Poor oral health is associated with coronary heart disease and elevated systemic inflammatory and haemostatic factors

Montebugnoli, Lucio; Servidio, Dora; Miaton, Romina Andrea; Prati, Carlo; Tricoci, Pierluigi; Melloni, Chiara

doi:10.1111/j.0303-6979.2004.00432.x

Cited by 107 publications

(111 citation statements)

References 41 publications

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“…results as this study that subjects who have periodontal infections, such as gingivitis and periodontitis have higher levels of CRP than subjects without gingivitis and periodontitis [11][12][13] respectively, supporting the hypothesis that these oral infections increase CRP levels, moreover, some intervention studies have also support this study results that periodontal treatment reduces CRP levels. 10,14 The results of the study showed that there was a 35% decrease in CRP level in periodontitis patients that used Dental Air Force home dental cleaning system without undergoing phase 1 (complete scaling and root planing) therapy.…”

Section: Ijedssupporting

confidence: 83%

A Clinical Study on Dental Air Force Home Dental Cleaning System on Adult Chronic Periodontitis Patients and its Assessment to C-Reactive Protein Levels

Vadvadgi¹,

Anarthe²,

Mani³

2012

International Journal of Experimental Dental Science

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Aim:The study was outlined to determine and assess the C-reactive protein (CRP) level in chronic periodontitis patients and to assess the CRP values after using Dental Air Force home dental cleaning system. Materials and methods:A total of 100 adult chronic periodontitis subjects were recruited voluntarily for this study. Clinical assessment of plaque index, gingival index, probing depth, clinical attachment level and C-reactive protein (CRP) levels were made prior to phase-1 therapy and at 7th and 15th day posttherapy. Effects of treatment were assessed by paired tests and analysis of variance by treatment group with baseline covariates. Comparative assessments were done among all the patients that were divided into four groups. Results:The results of this study showed that there was 35% decrease in CRP level in periodontitis patients that used Dental Air Force home dental cleaning system without undergoing phase 1 (complete scaling and root planing) therapy. There was 100% decrease in CRP in group D (phase 1 therapy followed by use of Dental Air Force home dental cleaning system) as compare to group C (phase 1 therapy followed by use of toothbrush) where there were 89.61% decrease in CRP level from baseline to 15th day of recordings.

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Section: Ijedssupporting

confidence: 83%

A Clinical Study on Dental Air Force Home Dental Cleaning System on Adult Chronic Periodontitis Patients and its Assessment to C-Reactive Protein Levels

Vadvadgi¹,

Anarthe²,

Mani³

2012

International Journal of Experimental Dental Science

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“…It has been observed that the serum levels of anti-oxLDL were significantly higher in CVD patients with greater severity of periodontal disease (Montebugnoli et al 2004(Montebugnoli et al , 2005, and Monteiro (Monteiro et al 2009) demonstrated that periodontitis patients' sera contain higher concentrations of antibodies against oxidized LDL than healthy controls. It has been proposed that oxLDL that is opsonized by antibodies such as anti-PC, anti-oxLDL and anti-CL, could promote systemic inflammation through interactions with DC's, which produce IL-12 and IL-18 leading to IFN-c production.…”

Section: Other Antibodiesmentioning

confidence: 99%

Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases

Schenkein

Loos

2013

Journal of Periodontology

174

120

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Inflammatory mechanisms linking periodontal diseases to cardiovascular diseasesSchenkein HA, Loos BG. Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases. AbstractAims: In this article, inflammatory mechanisms that link periodontal diseases to cardiovascular diseases are reviewed. Methods: This article is a literature review. Results: Studies in the literature implicate a number of possible mechanisms that could be responsible for increased inflammatory responses in atheromatous lesions due to periodontal infections. These include increased systemic levels of inflammatory mediators stimulated by bacteria and their products at sites distant from the oral cavity, elevated thrombotic and hemostatic markers that promote a prothrombotic state and inflammation, cross-reactive systemic antibodies that promote inflammation and interact with the atheroma, promotion of dyslipidemia with consequent increases in pro-inflammatory lipid classes and subclasses, and common genetic susceptibility factors present in both disease leading to increased inflammatory responses. Conclusions: Such mechanisms may be thought to act in concert to increase systemic inflammation in periodontal disease and to promote or exacerbate atherogenesis. However, proof that the increase in systemic inflammation attributable to periodontitis impacts inflammatory responses during atheroma development, thrombotic events or myocardial infarction or stroke is lacking.

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“…Oral health has not been seen as a priority in this group, although poor dental hygiene impacts on quality of life, affecting everyday functioning such as eating, comfort, appearance, social acceptance and self esteem, it is unlikely to be fatal (Cormac 1999). Poor oral health, however, has been linked to coronary heart disease (Montebugnoli 2004) and oral health is an important part of overall physical health. Many drugs routinely prescribed to those with serious mental illness lead to changes in physiology, some of which can be dangerous; the recognition of this has largely driven the monitoring of physical health symptoms in this client group.…”

Section: B a C K G R O U N D Description Of The Conditionmentioning

confidence: 99%

Oral health advice for people with serious mental illness

Khokhar

Ali

Jones

et al. 2010

Cochrane Database of Systematic Reviews

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Poor oral health is associated with coronary heart disease and elevated systemic inflammatory and haemostatic factors

Abstract: The present study suggests an association between poor oral status and CHD, and provides evidence that inflammatory and haemostatic factors could play an important role in this association.

Cited by 107 publications

References 41 publications

A Clinical Study on Dental Air Force Home Dental Cleaning System on Adult Chronic Periodontitis Patients and its Assessment to C-Reactive Protein Levels

A Clinical Study on Dental Air Force Home Dental Cleaning System on Adult Chronic Periodontitis Patients and its Assessment to C-Reactive Protein Levels

Inflammatory mechanisms linking periodontal diseases to cardiovascular diseases

Oral health advice for people with serious mental illness

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