Positron Emission Tomography in Creutzfeldt-Jakob Disease

Glucose metabolism in sporadic Creutzfeldt–Jakob disease: a statistical parametric mapping analysis of 18F‐FDG PET

“…One of the most interesting finding was that the basal ganglia as well as the thalamus, two areas commonly involved in sCJD (particularly the basal ganglia) in MRI studies [1,2,4,5], were unaffected in the context of metabolism. This result is compatible with a previous 18 F‐FDG PET group study based on a ROIs method that found the putamen and thalamus were less affected in nine patients [16] and with most case reports, which did not show involvement of deep grey matter [6–9,11–14]. Another PET study showed that only one of total eight patients with sCJD demonstrated involvement of the cerebellum, which is also be compatible with our results [15].…”

Glucose metabolism in sporadic Creutzfeldt–Jakob disease: a statistical parametric mapping analysis of 18F‐FDG PET

“…One of the most interesting finding was that the basal ganglia as well as the thalamus, two areas commonly involved in sCJD (particularly the basal ganglia) in MRI studies [1,2,4,5], were unaffected in the context of metabolism. This result is compatible with a previous 18 F‐FDG PET group study based on a ROIs method that found the putamen and thalamus were less affected in nine patients [16] and with most case reports, which did not show involvement of deep grey matter [6–9,11–14]. Another PET study showed that only one of total eight patients with sCJD demonstrated involvement of the cerebellum, which is also be compatible with our results [15].…”

Autopsy as Gold Standard in FDG-PET Studies in Dementia

“…The pathological diagnoses of the case reports are diverse. There are eight cases of prion diseases [14][15][16][17][18][19][20][21] , five isolated AD [22][23][24][25][26] , four frontotemporal lobar degeneration (FTLD) [27][28][29][30] , four pure diffuse Lewy body disease (DLBD) [31][32][33][34] , two mixed AD and DLBD [35][36] , two progressive supranuclear palsy [37][38] and one Parkinson's disease 39 . In contrast, most of the case series refer to patients with a pathological diagnosis of AD [40][41][42][43][44][45][46][47] or to a group of patients presenting either AD or another diagnosis such as DLBD 48 or FTLD 49 .…”

Positron emission tomography with [ 18 F]FDG in the diagnosis of Creutzfeldt-Jakob disease (CJD)

“…Weighted kappa was calculated for interrater's agreement [6,10]. Additionally four cases from the literature with well documented clinical and PET investigations were reviewed and data were compared with our findings [12,16,23,45]. The agreement of the two raters was strong with a weighted κ of 0,98.…”

“…The mean activity of the [ 18 F]FDG was 308 MBq (range 198-370 MBq). Mean uptake time was about 30 minutes (range[19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] and acquisition time varied between 15 and 20 minutes. After transmission correction static frames were reconstructed.…”

Glucose metabolism in sporadic Creutzfeldt–Jakob disease: a statistical parametric mapping analysis of 18F‐FDG PET

“…One of the most interesting finding was that the basal ganglia as well as the thalamus, two areas commonly involved in sCJD (particularly the basal ganglia) in MRI studies [1,2,4,5], were unaffected in the context of metabolism. This result is compatible with a previous 18 F‐FDG PET group study based on a ROIs method that found the putamen and thalamus were less affected in nine patients [16] and with most case reports, which did not show involvement of deep grey matter [6–9,11–14]. Another PET study showed that only one of total eight patients with sCJD demonstrated involvement of the cerebellum, which is also be compatible with our results [15].…”

Autopsy as Gold Standard in FDG-PET Studies in Dementia

“…The pathological diagnoses of the case reports are diverse. There are eight cases of prion diseases [14][15][16][17][18][19][20][21] , five isolated AD [22][23][24][25][26] , four frontotemporal lobar degeneration (FTLD) [27][28][29][30] , four pure diffuse Lewy body disease (DLBD) [31][32][33][34] , two mixed AD and DLBD [35][36] , two progressive supranuclear palsy [37][38] and one Parkinson's disease 39 . In contrast, most of the case series refer to patients with a pathological diagnosis of AD [40][41][42][43][44][45][46][47] or to a group of patients presenting either AD or another diagnosis such as DLBD 48 or FTLD 49 .…”

Positron emission tomography with [ 18 F]FDG in the diagnosis of Creutzfeldt-Jakob disease (CJD)

“…Weighted kappa was calculated for interrater's agreement [6,10]. Additionally four cases from the literature with well documented clinical and PET investigations were reviewed and data were compared with our findings [12,16,23,45]. The agreement of the two raters was strong with a weighted κ of 0,98.…”

“…The mean activity of the [ 18 F]FDG was 308 MBq (range 198-370 MBq). Mean uptake time was about 30 minutes (range[19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] and acquisition time varied between 15 and 20 minutes. After transmission correction static frames were reconstructed.…”

Glucose metabolism in sporadic Creutzfeldt–Jakob disease: a statistical parametric mapping analysis of 18F‐FDG PET

“…One of the most interesting finding was that the basal ganglia as well as the thalamus, two areas commonly involved in sCJD (particularly the basal ganglia) in MRI studies [1,2,4,5], were unaffected in the context of metabolism. This result is compatible with a previous 18 F‐FDG PET group study based on a ROIs method that found the putamen and thalamus were less affected in nine patients [16] and with most case reports, which did not show involvement of deep grey matter [6–9,11–14]. Another PET study showed that only one of total eight patients with sCJD demonstrated involvement of the cerebellum, which is also be compatible with our results [15].…”

Autopsy as Gold Standard in FDG-PET Studies in Dementia

“…The pathological diagnoses of the case reports are diverse. There are eight cases of prion diseases [14][15][16][17][18][19][20][21] , five isolated AD [22][23][24][25][26] , four frontotemporal lobar degeneration (FTLD) [27][28][29][30] , four pure diffuse Lewy body disease (DLBD) [31][32][33][34] , two mixed AD and DLBD [35][36] , two progressive supranuclear palsy [37][38] and one Parkinson's disease 39 . In contrast, most of the case series refer to patients with a pathological diagnosis of AD [40][41][42][43][44][45][46][47] or to a group of patients presenting either AD or another diagnosis such as DLBD 48 or FTLD 49 .…”

Positron emission tomography with [ 18 F]FDG in the diagnosis of Creutzfeldt-Jakob disease (CJD)

“…Weighted kappa was calculated for interrater's agreement [6,10]. Additionally four cases from the literature with well documented clinical and PET investigations were reviewed and data were compared with our findings [12,16,23,45]. The agreement of the two raters was strong with a weighted κ of 0,98.…”

“…The mean activity of the [ 18 F]FDG was 308 MBq (range 198-370 MBq). Mean uptake time was about 30 minutes (range[19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37] and acquisition time varied between 15 and 20 minutes. After transmission correction static frames were reconstructed.…”