Porous poly(glycerol sebacate) (PGS) elastomer scaffolds for skin tissue engineering

Zhang, Xiaolan; Jia, Chuanlong; Qiao, Xiuying; Liu, Tianyi; Kim, Sun

doi:10.1016/j.polymertesting.2016.07.006

Cited by 44 publications

(55 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, a slight increase in the intensity of the peak was seen in Figure c, which would be due to the presence of more OH groups in the system by changing the ratios. Moreover, it is obvious that two sharp distinct peaks at 2,928 and 2,851 cm −1 , with no change in all samples, are attributed to methyl (–CH 3 ) and alkane (C–H) groups . Also, the stretching vibration of functional groups C═O and C–O, are 1,736 cm −1 and 1,180 cm −1 , respectively.…”

Section: Resultsmentioning

confidence: 95%

“…Bacterial infection and loss of water and electrolytes are such harmful results of skin wounds, which can endanger the whole body seriously . To repair large skin wounds, there is the tissue engineering approach available, which is based on a combination of a wide variety of synthetic and biological materials such as collagen, chitosan, poly(glycerol sebacate) (PGS), polyurethane, and in vitro‐cultured cells, as well as employing new techniques of fabricating scaffolds that mimic the structure and function of extracellular matrix (ECM) of tissues. In recent years, wound dressings have made tremendous progress, which closely resemble the normal skin and meet all the requirements of stimulating wound healing phases with minimum negative effects, such as the formation of scar tissue .…”

Section: Introductionmentioning

confidence: 99%

“…Ayati Najafabadi et al produced a wound dressing based on oxidized pectin and gelatin (Gel) with ability to release drug . Zhang et al porous‐fabricated PGS scaffolds as skin substitutes . Aoki et al prepared fibroblast growth factor‐embedded poly(lactic‐ co ‐glycolic acid) nanosheet for wound healing …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of sustained ciprofloxacin release of biodegradable electrospun gelatin/poly(glycerol sebacate) mat membranes for wound dressing applications

Najafabadi

Shirazaki

Kharazi

et al. 2018

Asia-Pacific J Chem Eng

View full text Add to dashboard Cite

In this research, gelatin and poly(glycerol sebacate) (PGS), which have demonstrated significantly developed wound healing process, were used to fabricate biodegradable and bioabsorbable membranes with controlled release of ciprofloxacin (CIP) as a powerful antibiotic. This was achieved by taking advantage of electrospinning technique to accelerate the wound healing as an extracellular matrix-liked composite membrane. We attempted to carefully investigate the impact of variable ratio of sebacic acid and glycerol as components of PGS and identified CIP-loaded cross-linked membrane (CIP-M 11 ) as an optimum membrane, although a significant change in structural properties of samples was not observed. The physicochemical properties of drug-loaded electrospun wound cover were evaluated by several characterization tests.Scanning electron microscopy and Fourier transform infrared spectroscopy results confirmed that CIP-embedded gelatin/PGS membrane was successfully synthesized and cross-linked properly. The CIP-M 11 sample showed a constant and uniform degradation rate with the capacity of durable drug release over the time period. The excellent antibacterial activity of CIP decreased the population of both Escherichia coli and Staphylococcus aureus bacteria and prevented bacterial infections. The cytocompatibility of membranes was completely proven by culturing L929 fibroblast cells on the prepared membranes. Finally, obtained results exhibit that the membranes should be considered as the promising wound dressing.

show abstract

Section: Resultsmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of sustained ciprofloxacin release of biodegradable electrospun gelatin/poly(glycerol sebacate) mat membranes for wound dressing applications

Najafabadi

Shirazaki

Kharazi

et al. 2018

Asia-Pacific J Chem Eng

View full text Add to dashboard Cite

show abstract

“…The conventional golden standard method so far is to treat those severe injuries by skin grafting. The limitations are not, however, only restricted to donor site shortage, scar formation, pain, tissue contracture, and other long‐term complications …”

Section: Introductionmentioning

confidence: 99%

“…The limitations are not, however, only restricted to donor site shortage, scar formation, pain, tissue contracture, and other long-term complications. 6 The healing process can be promoted by using biocompatible wound dressing materials. An ideal wound dressing should prevent dehydration of the wound and retain a favorable moist environment at the wound interface, allowing gas permeation as a barrier against dust and microorganisms.…”

Section: Introductionmentioning

confidence: 99%

Preparation and evaluation of poly glycerol sebacate/poly hydroxy butyrate core‐shell electrospun nanofibers with sequentially release of ciprofloxacin and simvastatin in wound dressings

Heydari

Varshosaz

Kharazi

et al. 2018

Polymers for Advanced Techs

View full text Add to dashboard Cite

Biodegradable wound dressing of poly glycerol sebacate/poly hydroxy butyrate was fabricated via the coaxial electrospinning process. Simvastatin and ciprofloxacin were loaded in the core and shell of the fibers, respectively. Scanning electron microscopy and transmission electron microscopy images showed a uniform core/shell structure. Introducing drugs into the polymers would cause the dressing samples to become more hydrophilic and degradation to occur faster. Drugs release would face no interventions, in which, approximately 60% of ciprofloxacin was released during the first 24 hours. Simvastatin exhibited a slower and controlled release behavior, with its release peak recorded after 2 days. The drug‐containing samples showed a proper bactericidal activity against both Gram‐positive and Gram‐negative bacteria. It may be concluded that the drug‐laden wound dressing fabricated in this study is capable of releasing the 2 drugs sequentially and that it is the ideal conditions for controlling infections and reducing wound healing duration.

show abstract

Poly(Glycerol Sebacate) in Biomedical Applications—A Review of the Recent Literature

Vogt

Ruther

Salehi

et al. 2021

Adv Healthcare Materials

102

View full text Add to dashboard Cite

Poly(glycerol sebacate) (PGS) continues to attract attention for biomedical applications owing to its favorable combination of properties. Conventionally polymerized by a two‐step polycondensation of glycerol and sebacic acid, variations of synthesis parameters, reactant concentrations or by specific chemical modifications, PGS materials can be obtained exhibiting a wide range of physicochemical, mechanical, and morphological properties for a variety of applications. PGS has been extensively used in tissue engineering (TE) of cardiovascular, nerve, cartilage, bone and corneal tissues. Applications of PGS based materials in drug delivery systems and wound healing are also well documented. Research and development in the field of PGS continue to progress, involving mainly the synthesis of modified structures using copolymers, hybrid, and composite materials. Moreover, the production of self‐healing and electroactive materials has been introduced recently. After almost 20 years of research on PGS, previous publications have outlined its synthesis, modification, properties, and biomedical applications, however, a review paper covering the most recent developments in the field is lacking. The present review thus covers comprehensively literature of the last five years on PGS‐based biomaterials and devices focusing on advanced modifications of PGS for applications in medicine and highlighting notable advances of PGS based systems in TE and drug delivery.

show abstract

Porous poly(glycerol sebacate) (PGS) elastomer scaffolds for skin tissue engineering

Cited by 44 publications

References 29 publications

Evaluation of sustained ciprofloxacin release of biodegradable electrospun gelatin/poly(glycerol sebacate) mat membranes for wound dressing applications

Evaluation of sustained ciprofloxacin release of biodegradable electrospun gelatin/poly(glycerol sebacate) mat membranes for wound dressing applications

Preparation and evaluation of poly glycerol sebacate/poly hydroxy butyrate core‐shell electrospun nanofibers with sequentially release of ciprofloxacin and simvastatin in wound dressings

Poly(Glycerol Sebacate) in Biomedical Applications—A Review of the Recent Literature

Contact Info

Product

Resources

About