Possible Central Effect of Dantrolene Sodium in Neuroleptic Malignant Syndrome

Yamawaki, Shigeto; Yanagawa, Kosaku; Morio, Michio; Mori, Kenjiro

doi:10.1097/00004714-198612000-00020

Cited by 20 publications

(11 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CCBs might be considered in the presence of physical conditions in which other medications would be more dangerous (e.g., pregnancy) or in which a CCB might be helpful (e.g.. hypertension). Additional physical disorders common in affectively ill patients that may be helped by CCBs are listed in table 5 [50][51][52][53][54][55][56][57][58],…”

Section: Discussionmentioning

confidence: 99%

Calcium Antagonists in Manic-Depressive Illness

Dubovsky

1993

Neuropsychobiology

View full text Add to dashboard Cite

Increased free intracellular calcium ion concentration ([Ca²⁺]_¡) has been found in lymphocytes and blood platelets of patients with bipolar affective disorders when they are acutely ill, but not after recovery. Because lithium alters intracellular calcium ion dynamics and lowers platelet [Ca²⁺]_¡ in affectively ill patients but not controls, drugs whose primary action is to modulate [Ca²⁺]_¡ in hyperactive cells have been used as antimanic agents. The best studied of these is verapamil, a calcium channel blocking agent (CCB) that appears most effective for lithium-responsive patients. Because they interact with different central CCB receptors, second-generation CCBs may have a different spectrum of action. CCBs are usually well tolerated and may be useful for a number of other psychiatric, neurological and medical conditions.

show abstract

Section: Discussionmentioning

confidence: 99%

Calcium Antagonists in Manic-Depressive Illness

Dubovsky

1993

Neuropsychobiology

View full text Add to dashboard Cite

show abstract

“…Dantrolene has been reported to exhibit a direct effect on the CNS (Yamawaki and Yanagawa, 1986) and to affect the intracellular Ca 2+ mobilization of neuronal cells (Desmedt and Hainaut, 1979;Kato and Yamawaki, 1989;Frandsen and Schousboe, 1991;Hayashi et al, 1994). Clinically, dantrolene induces adverse central effects such as somnolence and depression (Britt, 1984).…”

Section: Introductionmentioning

confidence: 99%

Effect of dantrolene on KCl- or NMDA-induced intracellular Ca2+ changes and spontaneous Ca2+ oscillation in cultured rat frontal cortical neurons

Hayashi

Kagaya

Takebayashi

et al. 1997

J. Neural Transmission

View full text Add to dashboard Cite

Dantrolene has been known to affect intracellular Ca2+ concentration ([Ca2+]i) by inhibiting Ca2+ release from intracellular stores in cultured neurons. We were interested in examining this property of dantrolene in influencing the [Ca2+]i affected by the NMDA receptor ligands, KCl, L-type Ca2+ channel blocker nifedipine, and two other intracellular Ca2(+)-mobilizing agents caffeine and bradykinin. Effect of dantrolene on the spontaneous oscillation of [Ca2+]i was also examined. Dantrolene in microM concentrations dose-dependently inhibited the increase in [Ca2+]i elicited by NMDA and KCl. AP-5, MK-801 (NMDA antagonists), and nifedipine respectively reduced the NMDA and KCl-induced increase in [Ca2+]i. Dantrolene, added to the buffer solution together with the antagonists or nifedipine, caused a further reduction in [Ca2+]i to a degree similar to that seen with dantrolene alone inhibiting the increase in [Ca2+]i caused by NMDA or KCl. At 30 microM, dantrolene partially inhibited caffeine-induced increase in [Ca2+]i whereas it has no effect on the bradykinin-induced change in [Ca2+]i. The spontaneous oscillation of [Ca2+]i in frontal cortical neurons was reduced both in amplitude and in base line concentration in the presence of 10 microM dantrolene. Our results indicate that dantrolene's mobilizing effects on intracellular Ca2+ stores operate independently from the influxed Ca2+ and that a component of the apparent increase in [Ca2+]i elicited by NMDA or KCl represents a dantrolene-sensitive Ca2+ release from intracellular stores. Results also suggest that dantrolene does not affect the IP3-gated release of intracellular Ca2+ and that the spontaneous Ca2+ oscillation is, at least partially, under the control of Ca2+ mobilization from internal stores.

show abstract

“…Improvement was defined as marked reduction in the 4 main symptoms (rigidity, fever, autonomic instability, and altered consciousness) with CPK normalization. Gurrerra 17 describes the pathophysiology cascade of NMS, which includes sympathoadrenal hyperactivity and dysregulation, and Yamawaki et al 18 In the present case, NMS improved relatively quickly and completely disappeared, although the serum level of risperidone active moiety was maintained at a steady-state level. In our patient, the duration was 10 days, which is generally shorter than for NMS associated with oral risperidone.…”

Section: Discussionmentioning

confidence: 47%