Porphyria cutanea tarda and hepatitis C viral infection. A clinical and virologic study

Cribier, B.

doi:10.1001/archderm.131.7.801

Cited by 15 publications

(7 citation statements)

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“…Nevertheless, no physiopathologic data have demonstrated how HCV can induce or trigger skin conditions. In at least 2 cutaneous diseases-mixed cryoglobulinemia 3 and porphyria cutanea tarda 4 -HCV plays an important role. The link between HCV and lichen planus is likely to be important, although this point remains controversial.…”

Section: Main Outcome Measuresmentioning

confidence: 99%

Chronic Urticaria Is Not Significantly Associated With Hepatitis C or Hepatitis G Infection

Cribier¹,

Santinelli²,

Schmitt³

et al. 1999

Arch Dermatol

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Section: Main Outcome Measuresmentioning

confidence: 99%

Chronic Urticaria Is Not Significantly Associated With Hepatitis C or Hepatitis G Infection

Cribier¹,

Santinelli²,

Schmitt³

et al. 1999

Arch Dermatol

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“…We have reported previously a high frequency of HCV infection in Italian patients with sporadic PCT [10], an observation later confirmed in other series from different geographical areas, including Scotland [11], France [12,13], Bulgaria [14], Spain [15,16], Japan [17], Brazil [18] and the United States [5,9,19]. HCV infection has been associated with a variety of immunopathological manifestations, including mixed cryoglobulinaemia [20,21], glomerulonephritis [22], thyroid disease [23,24] and anti‐liver kidney microsomal antibody type 1 (LKM1) positive autoimmune hepatitis (AIH) [25,26].…”

Section: Introductionmentioning

confidence: 71%

Autoantibodies to human cytosol: a marker of sporadic porphyria cutanea tarda

Fracanzani

Sampietro

et al. 2001

Clinical and Experimental Immunology

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SUMMARYThe enzymes potentially involved in the pathogenesis of sporadic porphyria cutanea tarda (PCT) reside in liver cytosoles and microsomes. PCT is frequently associated with hepatitis C virus (HCV) infection, which is in turn associated with autoimmune manifestations. To investigate whether autoimmune reactions, possibly triggered by HCV, are involved in the pathogenesis of PCT, we measured by immunoblot autoantibodies to human cytosolic and microsomal liver fractions in 82 patients with PCT (77% with HCV infection), 105 with other liver disorders and 40 healthy subjects. Anti-liver cytosolic antibodies were more frequent in PCT patients (38/82, 46%) than in pathological controls (P , 0´05± P , 0´001) or in healthy subjects (3/40, 8%, P , 0´001). Among PCT patients, anticytosolic antibodies were more frequent in HCV positive (36/63, 57%) than in HCV negative (2/19, 11%, P , 0´05) cases. Reactivity to a 40-kDa cytosolic polypeptide was present in 20 PCT patients (19 HCV positive), being more frequent than in all pathological controls (P , 0´01±P , 0´0001). Histological activity index (P 0´04) and antibodies to HCV (P 0´027) ± but not HCV RNA ± were associated independently with anticytosolic antibodies as assessed by multivariate analysis. In contrast, frequency of antiliver microsomal antibodies was similar in PCT patients (24/82, 29%) and pathological controls (8±26%), being higher in the autoimmune hepatitis control group (23/23, 100%, P , 0´0001). In conclusion, anticytosolic antibodies, particularly to a 40-kDa polypeptide, are frequent in PCT and associated with HCV infection and severity of liver damage.

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“…Hepatitis B, C (18,20) and HIV (12) virus infections may also contribute to the development of PCT. Prevelance of hepatitis C is rather high in PCT and in leukemia patients.…”

Section: Discussionmentioning

confidence: 99%

Porphyria cutanea tarda and chronic lymphoid leukemia

Remenyik

Ujj

Kiss

et al. 1996

Photoderm Photoimm Photomed

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A case of a familial porphyria cutanea tarda (PCT-II) is reported in which the clinically overt form of PCT was provoked by factors relating to chronic lymphoid leukemia (CLL). Typical lesions of PCT developed on a 55-year-old woman after several blood transfusions and chlorambucil treatment. Besides these provoking factors, cytomegalovirus (CMV) infection was diagnosed. Erythrocyte uroporphyrinogen decarboxylase activity was about 50% of normal in the patient and in her two children. This case supports the suggestion that development of PCT in patients with hematological disorders is more than coincidental but may in fact be provoked by exogenous factors relating to the treatment of leukemia.

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Porphyria cutanea tarda and hepatitis C viral infection. A clinical and virologic study

Cited by 15 publications

References 0 publications

Chronic Urticaria Is Not Significantly Associated With Hepatitis C or Hepatitis G Infection

Chronic Urticaria Is Not Significantly Associated With Hepatitis C or Hepatitis G Infection

Autoantibodies to human cytosol: a marker of sporadic porphyria cutanea tarda

Porphyria cutanea tarda and chronic lymphoid leukemia

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