40, P less than 0.01. This relationship remained significant when the daily urinary sodium excretion was corrected for 1.73 m2 body surface area (BSA); r = -0.40, P less than 0.01. Using the multivariance analysis, plotting the plasma renin activity against the two combined parameters (24-h urinary sodium excretion and age), no improvement was obtained (r = 0.38, P greater than 0.05). This finding suggests that during childhood, sodium rather than age has a major modulatory role on plasma renin activity. With advancing age the plasma aldosterone showed a significant positive correlation coefficient with plasma renin activity(r = 0.29, P less than 0.05). Multivariance analysis between plasma aldosterone and the two combined parameters, Plasma renin activity and age, significantly improved the correlation coefficient (r = 0.42, P less than 0.05) suggesting that both plasma renin activity and age play a dominant modulatory role in the control of plasma aldosterone during childhood. Neither 24-h urinary sodium excretion, nor 24-h urinary potassium excretion, improved the multiple correlation coefficient with plasma aldosterone when added to plasma renin activity and age.

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Section: Discussionmentioning

confidence: 55%

Sodium, Potassium and Age: Possible Determinants of Plasma Renin Activity and Aldosterone During Childhood (Age 4–16)

Goldfarb

Sack

Iaina

et al. 1981

Clinical Endocrinology

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“…2). Solomon et al (23) observed that saralasin increased plasma renin activity in 2-week-old rats, while Siegal et al (19) found that angiotensin II infusion produced a decrease in plasma renin activity in newborn lambs. Thus, the absence of a negative feedback system is not responsible for the elevated plasma renin activity in newborn piglets.…”

Section: Discussionmentioning

confidence: 99%

Regulation of Plasma Renin in Developing Piglets

Jl¹,

Jb²,

Bailie³

1980

Dev Pharmacol Ther

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Plasma renin activity (PRA) was determined in conscious piglets between 1 and 50 days of age before and after treatment with saralasin and indornethacin. Following drug treatment, animals were volume expanded with isotonic saline. Saralasin increased PRA in piglets 1--5 and 18-22 days of age but not 45-50 days. Neither indome thacin nor VE changed PRA at any age, Volume expansion of saralasin- and indomethacin-treated pigs decreased PRA. Neonatal hyperrenincmia does not appear to result from renin release stimulated by prostaglandins or by the absence of angiotensin II negative feedback. In addition, the plasma half-Iife of renin was not different between young and more mature animals suggesting that immature hepatic metabolism of renin cannot be entirely responsible for the high PRA in newborns.

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“…The modification for measurement of PRA has been de scribed previously (22). Comparison of all means were made using Student's t test (19).…”

Section: Methodsmentioning

confidence: 99%

Postnatal Changes in Plasma and Renal Renin of the Rat

Solomon¹,

Iaina²,

Eliahou³

et al. 1977

Neonatology

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Plasma renin activity (PRA) of infant rats is high until some time between the 3rd and 4th week after birth. Mothers, however, return PRA to normal by 2 weeks post partum. The rate of disappearance of endogenous PRA of nephrectomized rats is slower in those animals having high PRA than in mature rats. Disappearance curves of endogenous PRA of mothers post partum is also the same as that of normal mature females. Part of the high PRA of the neonate can thereby be related to the lower rate of destruction. Total kidney renin content increases with age. Renal renin activity (RRA) is low only during the 1st postnatal week when expressed in terms of whole kidney weight and compared to later postnatal times. Although there are some slight differences in the means in older animals, none are statistically significant.

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Possible Determinants of Plasma Renin Activity in Infant Rats

Cited by 9 publications

References 9 publications

Sodium, Potassium and Age: Possible Determinants of Plasma Renin Activity and Aldosterone During Childhood (Age 4–16)

Sodium, Potassium and Age: Possible Determinants of Plasma Renin Activity and Aldosterone During Childhood (Age 4–16)

Regulation of Plasma Renin in Developing Piglets

Postnatal Changes in Plasma and Renal Renin of the Rat

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