Positive effect of wrapping poly caprolactone/polyethylene glycol fibrous films on the mechanical properties of 45S5 bioactive glass scaffolds

Abstract

45S5 bioactive glass (BG) scaffolds show great potential in bone tissue engineering due to their superior osteoinductivity and osteoconductivity. However, such scaffolds generally possess poor mechanical properties. Here, inspired by the reinforcing principle of confined concrete elements in civil engineering, poly caprolactone (PCL)/polyethylene glycol (PEG) film-wrapped 45S5 BG scaffolds were prepared by gluing highly porous foam-replicated BG scaffolds and electrospun PCL/PEG films together with a PCL layer. The results showed that the compressive strength of the PCL/PEG film-wrapped scaffolds was greatly improved, compared to that of unwrapped BG scaffolds. Moreover, the PCL/PEG film exhibited hydrophilicity, responsible for improved cell activity with respect to the hydrophobic PCL one. Thus, the present work introduces a convenient approach to improve the mechanical properties of highly porous bioceramic scaffolds, and is relevant for future robust scaffold design. K E Y W O R D S45S5 bioactive glass scaffold, bone tissue engineering, electrospinning, mechanical properties, poly caprolactone/polyethylene glycol film

Sintered S53P4 bioactive glass scaffolds have anti-inflammatory properties and stimulate osteogenesis in vitro

“…Indeed, it has been stated that BAG-S53P4 is the most frequently used BAG in clinical practice (Baino et al, 2018;Jones, 2013). In addition to promoting bone regeneration, BAG-S53P4 granules have antimicrobial properties that are based on the elevation of pH in the local microenvironment, due to the dissolution of the BAG (Stoor et al, 1998). Furthermore, the changes in osmotic pressure and ion concentrations have been reported to contribute to the antimicrobial properties Munukka et al, 2008;Zhang et al, 2010).…”

“…Indeed, it has been shown, in an in vivo rabbit model, that sintered BAG-S53P4 scaffolds not only stimulate early bone formation within the scaffold, but also induce a bioactive membrane with ample microvasculature and upregulated VEGF and BMP expression (Björkenheim et al, 2017;Björkenheim et al, 2019). In addition to giving the sintered BAG scaffold increased mechanical strength (Mantsos et al, 2009;Shi et al, 2018), PLGA coating is hypothesised to induce a stronger initial inflammatory reaction than BAG-S53P4 alone, with enhanced induced membrane formation and bone regeneration (Björkenheim et al, 2017;Björkenheim et al, 2019;Nicolete et al, 2011). This concept of polymer coated BAG scaffolds is not new; one of the first BAG scaffolds with RT-qPCR reverse transcriptase quantitative polymerase chain reaction RUNX2 runt-related transcription factor 2 SEM scanning electron microscopy SFM serum-free medium TNFα tumour necrosis factor α VEGF vascular endothelial growth factor www.ecmjournal.org polymer coating was described by Chen et al in 2006 (Chen andBoccaccini, 2006).…”

Electrospun PEO/PEG fibers as potential flexible phase change materials for thermal energy regulation

“…PEG is also commonly used as a plasticizer [50][51][52] given its high compatibility with different polymers, good water solubility and good processibility. It is frequently incorporated into PLA, [53,54] cellulose acetate, [36,55,56] polycaprolactone [57,58] etc. fibrous support matrix, especially in the biomedical field.…”

Dissolution of Amorphous S53P4 Glass Scaffolds in Dynamic In Vitro Conditions

“…The different techniques allow different pore structures, but they cannot overcome the inherent brittleness of glasses. In order to improve the mechanical properties, there has been a growing interest in using polymers as reinforcement materials [10,11,27,33]. The bioactivity and antibacterial effects of BAGs can also be utilized by applying BAGs as coatings, for which the modern techniques range from laser cladding to electrochemical deposition [34][35][36][37].…”