Porphyria cutanea tarda treated with chloroquine phosphate

Bloom, Martin

doi:10.1001/archderm.100.3.375

Cited by 10 publications

(5 citation statements)

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“…It was ascertained by that time that this drug releases porphyrins from their liver stores and stimulates their excretion in the urine. Soon, however, it became obvious that higher doses of chloroquine can give rise to fever, malaise, headache, nausea, constipation and abdominal pain, and for some time the attitude to this new therapeutic approach was rather cautious (Cripps & Curtis, 1962;Sweeney et al, 1965;Bloom, 1969;Reed, 1974).…”

Section: Discussionmentioning

confidence: 99%

“…While it has been confirmed that repeated phlebotomies do not damage the liver parenchyma in PCT (Chlumsky, Chlumska & Malina, 1973;Malina, Chlumsky & Chlumska, 1974), the effect of chloroquine on the function and morphology of hepatic tissue is not yet sufficiently known. Several opinions have been expressed on the possible impairment of the liver parenchyma due to the drug (Cripps & Curtis, 1962;Sweeney et al, 1965;Bloom, 1969;Reed, 1974).…”

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confidence: 99%

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Liver changes in porphyria cutanea tarda patients treated with chloroquine

1980

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In thirty-four patients with porphyria cutanea tarda treated with small doses of chloroquine, liver biopsies were performed before and after treatment. In seventeen cases (50%) the morphological patterns before treatment corresponded to unstabilized fibrosis, while in eleven (32.4%) there were non-specific changes in the form of focal fatty change, haemosiderosis, and mild fibrosis of the portal tracts. Active chronic hepatitis was found in three patients (8.8%), and cirrhosis also in three cases. Although in all patients a clinical and metabolic remission of porphyria cutanea tarda occurred during treatment, the morphological patterns in the liver parenchyma remained on the whole unchanged. Only in five cases was there an increase in the inflammatory changes, while in two patients these changes tended to disappear.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Liver changes in porphyria cutanea tarda patients treated with chloroquine

1980

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“…Dies führte jedoch zu derart schweren Leberschädigungen, daß einige Autoren vor der Therapie der P.c.t. mit Chloroquin warnten und sie ablehnten (Bloom 1969;Gripps und Curtis 1982;Swanbeck und Wennersten 1977;Goerz und Krieg 1978;Raff und Formanek 1980;Horkay und Nagy 1980). Dieses "Flu"-Syndrom war begleitet von einem deutlichen Anstieg der Transaminasen (GOT und GPT) im Blut.…”

Section: Diskussionunclassified

Tod nach gabe von 1250mg chloroquin bei porphyria cutanea tarda

Drasch¹,

Eisenmenger²

1986

Z Rechtsmed

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“…Hence the quest for a safe, effective agent has continued. Chloroquine employed in dosage of the order of 0-5 to 1-0 g daily was found to be highly effective in reducing liver stores of porphyrin in PCT and promoting clinical improvement (Felsher and Redeker, 1966); but this regimen was not generally acceptable in view of the accompanying acute reaction, which in some patients can be alarming (Bloom, 1969).…”

Section: Patient Studymentioning

confidence: 99%

Studies on Low Dose Chloroquine Therapy and the Action of Chloroquine in Symptomatic Porphyria

et al. 1972

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Eight patients with symptomatic porphyria (porphyria cutanea tarda symptomatica, PCT) were treated with smalt doses of chloroquin sulphate over periods ranging from 2 to 16 weeks. A good clinical and biochemical response was obtained in all but one patient, who relapsed after initial improvement. Manifestations of acute untoward reaction were seen in one patient only. It is concluded that low dose chloroquine therapy is both safe and effective in PCT.Studies in porphyric rats indicate that the mechanism of action of chloroquine in PCT is probably not related, as has been suggested, to the formation of a chloroquine-porphyrin complex which damages liver cells and thereby leads to a reduction in hepatic porphyrin stores.Chloroquine therapy led to increased urinary iron excretion and an increase in the desferrioxamine-chelatable iron in patients with PCT. It is suggested that the prolonged beneficial effects of chloroquine treatment may be related to reduction in a specific pool of liver iron.

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Porphyria cutanea tarda treated with chloroquine phosphate

Cited by 10 publications

References 0 publications

Liver changes in porphyria cutanea tarda patients treated with chloroquine

Liver changes in porphyria cutanea tarda patients treated with chloroquine

Tod nach gabe von 1250mg chloroquin bei porphyria cutanea tarda

Studies on Low Dose Chloroquine Therapy and the Action of Chloroquine in Symptomatic Porphyria

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