Positioning metal-organic framework nanoparticles within the context of drug delivery – A comparison with mesoporous silica nanoparticles and dendrimers

Wuttke, Stefan; Lismont, Marjorie; Escudero, Alberto; Rungtaweevoranit, Bunyarat; Parak, Wolfgang J.

doi:10.1016/j.biomaterials.2017.01.025

Cited by 235 publications

(147 citation statements)

References 185 publications

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“…[32][33][34][35] Small organic molecular generators undergo water low solubility, and serious aggregation under physiological conditions. [39,40] Compared to the traditional inorganic/organic nanoparticles, MOF offers adjustable structural and chemical composition at the molecular level together with tunable porosity and chemical stability, which can as transport vehicles for the delivery of imaging agents and biologically active molecules realize accurate diagnosis and treatment of tumors. Metal-organic framework (MOF), as a new class of hybrid materials, consists of inorganic building units covalently connected by organic building units.…”

Section: Doi: 101002/advs201900530mentioning

confidence: 99%

A Bacteriochlorin‐Based Metal–Organic Framework Nanosheet Superoxide Radical Generator for Photoacoustic Imaging‐Guided Highly Efficient Photodynamic Therapy

et al. 2019

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Hypoxic tumor microenvironment is the bottleneck of the conventional photodynamic therapy (PDT) and significantly weakens the overall therapeutic efficiency. Herein, versatile metal–organic framework (MOF) nanosheets (DBBC‐UiO) comprised of bacteriochlorin ligand and Hf 6 (µ 3 ‐O) 4 (µ 3 ‐OH) 4 clusters to address this tricky issue are designed. The resulting DBBC‐UiO enables numerous superoxide anion radical (O 2 −• ) generation via a type I mechanism with a 750 nm NIR‐laser irradiation, part of which transforms to high toxic hydroxyl radical (OH•) and oxygen (O 2 ) through superoxide dismutase (SOD)‐mediated catalytic reactions under severe hypoxic microenvironment (2% O 2 ), and the partial recycled O 2 enhances O 2 −• generation. Owing to the synergistic radicals, it realizes advanced antitumor performance with 91% cell mortality against cancer cells in vitro, and highly efficient hypoxic solid tumor ablation in vivo. It also accomplishes photoacoustic imaging (PAI) for cancer diagnosis. This DBBC‐UiO, taking advantage of superb penetration depth of the 750 nm laser and distinct antihypoxia activities, offers new opportunities for PDT against clinically hypoxic cancer.

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Section: Doi: 101002/advs201900530mentioning

confidence: 99%

A Bacteriochlorin‐Based Metal–Organic Framework Nanosheet Superoxide Radical Generator for Photoacoustic Imaging‐Guided Highly Efficient Photodynamic Therapy

et al. 2019

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“…Metal‐organic frameworks (MOFs) are porous crystalline hybrid materials made of metal ions or clusters coordinated with organic linkers to form single or multidimensional structures . Due to the high surface area of these materials, their relatively high chemical and thermal stability, and the possibility of modifying the pore size and the functionality by changing the metal ion or the organic ligand, MOFs are useful in a wide range of fields such as catalysis, adsorption and storage of gases, selective membranes, encapsulation, and medicine …”

Section: Introductionmentioning

confidence: 99%

Solvent‐Free Encapsulation at High Pressure with Carboxylate‐Based MOFs

Monteagudo‐Olivan

Paseta

Potier³

et al. 2018

Eur J Inorg Chem

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The solvent‐free encapsulation of caffeine and kojic acid was carried out in different carboxylate‐based MOFs [MIL‐53(Al), UiO‐66 and Mg‐MOF‐74] by high pressure (0.32 GPa) contact. This methodology enables fast and ecofriendly encapsulation and gives rise to additive@MOFs with physical and features equivalent to those of materials obtained by common liquid phase encapsulation processes. It could be applied to other host–guest systems, simplifying the procedures, reducing the use and waste of harmful chemicals, and approaching the conditions of interest in the industry. The characterization carried out by thermogravimetry, X‐ray diffraction, N2 adsorption, and 13C NMR provided information about the presence and conformation of the additives in the MOFs. The highest encapsulation values for caffeine (37 %) and kojic acid (32 %) were obtained with MIL‐53(Al).

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“…As a matter of fact, MOFs exhibit some of the highest porosities (1000 to 7000 m 2 /g) of all known porous solids, with pore sizes in the range of 0.3 to 6 nm [5]. Their high porosities and, in particular, the combination of high surface area with tunable pore size render MOFs ideal for applications in gas storage and separation [6,7], catalysis [8,9,10], sensing [11,12], electronics [13], drug delivery [14,15,16,17,18], and X-ray analysis of the structures of guest molecules within the MOF scaffold [4,19]. …”

Section: Introductionmentioning

confidence: 99%

“…Recently, several reports have pointed to the general applicability of MOF nanoparticles (MOF-NPs) for drug delivery, as they have high loading capacities and are functionalizable, and certain structures have been shown to be biocompatible (e.g., MIL-100(Fe); MIL stands for Materials of Institute Lavoisier) [11,15,16,18,20,21,22,23,24,25]. MOF-NPs have been loaded with various drugs, including cisplatin [26], 5-fluorouracil [27], ibuprofen [28], doxorubicin, and cidofovir [29].…”

Section: Introductionmentioning

confidence: 99%

Kinetic Analysis of the Uptake and Release of Fluorescein by Metal-Organic Framework Nanoparticles

et al. 2017

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Metal-organic framework nanoparticles (MOF NPs) are promising guest-host materials with applications in separation, storage, catalysis, and drug delivery. However, on-and off-loading of guest molecules by porous MOF nanostructures are still poorly understood. Here we study uptake and release of fluorescein by two representative MOF NPs, MIL-100(Fe) and MIL-101(Cr). Suspensions of these MOF NPs exhibit well-defined size distributions and crystallinity, as verified by electron microscopy, dynamic light scattering, and X-ray diffraction. Using absorbance spectroscopy the equilibrium dissociation constants and maximum numbers of adsorbed fluorescein molecules per NP were determined. Time-resolved fluorescence studies reveal that rates of release and loading are pH dependent. The kinetics observed are compared to theoretical estimates that account for bulk diffusion into NPs, and retarded internal diffusion and adsorption rates. Our study shows that, rather than being simple volumetric carriers, MOF-NPs are dominated by internal surface properties. The findings will help to optimize payload levels and develop release strategies that exploit varying pH for drug delivery.

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Positioning metal-organic framework nanoparticles within the context of drug delivery – A comparison with mesoporous silica nanoparticles and dendrimers

Cited by 235 publications

References 185 publications

A Bacteriochlorin‐Based Metal–Organic Framework Nanosheet Superoxide Radical Generator for Photoacoustic Imaging‐Guided Highly Efficient Photodynamic Therapy

A Bacteriochlorin‐Based Metal–Organic Framework Nanosheet Superoxide Radical Generator for Photoacoustic Imaging‐Guided Highly Efficient Photodynamic Therapy

Solvent‐Free Encapsulation at High Pressure with Carboxylate‐Based MOFs

Kinetic Analysis of the Uptake and Release of Fluorescein by Metal-Organic Framework Nanoparticles

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