2021
DOI: 10.3390/antiox10071117
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Abstract: The anticancer effect of pomegranate polyphenolic extract POMx in oral cancer cells has rarely been explored, especially where its impact on mitochondrial functioning is concerned. Here, we attempt to evaluate the proliferation modulating function and mechanism of POMx against human oral cancer (Ca9-22, HSC-3, and OC-2) cells. POMx induced ATP depletion, subG1 accumulation, and annexin V/Western blotting-detected apoptosis in these three oral cancer cell lines but showed no toxicity to normal oral cell lines (… Show more

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Cited by 17 publications
(19 citation statements)
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“…When antioxidant signaling is suppressed, ROS are generally developed. For example, pomegranate extract downregulated several antioxidant signaling pathways, enhancing oxidative stress, in oral cancer cells [ 50 ]. Accordingly, SK2 may downregulate the antioxidant signaling pathway, inducing ROS generation.…”
Section: Discussionmentioning
confidence: 99%
“…When antioxidant signaling is suppressed, ROS are generally developed. For example, pomegranate extract downregulated several antioxidant signaling pathways, enhancing oxidative stress, in oral cancer cells [ 50 ]. Accordingly, SK2 may downregulate the antioxidant signaling pathway, inducing ROS generation.…”
Section: Discussionmentioning
confidence: 99%
“…The antiproliferative effect of the pomegranate phenolic extract was also observed against human oral cancer. The extract triggered the dysfunction of the mitochondria by damaging their membrane potential and inducing the apoptotic mechanism [53] Chlorogenic acid is an interesting antioxidant molecule due to its wide spectrum of healthy effects on some pathologies, from diabetes to cardiovascular disease and cancer [54]. The oral administration of green coffee, particularly rich in chlorogenic acid, in hypertensive rats reduced the systolic blood pressure dose dependently without inducing any modification in the normotensive control group [55].…”
Section: Discussionmentioning
confidence: 99%
“…Drugs with oxidative stress accumulation ability may destroy redox homeostasis to kill cancer cells and become welcome chemical additions in anticancer therapy [44,45]. For example, pomegranate extract (POMx) [7], manoalide [26], sinuleptolide [31], cryptocaryone [32], 4beta-hydroxywithanolide E [33], and tenuifolide B [46], can generate oxidative stress and trigger apoptosis in oral cancer cells.…”
Section: Bura Shows Oxidative Stress In Oral Cancer Cellsmentioning
confidence: 99%
“…Several natural dietary products have anticancer effects [6,7]. Spices are also reported as potential anticancer sources [8][9][10][11][12].…”
Section: Introductionmentioning
confidence: 99%