Positive associations of bone mineral density with body mass index, physical activity, and blood triglyceride level in men over 70 years old: a TCVGHAGE study

Tang, Yih-Jing; Sheu, Wayne Huey‐Herng; Liu, Pi-Haw; Lee, Wen‐Jane; Chen, Ying‐Tsung

doi:10.1007/s00774-006-0727-7

Cited by 36 publications

(22 citation statements)

References 34 publications

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“…Conversely, other studies have shown positive associations between BMD of various skeletal sites and lower extremity PP measures [41, 77, 78]. Results of the study in 368 older men aged 78.8 ± 4.1 years living in a veterans' home in Taiwan [78] found that the calcaneus bone mass measured by Soundscan (quantitative ultrasound) expressed as broadband ultrasound attenuation was positively correlated with walking speed measured by a 6-minute walking distance.…”

Section: Resultsmentioning

confidence: 96%

Relationship of Physical Performance with Body Composition and Bone Mineral Density in Individuals over 60 Years of Age: A Systematic Review

Shin

Panton

Dutton

et al. 2011

Journal of Aging Research

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The purpose of this review was to examine the relationship between physical performance and body composition measurements, including fat/muscle mass and bone mineral density (BMD) in individuals ≥60 years of age. Various measurements used to assess body composition, BMD, and physical performance (PP) were discussed as well. Medline/PubMed, CINAHL, and SCIE were used to identify articles. After limiting the search for age and kind of physical performance measures, 33 articles were evaluated. Higher fat mass was associated with poorer physical performance while higher muscle mass was a predictor of better physical performance, especially in the lower extremities. Additionally, evidence showed that higher muscle fat infiltration was a determinant of poorer physical performance. BMD was shown to be a good predictor of physical performance although the relationship was stronger in women than in men. Developing standardized methods for PP measurements could help in further investigation and conclusions of its relationship with body composition.

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Section: Resultsmentioning

confidence: 96%

Relationship of Physical Performance with Body Composition and Bone Mineral Density in Individuals over 60 Years of Age: A Systematic Review

Shin

Panton

Dutton

et al. 2011

Journal of Aging Research

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“…Although relevant data about the relationship between osteocalcin and lipid profile are scanty, there is increasing evidence showing a connection between lipids and bone metabolism in recent years. A number of studies focusing on the association between lipid profile and bone mass density (BMD) suggested that TG was positively associated with BMD and inversely associated with the presence of vertebral fractures (22)(23)(24). Adami et al also found reduced bone mass to be associated with a favorable lipid profile in healthy men (25).…”

Section: Discussionmentioning

confidence: 99%

Serum osteocalcin concentrations in relation to glucose and lipid metabolism in Chinese individuals

Zhou¹,

Ma²,

Li³

et al. 2009

European Journal of Endocrinology

176

128

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Objectives: Osteocalcin, a bone-derived protein, has recently been reported to affect energy metabolism. We investigated the relationship between serum osteocalcin and parameters of adiposity, glucose tolerance, and lipid profile in Chinese subjects. Methods: Serum osteocalcin was measured by electrochemiluminescence immunoassay in 254 men (128 with newly diagnosed type 2 diabetes mellitus (T2DM) and 126 with normal glucose tolerance (NGT)), 66 premenopausal women (33 with T2DM and 33 with NGT) as well as 180 postmenopausal women (92 with T2DM and 88 with NGT). Their associations with parameters of adiposity, glucose tolerance, and lipid profile were examined. Results: Serum osteocalcin concentrations in diabetic patients were significantly lower than those in NGT subjects after adjusted for age, gender, and body mass index (PZ0.003). Postmenopausal women had higher osteocalcin concentrations than premenopausal women and men (both P!0.001). Multiple stepwise regression analysis showed that age, %fat, high-density lipoprotein cholesterol, fasting plasma glucose, and fasting serum insulin were independently associated with osteocalcin in men (P!0.05). Age and HbA1c were independently correlated with osteocalcin in postmenopausal women. Besides age and HbA1c, serum triglyceride was also an independent factor influencing osteocalcin in premenopausal women. In addition, osteocalcin was also positively associated with homeostasis model assessment of b-cell function. Furthermore, multiple logistic regression analysis demonstrated that osteocalcin was independently associated with T2DM. Conclusions: Serum osteocalcin was closely associated with not only fat and glucose metabolism but also with lipid metabolism.

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“…(36)(37)(38) Unlike our data, TG level correlated positively with hip BMD and broadband ultrasound attenuation, whereas HDL-cholesterol level was correlated negatively with hip BMD in men. (39)(40)(41) There are other possible causes of low BMD in men with MetS. Men with MetS have lower levels of testosterone.…”

Section: Discussionmentioning

confidence: 99%

Men with metabolic syndrome have lower bone mineral density but lower fracture risk—the MINOS study

Szulc

Varennes

Delmas

et al. 2010

Journal of Bone and Mineral Research

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Data on the association of the metabolic syndrome (MetS) with bone mineral density (BMD) and fracture risk in men are inconsistent. We studied the association between MetS and bone status in 762 older men followed up for 10 years. After adjustment for age, body mass index, height, physical activity, smoking, alcohol intake, and serum 25-hydroxycholecalciferol D and 17b-estradiol levels, men with MetS had lower BMD at the hip, whole body, and distal forearm (2.2% to 3.2%, 0.24 to 0.27 SD, p < .05 to .005). This difference was related to abdominal obesity (assessed by waist circumference, waist-hip ratio, or central fat mass) but not other MetS components. Men with MetS had lower bone mineral content (3.1% to 4.5%, 0.22 to 0.29 SD, p < .05 to 0.001), whereas differences in bone size were milder. Men with MetS had a lower incidence of vertebral and peripheral fractures (6.7% versus 12.0%, p < .05). After adjustment for confounders, MetS was associated with a lower fracture incidence [odds ratio (OR) ¼ 0.33, 95% confidence interval (CI) 0.15-0.76, p < .01]. Among the MetS components, hypertriglyceridemia was most predictive of the lower fracture risk (OR ¼ 0.25, 95%CI 0.10-0.62, p < .005). Lower fracture risk in men with MetS cannot be explained by differences in bone size, rate of bone turnover rate and bone loss, or history of falls or fractures. Thus older men with MetS have a lower BMD related to the abdominal obesity and a lower risk of fracture related to hypertriglyceridemia. MetS probably is not a meaningful concept in the context of bone metabolism. Analysis of its association with bone-related variables may obscure the pathophysiologic links of its components with bone status. ß

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Positive associations of bone mineral density with body mass index, physical activity, and blood triglyceride level in men over 70 years old: a TCVGHAGE study

Cited by 36 publications

References 34 publications

Relationship of Physical Performance with Body Composition and Bone Mineral Density in Individuals over 60 Years of Age: A Systematic Review

Relationship of Physical Performance with Body Composition and Bone Mineral Density in Individuals over 60 Years of Age: A Systematic Review

Serum osteocalcin concentrations in relation to glucose and lipid metabolism in Chinese individuals

Men with metabolic syndrome have lower bone mineral density but lower fracture risk—the MINOS study

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