Abstract:Purpose The objective of this study was to develop a population pharmacokinetic (popPK) model of anlotinib and to investigate the impact of various covariates in patients with malignant tumors.
Methods A total of 407 anlotinib plasma concentrations from 16 patients were analyzed in this study. Anlotinib was administered orally 12 or 16 mg in the single-dose phase and 12 mg once daily in the multiple-dose phase. PopPK model was established using nonlinear mixed-effects model (NONMEM) method. The potential influ… Show more
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