Porphyran induces apoptosis related signal pathway in AGS gastric cancer cell lines

Kwon, Mijin; Nam, Taek‐Jeong

doi:10.1016/j.lfs.2006.06.031

Cited by 127 publications

(58 citation statements)

References 35 publications

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“…Although 9 various biological activities of alginate and its oligomers have been found in in vivo and in vitro systems (26)(27)(28)(29)(30), no cytotoxic or direct cell killing activity of alginates has been reported so far. Porphyran, an alga-derived polysaccharide containing sulfate ester, is known to show inhibitory effects on the proliferation of tumor cells (31). In this case, the sulfate esters of the bioactive polysaccharides may play an important role in the signaling pathway leading to the arrest of the proliferation of sensitive cells.…”

Section: Resultsmentioning

confidence: 99%

Effects of sulfated fucan, ascophyllan, from the brown Alga Ascophyllum nodosum on various cell lines: A comparative study on ascophyllan and fucoidan

Jiang

Okimura²,

Yokose

et al. 2010

Journal of Bioscience and Bioengineering

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Abstract:The effects of fucose-containing sulfated polysaccharides, ascophyllan and fucoidan, isolated from the brown alga Ascophyllum nodosum, on the growth of various cell lines (MDCK, Vero, PtK 1 , CHO, HeLa, and XC) were investigated. In a colony formation assay, ascophyllan and fucoidan showed potent cytotoxic effects on Vero and XC cells, while other cell lines were relatively resistant to these polysaccharides. Almost no significant effects of these polysaccharides were observed in the cell lines tested using the Alamar blue cytotoxicity assay over 48 h with varying initial cell densities (2500-20,000 cells/well) in growth medium. Interestingly, a significant growth promoting effect of ascophyllan on MDCK cells was observed, whereas treatment with fucoidan showed growth suppressive effects on this cell line under the same experimental conditions. These results suggest that ascophyllan is distinguishable from fucoidan in terms of their bioactivities. This is the first report of the growth promoting effects of a sulfated fucan on a mammalian cell line under normal growth conditions. 4

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Section: Resultsmentioning

confidence: 99%

Effects of sulfated fucan, ascophyllan, from the brown Alga Ascophyllum nodosum on various cell lines: A comparative study on ascophyllan and fucoidan

Jiang

Okimura²,

Yokose

et al. 2010

Journal of Bioscience and Bioengineering

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“…has been studied in vitro (6,9,13,16) and in vivo (10,4,12) assays. Polysaccharides produced by the red algae Porphyra sp.…”

Section: Discussionmentioning

confidence: 99%

“…Polysaccharides produced by the red algae Porphyra sp. such as porphyran and Porphyra yezoensis polysaccharide have been reported to have immunoregulatory, antioxidant and antitumour activities (6,9,12,13) . Porphyran inhibited cancer cell growth by decreasing cell proliferation and inducing apoptosis in AGS gastric cancer cell lines (6) .…”

Section: Discussionmentioning

confidence: 99%

“…Antioxidant and antimutagenic effects of dietary seaweeds have been reported in vitro (6 -8) and in vivo studies (9 -11) . Polysaccharides (6,9,12,13) , proteins (14) , antioxidants (e.g. ascorbate, glutathione and carotenoids) (15,16) , polyphenols (7) and extracts (7,17) of seaweeds have been reported to have antioxidant, antitumour and chemoprotective activities.…”

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confidence: 99%

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A case–control study on seaweed consumption and the risk of breast cancer

et al. 2009

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Gim (Porphyra sp.) and miyeok (Undaria pinnatifida) are the seaweeds most consumed by Koreans. We investigated the association between the intake of gim and miyeok and the risk of breast cancer in a case -control study. Cases were 362 women aged 30 -65 years old, who were histologically confirmed to have breast cancer. Controls visiting the same hospital were matched to cases according to their age (SD 2 years) and menopausal status. Food intake was estimated by the quantitative FFQ with 121 items, including gim and miyeok. Conditional logistic regression analysis was used to obtain the OR and corresponding 95 % CI. The average intake and consumption frequency of gim in cases were lower than in controls. The daily intake of gim was inversely associated with the risk of breast cancer (5th v. 1st quintile, OR, 0·48; 95 % CI, 0·27, 0·86; P for trend, 0·026) after adjustment for potential confounders. After stratification analysis was performed according to menopausal status, premenopausal women (5th v. 1st quintile, OR, 0·44; 95 % CI, 0·24, 0·80; P for trend, 0·007) and postmenopausal women (5th v. 1st quintile, OR, 0·32; 95 % CI, 0·13, 0·80; P for trend, 0·06) showed similar inverse associations between gim intake and the risk of breast cancer after an adjustment for potential confounders except dietary factors. Miyeok consumption did not have any significant associations with breast cancer. These results suggest that high intake of gim may decrease the risk of breast cancer.

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“…contained sulphated polysaccharides (porphyrans) that have been showed to present potential antitumor activity through apoptotic mechanism. 45 Kwon et al 46 found that the ethanolic extracts of Corallina pilulifera (EECP) showed cytotoxic activity against human cervical adenocarcinoma cell line, HeLa (IC 50 = 250 μg/ml). Treatment of HeLa cells with various concentrations of EECP resulted in growth inhibition and induction of apoptosis in a dose-dependent manner.…”

mentioning

confidence: 99%