Porous silicon nanoparticles as sensitizers for ultrasonic hyperthermia

Sviridov, Andrey; Андреев, В. Г.; Иванова, Е. А.; Осминкина, Л. А.; Tamarov, Konstantin; Timoshenko, V. Yu.

doi:10.1063/1.4829148

Cited by 89 publications

(61 citation statements)

References 15 publications

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“…First, Si NPs are not only biocompatible12, but also biodegradable as in biological tissue they normally decay into orthosilicic acid Si(OH) 4 , which is naturally excreted from the body through the urine13. Second, due to a series of unique properties, including room temperature photoluminescence1213, singlet oxygen generation under photoexcitation14, infrared radiation–induced15 and ultrasound-induced16 hyperthermia, Si NPs can offer diagnostic1718 and alternative treatment modalities (e.g., Photodynamic Therapy1920) that can be applied in parallel to the RF hyperthermia approach.…”

mentioning

confidence: 99%

Radio frequency radiation-induced hyperthermia using Si nanoparticle-based sensitizers for mild cancer therapy

Tamarov

Осминкина

Zinovyev

et al. 2014

Sci Rep

158

156

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Offering mild, non-invasive and deep cancer therapy modality, radio frequency (RF) radiation-induced hyperthermia lacks for efficient biodegradable RF sensitizers to selectively target cancer cells and thus avoid side effects. Here, we assess crystalline silicon (Si) based nanomaterials as sensitizers for the RF-induced therapy. Using nanoparticles produced by mechanical grinding of porous silicon and ultraclean laser-ablative synthesis, we report efficient RF-induced heating of aqueous suspensions of the nanoparticles to temperatures above 45-50°C under relatively low nanoparticle concentrations (<1 mg/mL) and RF radiation intensities (1–5 W/cm2). For both types of nanoparticles the heating rate was linearly dependent on nanoparticle concentration, while laser-ablated nanoparticles demonstrated a remarkably higher heating rate than porous silicon-based ones for the whole range of the used concentrations from 0.01 to 0.4 mg/mL. The observed effect is explained by the Joule heating due to the generation of electrical currents at the nanoparticle/water interface. Profiting from the nanoparticle-based hyperthermia, we demonstrate an efficient treatment of Lewis lung carcinoma in vivo. Combined with the possibility of involvement of parallel imaging and treatment channels based on unique optical properties of Si-based nanomaterials, the proposed method promises a new landmark in the development of new modalities for mild cancer therapy.

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mentioning

confidence: 99%

Radio frequency radiation-induced hyperthermia using Si nanoparticle-based sensitizers for mild cancer therapy

Tamarov

Осминкина

Zinovyev

et al. 2014

Sci Rep

158

156

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“…Additional scattering caused by these so-called sonosensitizers becomes the source of supplementary ultrasound attenuation which consequently leads to increase in temperature [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Dependence of Ultrasonic and Magnetic Hyperthermia on the Concentration of Magnetic Nanoparticles

et al. 2018

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Hyperthermia treatment is the heating of tumor tissue up to temperatures between 41 ¥ C and 45 ¥ C, which trigger several physiological reactions in the body. Hyperthermia within tissue can be applied through various mechanisms. One of them is magnetic hyperthermia which uses superparamagnetic iron oxide nanoparticles (SPIONs) heated by an externally applied magnetic field. SPIONs can also be used as sonosensitizers in ultrasound hyperthermia increasing acoustic wave attenuation. The impact of SPION concentration on thermal effect during ultrasonic and magnetic hyperthermia was investigated in agar-gel phantom with added magnetite nanoparticles. The presence of nanoparticles in the tissue-mimicking phantom increases the thermal losses of ultrasound energy and temperature of the phantom.

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“…The heating of suspensions was much stronger because of the additional absorption of ultrasonic waves by the nanoparticles [6].…”

Section: Extended Abstractmentioning

confidence: 99%

Selectively Modified Porous Silicon Nanoparticles as Sonosensitizers of Therapeutic Ultrasound

Sviridov¹,

Tamarov²,

Timoshenko³

et al. 2017

Proceedings of the 2nd World Congress on New Technologies

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Extended AbstractOne of the most actively developed methods for the therapy of some types of cancer is HIFU-surgery using high intensity focused ultrasound [1]. For its utilization, HIFU therapy involves extremely high acoustic intensities (~ 0.1-1 kW/cm 2 ), which may cause too negative influence on healthy tissues of a human body. HIFU surgery is limited by the USI selectivity, which is necessary to achieve therapeutic effect relative to vast tumors and individual cells. The effectiveness of ultrasound (USI) for biomedical purposes can be significantly improved by several substances enhancing its action, or sonosensitizers [2]. Sonosensitizers based on porous silicon (PSi), which properties of biocompatibility [3] and biodegradability [4] have been proved in various in vitro and in vivo experiments, can be used as such agents. The purpose of the present work is experimental and theoretical study of thermal and cavitation effects in aqueous suspensions of mesoporous silicon nanoparticles (PSiNPs).The PSi films were formed by a standard method of electrochemical etching of crystalline silicon wafers. The samples of selectively modified PSiNPs with hydrophilic outer surface and hydrophobic pore walls were fabricated using hexane as a nano-stopper of pore oxidation and high-energy grinding of PSi films in aqueous medium. TEM, DLS and IRspectroscopy techniques were used to determine size distributions and surface chemistry of the prepared samples.The scheme of experimental setup used for USI measurements was as followed. A hollow cuvette filled with an investigated sample was placed into a water tank and exposed to the field of calibrated MHz transducer. Temperature was controlled by E-type thermocouples. The transmitted signal was detected with a sensitive hydrophone. The experiment was automated via a program developed in the LabVIEW environment, which provided control of the generated signal and measurement of time, signal spectrum detected by the hydrophone and temperature.The spectrum of transmitted signal registered by the hydrophone was obtained using FFT. Besides the fundamental harmonic, it contained multiple harmonics including the subharmonic, which is an evidence of active cavitation in the sample. Time dependences of the main harmonic amplitudes (the half, fundamental and second ones) for the samples of PSiNP suspensions and pure water at various USI intensities were recorded.Average magnitudes of subharmonic for the samples of oxidized, selectively modified PSiNPs and pure water under exposure to ultrasound of different intensities were obtained. It was revealed that the intensity threshold for the suspension of PSiNPs was significantly lower as compared to water, while the lowest values were observed for the sample of selectively modified SiNPs. This effect can be explained by the presence of nucleation bubbles in the porous structure of nanoparticles, which promote the cavitation process [5].The heating of PSiNP suspensions and pure water was measured as well. The heating of suspensions was much str...

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Porous silicon nanoparticles as sensitizers for ultrasonic hyperthermia

Cited by 89 publications

References 15 publications

Radio frequency radiation-induced hyperthermia using Si nanoparticle-based sensitizers for mild cancer therapy

Radio frequency radiation-induced hyperthermia using Si nanoparticle-based sensitizers for mild cancer therapy

Dependence of Ultrasonic and Magnetic Hyperthermia on the Concentration of Magnetic Nanoparticles

Selectively Modified Porous Silicon Nanoparticles as Sonosensitizers of Therapeutic Ultrasound

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