Porous Silicon as a Nanomaterial for Disperse Transport Systems of Targeted Drug Delivery to the Inner Ear

Spivak, Yu. M.; Belоrus, Anton O.; Panevin, A. A.; Zhuravskii, S. G.; Мошников, В. А.; Bespalova, Kristina; Somov, Pavel A.; Zhukov, Yu. M.; Komolov, A. S.; Chistyakova, L. V.; Grigor’eva, N. Yu.

doi:10.1134/s1063784218090207

Cited by 21 publications

(12 citation statements)

References 24 publications

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“…addition of isopropyl alcohol (С 3 H 7 OH) was used. This solution provides the necessary wettability of the silicon wafer surface by electrolyte [22][23][24][25].…”

Section: The Formation Of Porous Silicon Matrices By Electrochemical mentioning

confidence: 99%

Study of Composite Structures Based on a Porous Silicon Matrix and Nanoparticles Ag/Zno Used as Non-Invasive Highly Sensitive Biosensor Devices

Koshevoi¹,

Belоrus²,

Pleshanov³

et al. 2021

Composite Materials

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In this work composite structures based on a porous silicon were obtained and studied. Porous matrices were formed by electrochemical etching in aqueous solutions of hydrofluoric acid. Based on the obtained substrates, por-silicon (Si)/silver (Ag) and por-Si/zinc oxide (ZnO) composite structures were formed. These composites were functionalized by various methods (electro (E)-, thermo (T)-, electrothermal exposure) as a result of which the structures were modified. When studying the samples by scanning electron microscopy (SEM), it was concluded that silver nanoparticles actively diffused into the pores under these technological modes of functionalization. The por-Si/Ag and por-Si/ZnO composite structures were also studied using the following methods: infrared (IR) spectroscopy and Raman ultrasoft X-ray emission spectroscopy. Also, the photoluminescent characteristics of the samples were studied. Based on the obtained results, it was concluded that functionalization methods actively change the phase composition of structures and the optical properties of composites.

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“…addition of isopropyl alcohol (С 3 H 7 OH) was used. This solution provides the necessary wettability of the silicon wafer surface by electrolyte [22][23][24][25].…”

Section: The Formation Of Porous Silicon Matrices By Electrochemical mentioning

confidence: 99%

Study of Composite Structures Based on a Porous Silicon Matrix and Nanoparticles Ag/Zno Used as Non-Invasive Highly Sensitive Biosensor Devices

Koshevoi¹,

Belоrus²,

Pleshanov³

et al. 2021

Composite Materials

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“…To control and to verify the presence of photoluminescent PLPor-Si nanoparticles in the tissues after internalization, several experiments were previously performed on the injection of unloaded shell-free carriers (PLPor-Si) using a method similar to that for carrier particles loaded with medication (PLPor-Si-Gent) and coated with dextran (DPLPor-Si and DPLPor-Si-Gent) [53]. The study of the fragments of the rat's liver and heart tissues using the SEM method after an intravenous injection of por-Si particles (from the first set) revealed the presence of electron-dense particles with a shape close to spherical.…”

Section: Characterization and Study Of Fluorescence Of Plpor-si Nanopmentioning

confidence: 99%

Fluorescent Nanoagents for Biomedical Applications

Королев¹,

Istomina²,

Belоrus³

et al. 2020

Fluorescence Methods for Investigation of Living Cells and Microorganisms

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Fluorescence imaging is a promising method widely used for the evaluation of the biodistribution and accumulation of various fluorescent agents cross-linked to the drug for effective therapy control. This work presents the methods for the functionalization of nanomaterials to provide them with fluorescent properties. The first of these methods is a unique technology for producing porous silicon with fluorescent properties. The second approach demonstrates linking of the fluorophores to inorganic nanoparticles (NP) using a spacer molecule ending with a functional group. For all these examples of fluorophores, biodistribution studies were performed with the fluorescent imaging system IVIS Lumina LT III (PerkinElmer, USA). It was noted that the size of particles and the method of their injection affect the distribution and accumulation in organs. The resulting materials can be used to develop platforms for theranostics.

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“…на основе кремния (por-Si) В работе для формирования пористых структур на основе кремния (por-Si) с осажденным Ag использовался метод электрохимического травления [5,6]. Установка для получения образцов пористого кремния состоит из cтеклоуглеродного тигля с электролитом, в который помещается образец.…”

Section: экспериментальная часть методика синтеза пористых структурunclassified

Внедрение Серебра В Матрицу Пористого Кремния Методом Электро-Термодиффузии

Koshevoi

Belоrus

Matyushkin

et al. 2019

kcmf

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В работе были проведены исследования возможности внедрения серебра в пористый кремний методом электро-термодиффузии и установлено влияние процедуры осаждения на адсорбционные свойства поверхности пористой матрицы. Композиты пористого кремния с внедренными частицами металла относятся к многофункциональным материалам и перспективны для применения в современной оптоэлектронике, сенсорике и персонализированной медицине. ИСТОЧНИК ФИНАНСИРОВАНИЯИсследование выполнено при поддержке РФФИ в рамках научного проекта 19-32-50038мол_нр «Исследование морфологических, физико-химических и оптических свойств матриц наоснове por-Si в зависимости от методов их формирования и функционализации». REFERENCES Raúl J. Martín-palma, Patrick D. McAtee, Rehab Ramadan, Akhlesh Lakhtakia. Hybrid nanostructured porous silicon-silver layers for wideband optical absorption. Scientifi c Reports, 2019, v. 9(1), p. 7291. https://doi.org/10.1038/s41598-019-43712-7 Kleps I., Miu M., Danila M., Simion M., Ignat T., Bragaru A., Dumitru L., Teodosiu G. Silver/porous silicon (PS) nanocomposite layers for biomedical applications. Proc. of “2006 International Semiconductor Conference”, 27-29 Sep., 2006, no. 9211112. https://doi.org/10.1109/SMICND.2006.283935 Ensafi A. A., Rezaloo F., Rezaei B. Electrochemical sensor based on porous silicon/silver nanocomposite for the determination of hydrogen peroxide. Sensors and Actuators B, 2016, v. 231, pp. 239–244. https://doi.org/10.1016/j.snb.2016.03.018 Jinjie Yin, Xiang Qi, Liwen Yang, Guolin Hao, Jun Li, Jianxin Zhong A hydrogen peroxide electrochemical sensor based on silver nanoparticles decorated silicon nanowire arrays. Electrochimica Acta, 2011, v. 56(11), pp. 3884–3889. https://doi.org/10.1016/j.electacta. 2011.02.033 Spivak Yu. M., Bespalova K. A., Belorus A. O., Panevin A. A., Somov P. A., Grigor’eva N. Yu., Chistyakova L. V., Zhuravskiy S. G., Moshnikov V. A. Sposob polucheniya i primer lekarstvennoy funktsionalizatsii poverkhnosti nanochastits poristogo kremniya [A method of obtaining and an example of drug functionalization of the surface of porous silicon nanoparticles]. Biotekhnosfera [Biotechnosphere], 2017 (3), pp. 69–75. (in Russ.) Pastukhov A. I., Belorus A. O., Bukina Ya. V., Spivak Yu. M., Moshnikov V. A. Infl uence of technology conditions on the surface energy of porous silicon using the method of contact angle. Proc. of “2017 IEEE Conference of Russian Young Researchers in Electrical and Electronic Engineering (EIConRus)”, 1–3 Feb., 2017, pp. 1183-1185. https://doi.org/10.1109/eiconrus.2017.7910770 Matyushkin L. B. Tekhnologiya i oborudovanie dlya polucheniya kolloidnykh kvantovykh tochek CsPbX3 (X = Cl, Br, I), CdSe/ZnS, plazmonnykh nanochastits Ag/SiO2 i gibridnykh struktur na ikh osnove [Technology and equipment for obtaining CsPbX3 colloidal quantum dots (X = Cl, Br, I), CdSe/ZnS, Ag/SiO2 plasmonic nanoparticles and hybrid structures based on them. Cand. Sci. (Eng.) diss. St. Petersburg, 2018, 138 p. URL: https://elibrary.ru/item.asp?id=35115356 (in Russ.) Permiakov N. V., Matyushkin L. B., Belorus A. O., Koshevoi V. L. Investigation of a program-controlled process of impregnation of porous semiconductors with silver nanoparticles to create an electrical contact. Proc. of “IEEE Conference of Russian Young Researchers in Electrical and Electronic Engineering (EIConRus)”, 2018, pp. 539–543. https://doi.org/10.1109/EICon- Rus.2018.8317154 Travkin P. G., Vorontsova N. V., Vysotsky S. A., Lenshin A. S., Spivak Yu. M., Moshnikov V. A. Issledovanie zakonomernostey formirovaniya struktury poristogo kremniya pri mnogostadiynykh rezhimakh elektrokhimicheskogo travleniya [Study of regularities of porous silicon structure formation with multistage modes of electrochemical etching]. Izvestiya SPBGETU LETI, 2011(4). pp. 3–9. (in Russ.) Belorus A. O., Komlev A. A. Certifi cate of state registration of computer programs No. 2014613394. Measurement of contact angle (MofCA) 26 March 2014. (in Russ.) Van Hoonacker A., Englebienne P. Revisiting silver nanoparticle chemical synthesis and stability by optical spectroscopy. Current Nanoscience, 2006, v. 2(4), pp. 359–371. https://doi.org/10.2174/157341306778699310 Girel K. V., Bondarenko A. V. Formirovanie nanostruktur serebra metodom immersionnogo osazhdeniya [Formation of silver nanostructures by immersion deposition method onto porous silicon and study of their optical properties]. Doklady BGUIR, 2014, v. 86(8), pp. 5–10. (in Russ.)

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Porous Silicon as a Nanomaterial for Disperse Transport Systems of Targeted Drug Delivery to the Inner Ear

Cited by 21 publications

References 24 publications

Study of Composite Structures Based on a Porous Silicon Matrix and Nanoparticles Ag/Zno Used as Non-Invasive Highly Sensitive Biosensor Devices

Study of Composite Structures Based on a Porous Silicon Matrix and Nanoparticles Ag/Zno Used as Non-Invasive Highly Sensitive Biosensor Devices

Fluorescent Nanoagents for Biomedical Applications

Внедрение Серебра В Матрицу Пористого Кремния Методом Электро-Термодиффузии

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