Polysulfone/amino-silanized poly(methyl methacrylate) dual layer hollow fiber membrane for uremic toxin separation

Abidin, Muhammad Nidzhom Zainol; Goh, Pei Sean; Said, Noresah; Ismail, Ahmad Fauzi; Othman, Mohd Hafiz Dzarfan; Abdullah, Mohd Sohaimi; Ng, Be Cheer; Hasbullah, Hasrinah; Kadir, Siti Hamimah Sheikh Abdul; Kamal, Fatmawati; Mansur, Sumarni

doi:10.1016/j.seppur.2019.116216

Cited by 25 publications

(20 citation statements)

References 42 publications

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“…The PSF does not have any vacant functional groups and in order to perform functionalization, additional functional groups must be added by grafting onto the aromatic rings, such as the introduction of a sulfonate group into the polymer structure through electrophilic substitution via sulfonation [ 47 ]. The addition of the sulfonic group increases the membrane’s permeability, hydrophilicity, hemocompatibility, anti-fouling behavior and antimicrobial properties [ 56 , 57 ]. The sulfonation treatment is capable of influencing the morphology of PSF membranes, such that neat PSF membranes have a smoother surface and sulfonated PSF presents a significant increase in the roughness of the surfaces [ 34 ].…”

Section: Polysulfone Functionalized Membranes For Hemodialysismentioning

confidence: 99%

“…Lately, the reduction of uremic toxin retention through functionalized PSF was studied [ 56 , 108 , 120 , 121 , 122 ]. The uremic toxins are organic or inorganic substances that are accumulated in the body fluids of patients with acute or chronic kidney disease and impaired kidney function [ 123 ].…”

Section: Polysulfone Functionalized Membranes For Hemodialysismentioning

confidence: 99%

“…Activated carbon, hydrated zirconium-oxide, hydrated zirconium-phosphate and activated aluminum silicate were used as the absorbent for removing uremic toxins [ 52 , 121 ]. Abidin et al [ 56 ] proposed a dual-layer hollow-fiber membrane based on PSF/amino-silanized poly(methyl methacrylate) for uremic toxin separation. These sandwich-structured membranes were formed by using two layers of PSF and polyvinylpyrrolidone (PVP), which is used for pore formation, and an outer layer from silanized PMMA with 3-(aminopropyl) triethoxysilane (APTES), for the introduction of adsorption properties to the composite membrane.…”

Section: Polysulfone Functionalized Membranes For Hemodialysismentioning

confidence: 99%

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Functionalized Hemodialysis Polysulfone Membranes with Improved Hemocompatibility

Radu

Voicu

2022

Polymers

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The field of membrane materials is one of the most dynamic due to the continuously changing requirements regarding the selectivity and the upgradation of the materials developed with the constantly changing needs. Two membrane processes are essential at present, not for development, but for everyday life—desalination and hemodialysis. Hemodialysis has preserved life and increased life expectancy over the past 60–70 years for tens of millions of people with chronic kidney dysfunction. In addition to the challenges related to the efficiency and separative properties of the membranes, the biggest challenge remained and still remains the assurance of hemocompatibility—not affecting the blood during its recirculation outside the body for 4 h once every two days. This review presents the latest research carried out in the field of functionalization of polysulfone membranes (the most used polymer in the preparation of membranes for hemodialysis) with the purpose of increasing the hemocompatibility and efficiency of the separation process itself with a decreasing impact on the body.

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Section: Polysulfone Functionalized Membranes For Hemodialysismentioning

confidence: 99%

Section: Polysulfone Functionalized Membranes For Hemodialysismentioning

confidence: 99%

Section: Polysulfone Functionalized Membranes For Hemodialysismentioning

confidence: 99%

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Functionalized Hemodialysis Polysulfone Membranes with Improved Hemocompatibility

Radu

Voicu

2022

Polymers

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“…Abidin and coauthors fabricated dual layer hollow fiber (DLHF) membranes consisting of a Polysulfone (PS) inner layer and a PS/amino-silanized poly(methyl methacrylate (N-PMMA) outer layer that exhibited a static adsorption capacity of up to 27.6 mg/g and 39.2% urea removal in dynamic filtration conditions [32]. The proposed process is that of combined membrane adsorption and filtration for the regeneration of dialysate.…”

Section: Polymeric Membranesmentioning

confidence: 99%

Mixed Matrix Membranes Adsorbers (MMMAs) for the Removal of Uremic Toxins from Dialysate

2022

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We developed Mixed Matrix Membrane Adsorbers (MMMAs) formed by cellulose acetate and various sorbent particles (activated carbon, zeolites ZSM-5 and clinoptilolite) for the removal of urea, creatinine and uric acid from aqueous solutions, to be used in the regeneration of spent dialysate water from Hemodialysis (HD). This process would allow reducing the disproportionate amount of water consumed and permits the development of closed-loop HD devices, such as wearable artificial kidneys. The strategy of MMMAs is to combine the high permeability of porous membranes with the toxin-capturing ability of embedded particles. The water permeability of the MMMAs ranges between 600 and 1500 L/(h m2 bar). The adsorption of urea, the limiting toxin, can be improved of about nine times with respect to the pure cellulose acetate membrane. Flow experiments demonstrate the feasibility of the process in a real HD therapy session.

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“…Amongst synthetic polymers used for the production of such membranes, polysulfone (PSF) remarks itself in virtue of its appropriate physico-chemical and biological properties such as good solubility in a large range of polar aprotic solvents, high thermal and mechanical resistance, chemical resistance on the entire range of pH and in oxidative medium, intrinsic biocompatibility, high permeability for low molecular weight proteins and high endotoxin retention ability [ 8 ]. Polysulfone-based membranes with increased hydrophilicity and ability to suppress hemodialysis-induced oxidative stress were developed by blending PSF with other polymers such as polyethylene glycol [ 15 ] chitosan [ 16 ] or amino-silanized poly(methyl methacrylate) [ 17 ] or by the incorporation of active compounds such as resveratrol [ 18 ], silibinin [ 19 ] or alpha lipoic acid [ 20 ] in the membranes structure.…”

Section: Introductionmentioning

confidence: 99%

A Novel Generation of Polysulfone/Crown Ether-Functionalized Reduced Graphene Oxide Membranes with Potential Applications in Hemodialysis

et al. 2021

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Heavy metal poisoning is a rare health condition caused by the accumulation of toxic metal ions in the soft tissues of the human body that can be life threatening if left untreated. In the case of severe intoxications, hemodialysis is the most effective method for a rapid clearance of the metal ions from the bloodstream, therefore, the development of hemodialysis membranes with superior metal ions retention ability is of great research interest. In the present study, synthetic polysulfone membranes were modified with reduced graphene oxide functionalized with crown ether, an organic compound with high metal ions complexation capacity. The physico-chemical characteristics of the composite membranes were determined by FT-IR, Raman, XPS and SEM analysis while their efficiency in retaining metal ions was evaluated via ICP-MS analysis. The obtained results showed that the thermal stability of reduced graphene oxide was improved after functionalization with crown ether and that the presence of the carbonaceous filler influenced the membranes morphology in terms of pore dimensions and membrane thickness. Moreover, the ability of Cu2+ ions retention from synthetic feed solution was up to three times higher in the case of the composite membranes compared to the neat ones.

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Polysulfone/amino-silanized poly(methyl methacrylate) dual layer hollow fiber membrane for uremic toxin separation

Cited by 25 publications

References 42 publications

Functionalized Hemodialysis Polysulfone Membranes with Improved Hemocompatibility

Functionalized Hemodialysis Polysulfone Membranes with Improved Hemocompatibility

Mixed Matrix Membranes Adsorbers (MMMAs) for the Removal of Uremic Toxins from Dialysate

A Novel Generation of Polysulfone/Crown Ether-Functionalized Reduced Graphene Oxide Membranes with Potential Applications in Hemodialysis

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