Positive Symptoms of Schizophrenia: Response to Haloperidol and Remoxipride is Associated with Increased Alpha EEG Activity

Characterization of atypical antipsychotic drugs by a late decrease of striatal alpha1 spectral power in the electropharmacogram of freely moving rats

“…(1994) reported data suggesting a relationship between plasma levels and BPRS score after a single administration of haloperidol decanoate to schizophrenic patients monitored weekly for effects on the EEG with respect to temporal electrode T6. Increased α power after the administration of haloperidol and remoxipride in connection with clinical improvement has also been reported by Moore et al . (1997).…”

Do we have any solid evidence of clinical utility about the pathophysiology of schizophrenia?

“…There is also a strikingly consistent literature on the EEG and treatment response in schizophrenia, in which increased pre‐ and/or post‐treatment alpha‐wave EEG activity predicts response to antipsychotics in five out of the six studies we are aware of 143,144,145,146,147,148. There is enough replication here to justify further studies of PET and EEG of anti‐ psychotic drug response and to begin to evaluate this in terms of their potential clinical significance.…”

Characteristics of EEG activity during high altitude hypoxia and lowland reoxygenation

“…Alpha activity has been associated with inhibition, attention, long-range synchronization, and memory performance (Klimesch, 1999;Uhlhaas and Singer, 2013). Increases of alpha EEG activity were found in schizophrenia patient (Moore et al, 1997)…”