Population Attributable Risk of Hyperuricemia in Hypertension Incidence in 20-74-Year-Old Population during a 10-Year Longitudinal Cohort: Yazd Healthy Heart Cohort

Abstract

Background: The population attributable risk (PAR) percent has used widely in public health policy. We aimed to calculate the attribute risk of hypertension due to hyperuricemia by Levin's formulas compare to direct PAR calculation method.
 Methods: This was a sub-study of Yazd Healthy Heart Cohort (YHHC). Overall, 1256 normotensive individuals were enrolled through multistage randomized cluster sampling and followed up for mean 9.8 years, from 2005-2015. The threshold cutoff point of the hyperuricemia was considered equal and more than 75th percentile that equal to 5.5 mg/dl for men and 4.3mg/dl for women. To calculate the attributable risk of hyperuricemia in developing hypertension, two methods were applied. Levin's formulas and direct PAR estimation by population risk calculation via exposure prevalence weighted formula. Multiple logistic regression was used for estimate of odds ratio (OR) of hyperuricemia in developing hypertension. We calculated Relative Risk (RR) from OR. The data were analyzed using SPSS software version 16. A significant level of 0.05 was considered.
 Results: Hypertension developed in 44.7% of individuals with uric acid level ≥ 75th percentile vs. 35.6% of other individuals (P=0.024). Attributable risk (AR) of hyperuricemia in hypertension incidence was 9.1%. PAR of hyperuricemia for hypertension incidence by using two methods mentioned before was 6%, 5.8% respectively.
 Conclusion: The results of the study confirmed the noticeable contribution of hyperuricemia as an independent other risk factor for the occurrence of hypertension. PAR of hyperuricemia for hypertension incidence by using two methods almost near was 6%, 5.8% respectively.

The prevalence of hyperuricemia and its correlates in Zhuang nationality, Nanning, Guangxi Province

“…Research on the correlation between hyperuricemia and hypertension has a history of more than a century. There is increasing evidence that hyperuricemia is an independent risk factor for hypertension 31 . A prospective cohort of 539 patients aged 12–17 years with type 2 diabetes also confirmed that high UA increased the risk of hypertension in adolescents 32 .…”

“…There is increasing evidence that hyperuricemia is an independent risk factor for hypertension. 31 A prospective cohort of 539 patients aged 12-17 years with type 2 diabetes also confirmed that high UA increased the risk of hypertension in adolescents. 32 A Japanese cohort study involving 3584 adult patients with prehypertension found that the cumulative incidence of hypertension progression within 5 years in hyperuricemic patients was significantly higher than that in non-hyperuricemia patients.…”

A Prospective Study of Cigarette Smoking and Risk of 10-Years Incidence of Hypertension in men aged 20-74 years old; Yazd Healthy Heart Cohort Study (YHHC)

“…According to the JNC7 Guideline, hypertension is de ned as a systolic blood pressure ≥ 140, or a diastolic blood pressure ≥ 90, or taking antihypertensive drugs(28). We measured the blood pressure of our participants using a mercury sphygmomanometer in phase one and a digital sphygmomanometer, Omron Model, Japan in recent years (27,29,30).…”