Positive association between high‐sensitivity C‐reactive protein and incidence of type 2 diabetes mellitus in Japanese workers: 6‐year follow‐up

Wang, Chaochen; Yatsuya, Hiroshi; Koji, Takehiko; Uemura, Mayu; Li, Yuanying; Wada, Keiko; Yamashita, Kentaro; Kawaguchi, Leo; Toyoshima, Hideaki; Aoyama, Atsuko

doi:10.1002/dmrr.2406

Cited by 30 publications

(21 citation statements)

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“…11 A recent study of more than 4,000 subjects followed for six years revealed that elevated hs-CRP was associated with type 2 diabetes. 12 Another study with a follow-up of 11 years also demonstrated the same association of hs-CRP with diabetes. 13 As expected, patients with lower glycosylated hemoglobin (A1C) levels were found to have signifi cantly lower hs-CRP levels.…”

Section: S C I E N T I F I C I N V E S T I G a T I O N Smentioning

confidence: 72%

Short Duration of Sleep Is Associated with Elevated High-Sensitivity C-Reactive Protein Level in Taiwanese Adults: A Cross-Sectional Study

Chiang¹

2014

Journal of Clinical Sleep Medicine

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Background: Elevated plasma levels of high-sensitivity C-reactive protein (hs-CRP) have been associated with increased adverse health outcomes. The aim of this study was to investigate the association of sleep duration with risk of elevated hs-CRP levels in Taiwanese adults. Methods: We examined the association between sleep duration and hs-CRP in 353 healthy adults recruited from the physical examination center at a regional hospital in southern Taiwan. Elevated hs-CRP was defi ned as a plasma level ≥ 0.20 mg/dL. Short sleep duration was defi ned as ≤ 5.5 h per day. Multiple logistic regression analysis was used to assess the association of short duration of sleep with elevated hs-CRP levels. Results: In this study, short duration of sleep (odds ratio [OR] = 2.20; 95% confi dence interval [CI]: 1.11-4.30), aged 70 years or older (OR = 4.58; 95% CI: 1.70-12.66), menopause (OR = 2.81; 95% CI: 1.52-5.3), higher heart rate (OR = 1.38; 95% CI: 1.10-1.75), higher body mass index (OR = 1.20; 95% CI: 1.09-1.34), higher white blood cell count (OR = 1.38; 95% CI: 1.14-1.66), and higher uric acid level (OR = 1.31; 95% CI: 1.06-1.63) were signifi cantly associated with an increased risk of elevated hs-CRP levels. Conclusions: In this study of healthy Taiwanese adults, short duration of sleep was signifi cantly associated with elevated hs-CRP levels. Activation of pro-infl ammatory pathways might represent a mechanism by which short sleep duration affects health. Keywords: sleep duration, C-reactive protein, high-sensitivity CRP, hs-CRP Citation: Chiang JK. Short duration of sleep is associated with elevated high-sensitivity C-reactive protein level in Taiwanese adults: a cross-sectional study. J Clin Sleep Med 2014;10(7):743-749.http://dx.doi.org/10.5664/jcsm.3862 S C I E N T I F I C I N V E S T I G A T I O N SC -reactive protein is secreted by the liver in response to acute infl ammation and infection.1 The high-sensitivity C-reactive protein (hs-CRP) assay has low detection limits, and good performance for apparently healthy subjects.2 Elevated hs-CRP levels have been associated with infl ammation, aging, cancer, adverse outcomes of angina pectoris, coronary artery disease, adverse outcomes of chronic obstructive pulmonary disease, stroke, and increased risk of mortality. [3][4][5][6][7][8][9][10] In addition, elevated hs-CRP has been shown to be a stronger predictor of cardiovascular disease than low-density lipoprotein cholesterol.11 A recent study of more than 4,000 subjects followed for six years revealed that elevated hs-CRP was associated with type 2 diabetes. 12Another study with a follow-up of 11 years also demonstrated the same association of hs-CRP with diabetes.13 As expected, patients with lower glycosylated hemoglobin (A1C) levels were found to have signifi cantly lower hs-CRP levels.14 In recent years it has been shown that sleep duration might affect health in a number of ways, such as its associations with insulin resistance, diabetes, hyperleptinemia, heart disease, and mortality.15-17 Specifi cally, sho...

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Section: S C I E N T I F I C I N V E S T I G a T I O N Smentioning

confidence: 72%

Short Duration of Sleep Is Associated with Elevated High-Sensitivity C-Reactive Protein Level in Taiwanese Adults: A Cross-Sectional Study

Chiang¹

2014

Journal of Clinical Sleep Medicine

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“…Increasing evidence shows that T2DM is a low-grade inflammatory disease1. In patients with T2DM, serum levels of pro-inflammatory cytokines such as interleukin-1 beta (IL-1β), interleukin-6 (IL-6), and CRP (C-reactive protein) are elevated and have been widely used as a biomarker of T2DM1234. This is particularly important in those with DN56, suggesting a close relationship between inflammation and T2DM/T2DN.…”

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confidence: 99%

C-Reactive Protein Promotes Diabetic Kidney Disease in db/db Mice via the CD32b-Smad3-mTOR signaling Pathway

You

Huang

Chen

et al. 2016

Sci Rep

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C-reactive protein (CRP) is associated with progressive diabetic nephropathy in patients with type-2 diabetes (T2DN). However, role of CRP in T2DN remains unclear. We report here that CRP is pathogenic in T2DN in db/db mice that express human CRP (CRPtg-db/db). Compared to the littermate db/db mice, CRPtg-db/db developed more severe T2DN, showing higher levels of fasting blood glucose and microalbuminuria and more progressive renal inflammation and fibrosis. Enhanced T2DN in CRPtg-db/db mice were associated with over-activation of CRP-CD32b, NF-κB, TGF-β/Smad3, and mTOR signaling. Further studies in vitro defined that CRP activated Smad3 directly at 15 mins via the CD32b- ERK/p38 MAP kinase crosstalk pathway and indirectly at 24 hours through a TGF-β1-dependent mechanism. Importantly, CRP also activated mTOR signaling at 30 mins via a Smad3-dependent mechanism as Smad3 bound mTOR physically and CRP-induced mTOR signaling was abolished by a neutralizing CD32b antibody and a specific Smad3 inhibitor. Finally, we also found that CRP induced renal fibrosis through a CD32b-Smad3-mTOR pathway because blocking mTOR signaling with rapamycin inhibited CRP-induced CTGF and collagen I expression. Thus, CRP is pathogenic in T2DN. CRP may promote CD32b- NF-κB signaling to mediate renal inflammation; whereas, CRP may enhance renal fibrosis in T2DN via CD32b-Smad3-mTOR signaling.

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“…The mechanisms for independent and synergistic effects of passive smoking and obesity are not known. Cigarette smoke and environmental pollutants induce inflammatory responses, as does obesity‐induced insulin resistance . However, the specific inflammatory markers associated with smoking and insulin resistance may differ, as well as the tissues affected by inflammation.…”

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confidence: 99%

Passive smoking as an independent risk factor for gestational diabetes that synergizes with prepregnancy obesity in urban Chinese women

Loeken

2017

Diabetes Metabolism Res

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There are high-priority public health and legislative efforts around the world to reduce smoking and to reduce the spaces where smoking is allowable. These efforts are aimed at minimizing not only the adverse health effects of active smoking but also the adverse health effects of passive cigarette smoke exposure. While many cultures and societies make protection of a pregnant woman and her about-to-be-born-newborn a priority, the importance of protecting them from passive smoking that is prevalent in many modern societies has not been reported. The article by Leng et al, “Passive smoking increased risk of gestational diabetes mellitus independently and synergistically with prepregnancy obesity in Tianjin, China,” newly published in Diabetes Metabolism Research and Reviews, provides evidence that passive smoke inhalation during pregnancy makes gestational diabetes more likely, bringing with it negative health consequences for the mother and her baby. This study will hopefully add support to public health officials’ efforts to curb cigarette use, especially in public domains.

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Positive association between high‐sensitivity C‐reactive protein and incidence of type 2 diabetes mellitus in Japanese workers: 6‐year follow‐up

Abstract: These findings imply that higher hs-CRP itself or existence of chronic systemic inflammation precedes onset of T2DM independent of obesity and smoking.

Cited by 30 publications

References 53 publications

Short Duration of Sleep Is Associated with Elevated High-Sensitivity C-Reactive Protein Level in Taiwanese Adults: A Cross-Sectional Study

Short Duration of Sleep Is Associated with Elevated High-Sensitivity C-Reactive Protein Level in Taiwanese Adults: A Cross-Sectional Study

C-Reactive Protein Promotes Diabetic Kidney Disease in db/db Mice via the CD32b-Smad3-mTOR signaling Pathway

Passive smoking as an independent risk factor for gestational diabetes that synergizes with prepregnancy obesity in urban Chinese women

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