Portable and miniaturized optofluidic analysis system with ambient light correction for fast in situ determination of environmental pollution

Pujol‐Vila, Ferran; Giménez-Gómez, Pablo; Santamaria, Nidia; Antúnez, Bernat; Vigués, Núria; Díaz‐González, María; Jiménez-Jorquera, Cecilia; Mas, Jordi; Sacristán, J.; Muñoz-Berbel, Xavier

doi:10.1016/j.snb.2015.07.095

Cited by 22 publications

(12 citation statements)

References 22 publications

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“…In response to these issues, we aimed at creating a novel device by using another physical parameter as well as a new method to obtain the dose derived from an innovative Micro-Opto-Electro-Mechanical system (MOEMS) 23 – 27 . The system resembles those already produced by our group 28 , 29 . It consists of an optical sensor with light emitting diodes and photodetectors integrated in a mechanical and electrical system.…”

Section: Introductionmentioning

confidence: 79%

Dosimetry with gafchromic films based on a new micro-opto-electro-mechanical system

Guardiola

Márquez

Jiménez-Ramos

et al. 2021

Sci Rep

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This work presents the first tests performed with radiochromic films and a new Micro‒Opto‒Electro-Mechanical system (MOEMS) for in situ dosimetry evaluation in radiotherapy in real time. We present a new device and methodology that overcomes the traditional limitation of time-delay in radiochromic film analysis by turning a passive detector into an active sensor. The proposed system consists mainly of an optical sensor based on light emitting diodes and photodetectors controlled by both customized electronic circuit and graphical user interface, which enables optical measurements directly. We show the first trials performed in a low‒energy proton cyclotron with this MOEMS by using gafchromic EBT3 films. Results show the feasibility of using this system for in situ dose evaluations. Further adaptation is ongoing to develop a full real‒time active detector by integrating MOEM multi‒arrays and films in flexible printed circuits. Hence, we point to improve the clinical application of radiochromic films with the aim to optimize radiotherapy treatment verifications.

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Section: Introductionmentioning

confidence: 79%

Dosimetry with gafchromic films based on a new micro-opto-electro-mechanical system

Guardiola

Márquez

Jiménez-Ramos

et al. 2021

Sci Rep

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“…Vout is recorded vs. time with a LabVIEW routine. The use of modulation and Lock-in detection enables measurement of Vout with very low noise [31,32] and in the presence of ambient light. Note that the detection of light intensity ratio, as in a conventional dual beam spectrometer, rather than intensity difference as we do here, would cancel intensity modulation and thus disable Lock-in detection.…”

Section: Methodsmentioning

confidence: 99%

Fibre optic absorbance meter with low limit of detection for waterborne cations

Tuwei

Williams

Grell

2016

Sensors and Actuators B: Chemical

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We report an evanescent wave based fibre optic absorbance meter that enables the colorimetric detection of waterborne cations with water insoluble chromoionophoric sensitisers. This establishes an alternative to the PVC membrane based transducers that are conventionally used for this purpose. Here, a water insoluble sensitiser is coated as a thin film on an unclad section of a multimode optical fibre to overlap with the evanescent field of a light beam propagating along the fibre core. The colorimetric response of the sensitiser when in contact with waterborne cation leads to increased absorption of virtual photons associated with the evanescent field. The resulting intensity loss of the propagating beam is detected by a bespoke newly designed self-referenced evanescent wave absorbance meter with beam intensity modulation and Lock-in amplification. We validate our transducer with the well characterised water insoluble sensitizer, 1-(2-pyridylazo)-2-naphthol (PAN), for the detection of aqueous Zn 2+ cations. We find a limit of detection (LoD) of 54 nM Zn 2+ , 28 times lower compared to a PVC membrane based sensor using same sensitiser for same cation (Albero et al., Journal of Pharmaceutical and Biomedical Analysis 29 (2002), 779). Our evanescent wave absorbance meter can easily be adapted to other colorimetric sensitisers, including chromoionophoric complex forming macrocycles.

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“…All the samples were analysed with the bi-parametric compact analytical flow-system. The wine samples were diluted to adjust the l-malic acid and the l-lactic acid concentrations to the linear range of the individual biosensors obtained previously in our group (from 5 × 10 -6 to 1 × 10 -4 M and from 1 × 10 -7 to 1 × 10 -6 M, for the l-lactate and the l-malate, respectively) 14,15 . The wine samples were eventually diluted 1:10,000 by carrying out two intermediate dilutions of 1:100 in a 0.05 M PB solution (pH 7) containing 0.5 M KCl to adjust the l-malic acid concentration to the linear range of the biosensor.…”

Section: Red Wine Samples From Malolactic Fermentation Three Differementioning

confidence: 99%

“…The most common polymer used in fluidic systems is the polymethyl methacrylate (PMMA) 8 because it is rigid, hard and very easy to manufacture by fast-prototyping techniques (i.e. milling and laser ablation) [9][10][11][12][13][14] . Regarding the sensing part of the device, the electrochemical biosensors have been extensively reported as the best chance for the monitoring of analytical processes, including food control.…”

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confidence: 99%

Compact analytical flow system for the simultaneous determination of l-lactic and l-malic in red wines

Giménez-Gómez

Gutiérrez-Capitán

Capdevila

et al. 2020

Sci Rep

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During the malolactic fermentation of red wines, l-malic acid is mainly converted to l-lactic acid. Both acids should be precisely measured during the entire process to guarantee the quality of the final wine, thus making real-time monitoring approaches of great importance in the winemaking industry. Traditional analytical methods based on laboratory procedures are currently applied and cannot be deployed on-site. In this work, we report on the design and development of a bi-parametric compact analytical flow system integrating two electrochemical biosensors that could be potentially applied in this scenario. The developed flow-system will allow for the first time the simultaneous measurement of both acids in real scenarios at the real-time and in remote way. Miniaturized thin-film platinum four-electrode chips are fabricated on silicon substrates by standard photolithographic techniques and further implemented in a polymeric fluidic structure. This includes a 15 µL flow cell together with the required fluidic channels for sample and reagent fluid management. The four-electrode chip includes counter and pseudo-reference electrodes together with two working electrodes. These are sequentially modified with electropolymerized polypyrrole membranes that entrap the specific receptors for selectively detecting both target analytes. The analytical performance of both biosensors is studied by chronoamperometry, showing a linear range from 5 × 10−6 to 1 × 10−4 M (LOD of 3.2 ± 0.3 × 10−6 M) and from 1 × 10−7 to 1 × 10−6 M (LOD of 6.7 ± 0.2 × 10−8 M) for the l-lactate and the l-malate, respectively. Both biosensors show long-term stability, retaining more than the 90% of their initial sensitivity after more than 30 days, this being a prerequisite for monitoring the whole process of the malolactic fermentation of the red wines (time between 20 and 40 days). The flow system performance is assessed with several wine samples collected during the malolactic fermentation process of three red wines, showing an excellent agreement with the results obtained with the standard method.

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Portable and miniaturized optofluidic analysis system with ambient light correction for fast in situ determination of environmental pollution

Cited by 22 publications

References 22 publications

Dosimetry with gafchromic films based on a new micro-opto-electro-mechanical system

Dosimetry with gafchromic films based on a new micro-opto-electro-mechanical system

Fibre optic absorbance meter with low limit of detection for waterborne cations

Compact analytical flow system for the simultaneous determination of l-lactic and l-malic in red wines

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