Porphyria turcica. Twenty years after hexachlorobenzene intoxication

Cripps, Derek J.; Göçmen, A; Peters, H.F.M.

doi:10.1001/archderm.116.1.46

Cited by 32 publications

(3 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hexachlorobenzene (HCB) is an organochlorine compound that has been produced since 1933 (Barber et al 2005 ). It was widely used in the 1940s and 1950s as a fungicidal wood-preserving agent and to control wheat bunt (Cripps et al 1980 ; Gocmen et al 1986 ). At its peak, global HCB emissions have been estimated at up to 92,000 kg/year (Bailey 2001 ).…”

Section: Introductionmentioning

confidence: 99%

The history of hexachlorobenzene accumulation in Svalbard fjords

Pouch

Zaborska

Pazdro

2018

Environ Monit Assess

View full text Add to dashboard Cite

In the present study, we investigated the spatial and historical trends of hexachlorobenzene (HCB) contamination in dated sediments of three Svalbard fjords (Kongsfjorden, Hornsund, Adventfjorden) differing in environmental conditions and human impact. HCB concentrations ranging from below limit of quantification (6.86 pg/g d.w.) to 143.99 pg/g d.w. were measured. The highest concentrations were measured in two surface sediment layers of the core collected in Hornsund near the melting glacier. The lowest concentrations of HCB were measured in Adventfjorden, suggesting that local source of HCB is not significant and global transport processes are the major transport pathways. The history of HCB deposition did not fully reflect the history of HCB emission (largest in 1950s and 1960s). In case of several sediment cores, the HCB enrichment in surface (recent) sediments was noticed. This can indicate importance of secondary sources of HCB, e.g., the influx of HCB accumulated over decades on the surface of glaciers. Detected levels of HCB were generally low and did not exceed background concentration levels; thus, a negative effect on benthic organisms is not expected.Electronic supplementary materialThe online version of this article (10.1007/s10661-018-6722-3) contains supplementary material, which is available to authorized users.

show abstract

Section: Introductionmentioning

confidence: 99%

The history of hexachlorobenzene accumulation in Svalbard fjords

Pouch

Zaborska

Pazdro

2018

Environ Monit Assess

View full text Add to dashboard Cite

show abstract

“…Specifically, very little information is available regarding health effects in infants following exposure to breast milk contaminated with pesticides. One welldocumented exception is the late 1950s incident in Eastern Turkey that involved about 4000 individuals poisoned by HCB that was added to wheat seedlings and processed into flour (Cripps et al, 1980(Cripps et al, , 1984Peters et al, 1982) . Many of the children under the age of 1 year who were breast -fed by mothers exposed to HCB ( i.e., high -level exposure) died from a disease known as pembe yara ( pink sore ) that was associated with weakness, convulsions, and annular erythema.…”

Section: Pohl and Tylendamentioning

confidence: 99%

Breast-feeding exposure of infants to selected pesticides: a public health viewpoint

Pohl

Tylenda

2000

Toxicol Ind Health

View full text Add to dashboard Cite

In this paper, we provide an overview of the public health implications of exposure to some pesticides via breast milk and provide health-based guidance. The presence of organochlorine pesticides in breast milk has been documented in many studies around the world. Included in our review are aldrin/dieldrin, chlordane, 1,1,1-trichloro-2,2-bis(p-chlorophenyl) ethane (DDT)/1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), endrin, hexachlorobenzene (HCB), and hexachlorocyclohexane (HCH). Toxicological and environmental data on these chemicals are compiled in toxicological profiles published by the Agency for Toxic Substances and Disease Registry (ATSDR). Based on the data, ATSDR derives chemical-specific minimal risk levels (MRLs) that assist in evaluating public health risks associated with exposure. MRLs are health-based guidance values designed to protect the most sensitive populations, including breast-fed infants. We compare MRLs and projected intakes from the breast milk for the listed pesticides, explore the possibilities of toxicological interactions, and provide health-based recommendations.

show abstract

“…In a study 20-25 years after the epidemic, among 204 patients with a prior history of hexachlorobenzene-induced porphyria (Cripps et al 1980, Gocmen et al 1986) a picture of chronic disease was found which includes skin hyperpigmentation, hypertrichosis, scarring of the face and hands, painless arthritis, weakness, paraesthesia and myotonia. Less frequently, enlarged liver and thyroid and a recent history of red urine were found.…”

Section: Organochlorine Insecticides and Fungicidesmentioning

confidence: 99%

Toxic epidemics caused by alimentary exposure to pesticides: A review

Ferrer

Cabral

1991

Food Additives and Contaminants

View full text Add to dashboard Cite

Toxic epidemics have become a serious problem during the twentieth century, due mainly to the huge expansion over the last 50 years of the chemical industry, which has placed tens of thousands of new synthetic organic compounds in the human environment. In the particular case of chemical pesticides, their undiscriminating, widespread use, and harmful potential has been demonstrated by the epidemics generated by accidental contamination by pesticides of foods consumed by man, resulting in high mortality and morbidity rates. We have analysed the main characteristics of 63 outbreaks of toxicity caused by alimentary exposure to pesticides described in the scientific literature of this century, with the aim of increasing knowledge and understanding of the factors that are conducive to them or that trigger their onset. Such episodes are good indicators of the incorrect use of these products and serve to demonstrate failures of the available safety systems. We conclude by identifying some preventive measures that could be used to avoid their future repetition.

show abstract

Porphyria turcica. Twenty years after hexachlorobenzene intoxication

Cited by 32 publications

References 9 publications

The history of hexachlorobenzene accumulation in Svalbard fjords

The history of hexachlorobenzene accumulation in Svalbard fjords

Breast-feeding exposure of infants to selected pesticides: a public health viewpoint

Toxic epidemics caused by alimentary exposure to pesticides: A review

Contact Info

Product

Resources

About