Positive Papular Phototests in Normal Subjects

Schorr, William F.

doi:10.1001/archderm.1963.01590170018003

Cited by 7 publications

(3 citation statements)

References 6 publications

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“…The explanation frequently offered for this wide range of positive results is the failure to standardize the technique: the light source, dose of light, frequency of exposure and location of test site are all variables which have not been controlled. An additional factor, one that has been reported (Schorr & Monash, 1963) but is rarely mentioned (and possibly not adequately appreciated), is the difficulty in distinguishing between a normal response with erythema and oedema, and an abnormal one with papules or plaques. For example, the normal response to repeated exposures of multiples of the MED to UV-B (MED,,) is an oedematous, fiery red test site.…”

Section: The Role Of Light Testing In Pmlementioning

confidence: 99%

The role of histopathology in polymorphous light eruption light testing

et al. 1981

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Summary Provocative light testing was performed in ten patients with polymorphous light eruption (Pmle) and in ten normal subjects to determine whether the histopathology of irradiated test sites could be used as an end point for a positive response. Three separate test sites on the lower back were irradiated (UV‐B) with a single exposure to i minimal erythema dose (MED), a single exposure to 5 x MED, or three consecutive daily exposures to 3 x MED. Biopsies of all test sites were coded and examined without knowing if the biopsy was from a normal subject or a patient with Pmle. In no case was a rash reproduced by light testing. A spectrum of histologic features were observed at the three test sites in both normal subjects and patients with Pmle with no significant differences noted between the two groups. It was concluded that the histology at these UV‐B irradiated test sites could not be used as an endpoint Pmle for testing. In establishing Pmle light testing techniques which rely on histology it is mandatory to include adequate numbers of normal controls.

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Section: The Role Of Light Testing In Pmlementioning

confidence: 99%

The role of histopathology in polymorphous light eruption light testing

et al. 1981

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“…By exposing a small skin area of a PMLE patient with multiples of the minimal erythema dose (MED) thc lcsions could be reproduced (6,7,11,18,25).…”

Section: Acra Dermt1101•ener (Stockho/111) 52mentioning

confidence: 99%

Treatment of polymorphous light eruptions with beta-carotene

Swanbeck¹,

Wennersten²

1972

Acta Derm Venereol

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“…- 32), ( 33), ( 42), ( 47), ( 49), ( 54), ( 63), ( 81), ( 84), ( 87), ( 95), ( 109), ( 110), ( 111), ( 112), ( 113), ( 114), ( 115), ( 127), ( 128), ( 129), ( 133), ( 138), ( 141), ( 142), ( 143), ( 144), ( 145), ( 158), ( 162), (193), (197), ( 204), ( 205), ( 207), (210) Στη θεραπεία της λεύκης χρησιμοποιούνται συνθετικές φουρανοκουμαρίνες διότι αυτές προάγουν την μελανογένεση στο ανθρώπινο δέρμα το οποίο εκτίθεται στην υπεριώδη ακτινοβολία.…”

Section: τα κυριώτερα φάρμακα συστηματικώς χορηγούμενα που προκαλούν φωτοτοξικές αντιδράσεις είναιunclassified

In vitro έλεγχος φαρμακευτικής φωτοευαισθησίας

Kefala¹,

Κεφάλα²

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Positive Papular Phototests in Normal Subjects

Cited by 7 publications

References 6 publications

The role of histopathology in polymorphous light eruption light testing

The role of histopathology in polymorphous light eruption light testing

Treatment of polymorphous light eruptions with beta-carotene

In vitro έλεγχος φαρμακευτικής φωτοευαισθησίας

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