Polyvinylidene fluoride–Hyaluronic acid wound dressing comprised of ionic liquids for controlled drug delivery and dual therapeutic behavior

Abednejad, Atiye; Ghaee, Azadeh; Morais, Eduarda S.; Sharma, Mukesh; Neves, Bruno Miguel; Freire, Mara G.; Nourmohammadi, Jhamak; Mehrizi, Ali Abouei

doi:10.1016/j.actbio.2019.10.007

Cited by 56 publications

(24 citation statements)

References 84 publications

(95 reference statements)

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“…However, due to the lack of statistic significant results between Etoreat and placebo administration, its further stage of development was suspended. In addition to this example, other dual-active API-ILs have been considered for improving transdermal delivery of analgesic and anti-inflammatory APIs in wound healing [206] Chantereau et al [203] later incorporated NSAID-based ILs also into BC membranes envisaging their use in transdermal drug delivery systems. These [Ch][NSAID] ILs allowed for increasing up to 100-fold the solubility of the respective NSAID precursors (ibuprofen, naproxen and ketoprofen) in aqueous media.…”

Section: Topical and Transdermal Drug Deliverymentioning

confidence: 99%

“…However, due to the lack of statistic significant results between Etoreat and placebo administration, its further stage of development was suspended. In addition to this example, other dual-active API-ILs have been considered for improving transdermal delivery of analgesic and anti-inflammatory APIs in wound healing [206]. Lidocainium naproxen ([Lid][Nap]), [Lid][Ibu], and lidocainium diclofenac ([Lid][Dicl]) were synthesized, which resulted in liquid mixtures at room temperature.…”

Section: Topical and Transdermal Drug Deliverymentioning

confidence: 99%

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The Role of Ionic Liquids in the Pharmaceutical Field: An Overview of Relevant Applications

Pedro

Freire

Silvestre

et al. 2020

IJMS

Self Cite

134

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Solubility, bioavailability, permeation, polymorphism, and stability concerns associated to solid-state pharmaceuticals demand for effective solutions. To overcome some of these drawbacks, ionic liquids (ILs) have been investigated as solvents, reagents, and anti-solvents in the synthesis and crystallization of active pharmaceutical ingredients (APIs), as solvents, co-solvents and emulsifiers in drug formulations, as pharmaceuticals (API-ILs) aiming liquid therapeutics, and in the development and/or improvement of drug-delivery-based systems. The present review focuses on the use of ILs in the pharmaceutical field, covering their multiple applications from pharmaceutical synthesis to drug delivery. The most relevant research conducted up to date is presented and discussed, together with a critical analysis of the most significant IL-based strategies in order to improve the performance of therapeutics and drug delivery systems.

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Section: Topical and Transdermal Drug Deliverymentioning

confidence: 99%

“…However, due to the lack of statistic significant results between Etoreat and placebo administration, its further stage of development was suspended. In addition to this example, other dual-active API-ILs have been considered for improving transdermal delivery of analgesic and anti-inflammatory APIs in wound healing [206]. Lidocainium naproxen ([Lid][Nap]), [Lid][Ibu], and lidocainium diclofenac ([Lid][Dicl]) were synthesized, which resulted in liquid mixtures at room temperature.…”

Section: Topical and Transdermal Drug Deliverymentioning

confidence: 99%

The Role of Ionic Liquids in the Pharmaceutical Field: An Overview of Relevant Applications

Pedro

Freire

Silvestre

et al. 2020

IJMS

Self Cite

134

View full text Add to dashboard Cite

show abstract

“…Cell adhesion of fibroblasts on HA-based membrane surfaces and cell viability evaluation confirmed enhanced viability and adhesion of fibroblasts on the membranes. Healing assay evaluated with fibroblasts demonstrated that the bilayer membranes containing API-ILs are not detrimental to wound healing [ 85 ].…”

Section: Bioactive Agents Loaded Hyaluronic Acid Scaffoldsmentioning

confidence: 99%

Hyaluronic Acid-Based Scaffolds as Potential Bioactive Wound Dressings

Alven

Aderibigbe

2021

Polymers

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The negative factors that result in delayed and prolonged wound healing process include microbial pathogens, excess wound exudates, underlying conditions, smoking, obesity, etc. Most of the currently used wound dressings demonstrate an inadequate capacity to treat wounds resulting from the factors mentioned above. The commonly used wound dressings include hydrogels, films, hydrocolloids, foams, fibers, sponges, dermal patches, bandages, etc. These wound dressings can be loaded with various types of bioactive agents (e.g., antibiotics, nanoparticles, anti-inflammatory drugs, etc.) to improve their therapeutic outcomes. Biopolymers offer interesting properties suitable for the design of wound dressings. This review article will be based on hyaluronic-acid-based scaffolds loaded with therapeutic agents for the treatment of wounds.

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“…Incorporation of lidocaine/NSAIDs-based dual-action ILs into polyvinylidene fluoride/hyaluronic acid-based membranes has also been addressed by Abednejad et al, who found (i) an up to 470-fold enhancement of the water solubility of the ILs as compared to the free APIs, (ii) improved release of the APIs from the IL-loaded membranes, (iii) suitability of the IL-loaded membranes for use as wound-dressings, (iv) enhanced membrane adhesion and viability of membrane-adhered fibroblasts, and (v) anti-inflammatory activity similar to that of the free APIs [ 139 ].…”

Section: Ionic Liquid-based Approaches In Dermal and Transdermal Drug Deliverymentioning

confidence: 99%

The Emerging Role of Ionic Liquid-Based Approaches for Enhanced Skin Permeation of Bioactive Molecules: A Snapshot of the Past Couple of Years

Gomes

Aguiar

Ferraz

et al. 2021

IJMS

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Topical and transdermal delivery systems are of undeniable significance and ubiquity in healthcare, to facilitate the delivery of active pharmaceutical ingredients, respectively, onto or across the skin to enter systemic circulation. From ancient ointments and potions to modern micro/nanotechnological devices, a variety of approaches has been explored over the ages to improve the skin permeation of diverse medicines and cosmetics. Amongst the latest investigational dermal permeation enhancers, ionic liquids have been gaining momentum, and recent years have been prolific in this regard. As such, this review offers an outline of current methods for enhancing percutaneous permeation, highlighting selected reports where ionic liquid-based approaches have been investigated for this purpose. Future perspectives on use of ionic liquids for topical delivery of bioactive peptides are also presented.

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Polyvinylidene fluoride–Hyaluronic acid wound dressing comprised of ionic liquids for controlled drug delivery and dual therapeutic behavior

Cited by 56 publications

References 84 publications

The Role of Ionic Liquids in the Pharmaceutical Field: An Overview of Relevant Applications

The Role of Ionic Liquids in the Pharmaceutical Field: An Overview of Relevant Applications

Hyaluronic Acid-Based Scaffolds as Potential Bioactive Wound Dressings

The Emerging Role of Ionic Liquid-Based Approaches for Enhanced Skin Permeation of Bioactive Molecules: A Snapshot of the Past Couple of Years

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