Positron Emission Tomography of Brain β-Amyloid and Tau Levels in Adults With Down Syndrome

Cognitive functioning in relation to brain amyloid-β in healthy adults with Down syndrome

“…However, only visual episodic memory (Rivermead Picture Recognition) remained at a significant level when chronological age was included in models. Chronological age was associated with neocortical PiB retention, which was expected and is in line with previous work (Jack et al, 2008;Wolk et al, 2009;Rowe et al, 2010;Nelson et al, 2011). Adults with Down syndrome who were PiB-positive were, on average, 10 years older than those in the PiB-negative group.…”

“…In the present study, we examined neocortial PiB standardized uptake value ratio in six regions of interest, which is consistent with previous work (Wolk et al, 2009;Rowe et al, 2010;Nelson et al, 2011). In the study sample, amyloid-b deposition first occurred in the striatal region.…”

Cognitive functioning in relation to brain amyloid-β in healthy adults with Down syndrome

“…However, only visual episodic memory (Rivermead Picture Recognition) remained at a significant level when chronological age was included in models. Chronological age was associated with neocortical PiB retention, which was expected and is in line with previous work (Jack et al, 2008;Wolk et al, 2009;Rowe et al, 2010;Nelson et al, 2011). Adults with Down syndrome who were PiB-positive were, on average, 10 years older than those in the PiB-negative group.…”

“…In the present study, we examined neocortial PiB standardized uptake value ratio in six regions of interest, which is consistent with previous work (Wolk et al, 2009;Rowe et al, 2010;Nelson et al, 2011). In the study sample, amyloid-b deposition first occurred in the striatal region.…”

Establishing diagnostic thresholds for Alzheimer's disease in adults with Down syndrome: the Cambridge Examination for Mental Disorders of Older People with Down's Syndrome and Others with Intellectual Disabilities (CAMDEX-DS)

“… 9 Additionally, the correspondence of CAMDEX-DS total score and Aβ binding was most evident in frontotemporal regions, consistent with previous studies tracking the amyloid pathology related to dementia diagnostic status in adults with Down syndrome. 6 , 10 Keator et al 11 identified that Aβ binding particularly in the middle and superior orbitofrontal and the superior temporal lobes were associated with dementia status, mirroring our results showing strongest correlations with CAMDEX-DS total score in these regions. However, in a more recent study comparing mild cognitive impairment in people with Down syndrome (analogous to prodromal Alzheimer's disease in this study) with cognitively stable participants, Keator et al 12 found only small differences in orbitofrontal Aβ binding.…”

Down syndrome, beta-amyloid and neuroimaging

“…Similar results have been reported for other Aβ ligands including Florbetapir [115–117] and 2-(1-[118]ethylidene) malononitrile ([(18)F]FDDNP) [118]. FDDNP also binds to tau and it is not possible to distinguish Aβ plaques from neurofibrillary tangles.…”

Cognitive functioning in relation to brain amyloid-β in healthy adults with Down syndrome

“…However, only visual episodic memory (Rivermead Picture Recognition) remained at a significant level when chronological age was included in models. Chronological age was associated with neocortical PiB retention, which was expected and is in line with previous work (Jack et al, 2008;Wolk et al, 2009;Rowe et al, 2010;Nelson et al, 2011). Adults with Down syndrome who were PiB-positive were, on average, 10 years older than those in the PiB-negative group.…”

“…In the present study, we examined neocortial PiB standardized uptake value ratio in six regions of interest, which is consistent with previous work (Wolk et al, 2009;Rowe et al, 2010;Nelson et al, 2011). In the study sample, amyloid-b deposition first occurred in the striatal region.…”

Establishing diagnostic thresholds for Alzheimer's disease in adults with Down syndrome: the Cambridge Examination for Mental Disorders of Older People with Down's Syndrome and Others with Intellectual Disabilities (CAMDEX-DS)

“… 9 Additionally, the correspondence of CAMDEX-DS total score and Aβ binding was most evident in frontotemporal regions, consistent with previous studies tracking the amyloid pathology related to dementia diagnostic status in adults with Down syndrome. 6 , 10 Keator et al 11 identified that Aβ binding particularly in the middle and superior orbitofrontal and the superior temporal lobes were associated with dementia status, mirroring our results showing strongest correlations with CAMDEX-DS total score in these regions. However, in a more recent study comparing mild cognitive impairment in people with Down syndrome (analogous to prodromal Alzheimer's disease in this study) with cognitively stable participants, Keator et al 12 found only small differences in orbitofrontal Aβ binding.…”

Down syndrome, beta-amyloid and neuroimaging

“…Similar results have been reported for other Aβ ligands including Florbetapir [115–117] and 2-(1-[118]ethylidene) malononitrile ([(18)F]FDDNP) [118]. FDDNP also binds to tau and it is not possible to distinguish Aβ plaques from neurofibrillary tangles.…”

Cognitive functioning in relation to brain amyloid-β in healthy adults with Down syndrome

“…However, only visual episodic memory (Rivermead Picture Recognition) remained at a significant level when chronological age was included in models. Chronological age was associated with neocortical PiB retention, which was expected and is in line with previous work (Jack et al, 2008;Wolk et al, 2009;Rowe et al, 2010;Nelson et al, 2011). Adults with Down syndrome who were PiB-positive were, on average, 10 years older than those in the PiB-negative group.…”

“…In the present study, we examined neocortial PiB standardized uptake value ratio in six regions of interest, which is consistent with previous work (Wolk et al, 2009;Rowe et al, 2010;Nelson et al, 2011). In the study sample, amyloid-b deposition first occurred in the striatal region.…”

Establishing diagnostic thresholds for Alzheimer's disease in adults with Down syndrome: the Cambridge Examination for Mental Disorders of Older People with Down's Syndrome and Others with Intellectual Disabilities (CAMDEX-DS)

“… 9 Additionally, the correspondence of CAMDEX-DS total score and Aβ binding was most evident in frontotemporal regions, consistent with previous studies tracking the amyloid pathology related to dementia diagnostic status in adults with Down syndrome. 6 , 10 Keator et al 11 identified that Aβ binding particularly in the middle and superior orbitofrontal and the superior temporal lobes were associated with dementia status, mirroring our results showing strongest correlations with CAMDEX-DS total score in these regions. However, in a more recent study comparing mild cognitive impairment in people with Down syndrome (analogous to prodromal Alzheimer's disease in this study) with cognitively stable participants, Keator et al 12 found only small differences in orbitofrontal Aβ binding.…”

Down syndrome, beta-amyloid and neuroimaging

“…Similar results have been reported for other Aβ ligands including Florbetapir [115–117] and 2-(1-[118]ethylidene) malononitrile ([(18)F]FDDNP) [118]. FDDNP also binds to tau and it is not possible to distinguish Aβ plaques from neurofibrillary tangles.…”