2007
DOI: 10.1590/s0036-46652007000600007
View full text |Buy / Rent full text
|
Sign up to set email alerts
|

Abstract: The high numbers of CD4+ and CD8+ TL in portal and periportal spaces and their correlation to interface hepatitis suggest that hepatitis C evolution depends on the action of intrahepatic T lymphocytes, lending support to the notion of an immune-mediated mechanism in the pathogenesis of chronic hepatitis C.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1

Citation Types

0
3
0
1

Year Published

2010
2010
2021
2021

Publication Types

Select...
3
1

Relationship

0
4

Authors

Journals

citations
Cited by 8 publications
(4 citation statements)
references
References 39 publications
(46 reference statements)
0
3
0
1
Order By: Relevance
“…The CD4/CD8 lymphocyte ratio in blood is used in the diagnosis of HIV infection [8][9][10], evaluation of pathogenesis of HCV infection [11] and autoimmune disorders such as rheumatoid arthritis or vitiligo [12,13]. The present study aimed to evaluate changes in the numbers and proportions of the peripheral blood B, NK, T CD3 + , T CD4 + and T CD8 + lymphocyte subsets, and CD4/CD8 ratio following repeated intravenous cocaine administration in rats.…”
Section: Introductionmentioning
confidence: 99%
“…The CD4/CD8 lymphocyte ratio in blood is used in the diagnosis of HIV infection [8][9][10], evaluation of pathogenesis of HCV infection [11] and autoimmune disorders such as rheumatoid arthritis or vitiligo [12,13]. The present study aimed to evaluate changes in the numbers and proportions of the peripheral blood B, NK, T CD3 + , T CD4 + and T CD8 + lymphocyte subsets, and CD4/CD8 ratio following repeated intravenous cocaine administration in rats.…”
Section: Introductionmentioning
confidence: 99%
“…Faster progression of HIV infection and increased incidence of acquired immunodeficiency syndrome (AIDS) in addicts suggests that AMPH use results in a functional impairment of the immune systems, which selectively involves the peripheral blood lymphocyte subsets, in particular, the TCD4 + /TCD8 + lymphocyte ratio. The TCD4 + /TCD8 + lymphocyte ratio in blood is used in the diagnosis of HIV infections (Pahwa et al 2008 ), hepatitis C virus (Viso et al 2007 ) and autoimmune disorders (Pichler et al 2009 ).…”
Section: Introductionmentioning
confidence: 99%
“…Since its discovery in 1989, hepatitis C virus (HCV) has been recognized as the leading cause of chronic liver disease in the world. Approximately 3% of the world population suffers from chronic hepatitis C (3,22) .…”
Section: Introductionmentioning
confidence: 99%