1982
DOI: 10.1001/archderm.118.3.160
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Porphyria cutanea tarda and systemic lupus erythematosus

Abstract: Fifty-five patients with porphyria cutanea tarda (PCT) were examined for the simultaneous occurrence of systemic lupus erythematosus (SLE). The diagnostic criteria for SLE were those set up by the American Rheumatism Association (ARA). No patient fulfilled the ARA criteria for SLE. Clinical and laboratory features characteristically associated with SLE (although they were not ARA criteria) were simultaneously evaluated. A total of 120 items occurred in those cases but only 15 of these were ARA criteria. These … Show more

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Cited by 13 publications
(7 citation statements)
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“…A test for hepatitis B was done in 78 patients, with no positive results. In 80 patients a test for antinuclear factor (ANA) was done because of reported co-existence of systemic lupus erythematosus (SLE) and PCT (17), findings not confirmed in later studies (18,19).…”
Section: Methodsmentioning
confidence: 99%
“…A test for hepatitis B was done in 78 patients, with no positive results. In 80 patients a test for antinuclear factor (ANA) was done because of reported co-existence of systemic lupus erythematosus (SLE) and PCT (17), findings not confirmed in later studies (18,19).…”
Section: Methodsmentioning
confidence: 99%
“…96 Some authors associate glucose intolerance to the presence of the hemochromatosis gene rather than to PCT. 97 Other associated conditions to PCT are systemic lupus erithematosus 98 or discoid lupus, 99 dermatomyositis, 6 systemic sclerosis, 86 hematological disorders, 100 sideroblastic anemia, 11 thalassemia 11 and cytomegalovirus infection. 80 …”
Section: Associated Conditionsmentioning
confidence: 99%
“…The porphyrias have been described in association with a variety of autoimmune disorders.8 Two previous studies have failed to show an increased incidence of connective tissue disease in patients with porphyria cutanea tarda, though non-specific immunological abnormalities, such as raised ESR and immunoglobulins, were common.9 10 Although the association of SLE and acute porphyria has been described in several case reports, there have been no previous studies including patients with acute porphyria. The presence of ANAs in acute intermittent porphyria, which were not found in latent disease, might conceivably appear following cell damage after an acute porphyric attack.…”
Section: Discussionmentioning
confidence: 99%