Positive Feedback Loop of Long Noncoding RNA OASL-IT1 and Innate Immune Response Restricts the Replication of Zika Virus in Epithelial A549 Cells

Wang, Yi; Huo, Zhiting; Lin, Quanshi; Lin, Yuxia; Chen, Cancan; Huang, Yanxia; Huang, Chenghui; Zhang, Junsong; He, Jun; Liu, Chao; Zhang, Ping

doi:10.1159/000513606

Cited by 14 publications

(19 citation statements)

References 54 publications

(74 reference statements)

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“…Accumulating evidence supports the important role of host-encoded lncRNAs in regulating immune response [ 15–17 ]. Some of the recent examples include: lncRNA OASL-IT1 and interferon loop system that regulates antiviral defense against Zika Virus [ 18 ]; lncRNA NLRP3 promotes NLRP3-triggered inflammatory response in early acute lung injury by binding to miR-138-5p [ 19 ]; mRNA-lncRNA crosstalk is involved in immune regulation of carp macrophages [ 20 ]; lncRNA THUMPD3-AS1 is downregulated in osteoarthritis and when overexpressed, it promotes cell proliferation, reduces apoptosis and facilitates inflammatory response [ 19 ]. Besides, host-encoded lncRNAs have also been found to regulate viral infection.…”

Section: Introductionmentioning

confidence: 99%

Differential expression of long non-coding RNAs under Peste des petits ruminants virus (PPRV) infection in goats

et al. 2022

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Peste des petits ruminants (PPR) characterized by fever, sore mouth, conjunctivitis, gastroenteritis, and pneumonia, is an acute, highly contagious viral disease of sheep and goats. The role of long non-coding RNAs (lncRNAs) in PPRV infection has not been explored to date. In this study, the transcriptome profiles of virulent Peste des petits ruminants virus (PPRV) infected goat tissues – lung and spleen were analyzed to identify the role of lncRNAs in PPRV infection. A total of 13,928 lncRNA transcripts were identified, out of which 170 were known lncRNAs. Intergenic lncRNAs (7625) formed the major chunk of the novel lncRNA transcripts. Differential expression analysis revealed that 15 lncRNAs (11 downregulated and 4 upregulated) in the PPRV infected spleen samples and 16 lncRNAs (13 downregulated and 3 upregulated) in PPRV infected lung samples were differentially expressed as compared to control. The differentially expressed lncRNAs (DElncRNAs) possibly regulate various immunological processes related to natural killer cell activation, antigen processing and presentation, and B cell activity, by regulating the expression of mRNAs through the cis- or trans-regulatory mechanism. Functional enrichment analysis of differentially expressed mRNAs (DEmRNAs) revealed enrichment of immune pathways and biological processes in concordance with the pathways in which correlated lncRNA-neighboring genes were enriched. The results suggest that a coordinated immune response is raised in both lung and spleen tissues of the goat through mRNA-lncRNA crosstalk.

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Section: Introductionmentioning

confidence: 99%

Differential expression of long non-coding RNAs under Peste des petits ruminants virus (PPRV) infection in goats

et al. 2022

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“…LncRNA OASL-IT1 positively regulates IFN-I signaling (81). Silencing of its expression via knockout or knockdown impairs the phosphorylation modification of p38 of mitogenactivated protein kinases (MAPK), IRF3, and NF-kB p65 in response to ZIKA infection (82). The detail of its mechanism is still not understood.…”

Section: General Downstream Cascades For Ifn-i Transcription Activationmentioning

confidence: 99%

Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway

Wang

Liu

et al. 2022

Front. Immunol.

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The type-I interferon (IFN-I) signaling pathway plays pivot roles in defending against pathogen invasion. Exogenous ssRNA and dsRNA could be immunogenic. RNA-mediated IFN signaling is extensively studied in the field. The incorrect functioning of this pathway leads to either autoimmune diseases or suffering from microorganism invasion. From the discrimination of “self” and “non-self” molecules by receptors to the fine-tune modulations in downstream cascades, all steps are under the surveillance featured by complex feedbacks and regulators. Studies in recent years highlighted the emerging roles of long noncoding RNAs (lncRNAs) as a reservoir for signaling regulation. LncRNAs bind to targets through the structure and sequence, and thus the mechanisms of action can be complex and specific. Here, we summarized lncRNAs modulating the RNA-activated IFN-I signaling pathway according to the event order during the signaling. We hope this review help understand how lncRNAs are participating in the regulation of IFN-I signaling.

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“…This complex acts as a scaffold to promote and stabilize the interaction between TRIM25 and the activated RIG-I, and then strengthens TRIM25mediated K63-linked ubiquitination of RIG-I [133]. In epithelial A549 cells, researchers found that lncRNA OASL-IT1 promotes the phosphorylation of p38 MAPK, IRF3, and NF-κB p65, leading to the expression of IFN-β and two classic ISGs (MX1 and IFITM1) in a positive feedback manner during Zika virus (ZIKV) infection [134].…”

Section: Long Non-coding Rnas Promote Antiviral Innate Immune Responsementioning

confidence: 99%

A Novel Regulatory Player in the Innate Immune System: Long Non-Coding RNAs

Xie

Wei

2021

IJMS

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Long non-coding RNAs (lncRNAs) represent crucial transcriptional and post-transcriptional gene regulators during antimicrobial responses in the host innate immune system. Studies have shown that lncRNAs are expressed in a highly tissue- and cell-specific- manner and are involved in the differentiation and function of innate immune cells, as well as inflammatory and antiviral processes, through versatile molecular mechanisms. These lncRNAs function via the interactions with DNA, RNA, or protein in either cis or trans pattern, relying on their specific sequences or their transcriptions and processing. The dysregulation of lncRNA function is associated with various human non-infectious diseases, such as inflammatory bowel disease, cardiovascular diseases, and diabetes mellitus. Here, we provide an overview of the regulation and mechanisms of lncRNA function in the development and differentiation of innate immune cells, and during the activation or repression of innate immune responses. These elucidations might be beneficial for the development of therapeutic strategies targeting inflammatory and innate immune-mediated diseases.

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Positive Feedback Loop of Long Noncoding RNA OASL-IT1 and Innate Immune Response Restricts the Replication of Zika Virus in Epithelial A549 Cells

Cited by 14 publications

References 54 publications

Differential expression of long non-coding RNAs under Peste des petits ruminants virus (PPRV) infection in goats

Differential expression of long non-coding RNAs under Peste des petits ruminants virus (PPRV) infection in goats

Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway

A Novel Regulatory Player in the Innate Immune System: Long Non-Coding RNAs

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