Positive Weil‐Felix Reactions in a Case of Rickettsialpox

Jacobson, Jeffrey M.; Desmond, Edward; Kornblee, Leonard; Hirschman, Shalom Z.

doi:10.1111/j.1365-4362.1989.tb04821.x

Cited by 9 publications

(3 citation statements)

References 6 publications

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“…7 Except for one reported case in which the serum of a 33-year-old man with rickettsialpox that showed a greater than fourfold increase in the titers of Proteus OX-2 and OX-19, the Weil-Felix test typically does not detect antibodies to R. Akari. 8 However, serum antibodies can be identified by complement fixation studies within 10 days of the start of generalized symptoms, with titers peaking after 3-4 weeks in untreated patients and after 6-8 weeks in patients treated with antibiotics. 3 The histopathology of the primary lesions, or eschars, shows extensive inflammation and necrosis of the dermis and subcutaneous tissue, while papulovesicles show superficial edema and frank separation of the epidermal-dermal junction, which forms a subepidermal vesicle.…”

Section: Diagnosismentioning

confidence: 99%

Rickettsial Infections Around the World, Part 2: Rickettsialpox, the Typhus Group, and Bioterrorism

Huang

Pang

et al. 2005

J Cutan Med Surg

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Section: Diagnosismentioning

confidence: 99%

Rickettsial Infections Around the World, Part 2: Rickettsialpox, the Typhus Group, and Bioterrorism

Huang

Pang

et al. 2005

J Cutan Med Surg

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“…Except for one reported case in which the serum of a 33-year-old man with rickettsialpox that showed a greater than fourfold increase in the tit ers of Proteus OX-2 and OX-19, the Weil-Felix test typically does not detect antibodies to R. Akm-i. 8 However, serum antibodies can be identified by complement fixation studies within 10 days of the start of generalized symptoms, with titers peaking after 3-4 weeks in untreated patients and after 6-8 weeks in patients treated with antibiotics. 3 The histopathology of the primary lesions, or eschars, shows extensive inflammation and necrosis of the dermis and subcutaneous tissue , while papulovesicles show superficial edema and frank separation of the epidermal-dermal junction, which forms a subepidermal vesicle.…”

Section: Diagnosismentioning

confidence: 99%

Rickettsial Infections around the World, Part 2: Rickettsialpox, the Typhus Group, and Bioterrorism

Huang

Pang

et al. 2005

J Cutan Med Surg

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I n this second part of our review of rickettsial infections, we discuss rickettsialpox, the typhus group, and factors that make this disease class a possible agent of bioterrorism. Rickettsialpox Epidemiology (Table I) Rickettsialpox is caused by the organism Rickettsia akari, a small obligate intracellular bacteria with a cell wall similar to that of gram-negative bacteria. It has the same lipopolysaccharide antigens as others of the spotted fever rickettsial group.' The arthropod vector for rickettsialpox is Liponyssoides sanguineus, a bloodsucking mite that feeds on rodents.i The house mouse, Mus musculus, is the reservoir for rickettsialpox, and humans are infected only if mice or other preferred hosts are not accessible. R. akari is maintained by transovarial transmission in mites so human transmission is not essential for the life cycle. Clinical Manifestations The disease starts with a primary skin lesion at the site of inoculation by the mite and, after a usual incubation period of 9-14 days, progresses into a febrile illness, followed by a secondary papulovesicular eruption.' The systemic symptoms are self-limited, usually resolving in

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“…16 Since the 1960s, only single case reports and small case series have been published, and most of these cases have occurred in New York City. 1,9,11,15,[17][18][19] The largest of these series described 13 patients examined during a 10-year period.…”

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confidence: 99%

Increased Detection of Rickettsialpox in a New York City Hospital Following the Anthrax Outbreak of 2001

Koss

Carter²,

Grossman³

et al. 2003

Arch Dermatol

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Positive Weil‐Felix Reactions in a Case of Rickettsialpox

Cited by 9 publications

References 6 publications

Rickettsial Infections Around the World, Part 2: Rickettsialpox, the Typhus Group, and Bioterrorism

Rickettsial Infections Around the World, Part 2: Rickettsialpox, the Typhus Group, and Bioterrorism

Rickettsial Infections around the World, Part 2: Rickettsialpox, the Typhus Group, and Bioterrorism

Increased Detection of Rickettsialpox in a New York City Hospital Following the Anthrax Outbreak of 2001

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