Polysaccharide of Atractylodes macrocephala Koidz alleviate lipopolysaccharide-stimulated liver inflammation injury of goslings through miR-223/NLRP3 axis

Chen, Feiyue; Li, Bingxin; Li, Wanyan; Chen, Wenbin; Huang, Yunmao; Tian, Yunbo; Yang, Baohe; Yuan, Mingfeng; Xu, Danning; Cao, Nan

doi:10.1016/j.psj.2022.102285

Cited by 5 publications

(2 citation statements)

References 52 publications

(53 reference statements)

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“…The results for the liver index in this study showed that LPS stimulation significantly increased the liver index of chickens, and that feeding Sihuang could effectively inhibit the increase in chicken liver index induced by LPS stimulation, and maintain the liver index at the same level as in the CON group. As an antigenic substance, LPS can cause liver damage in animals [31]. Shen et al [32] found, in the LPS-induced inflammation model test, that pathological changes and tissue swelling appeared in the liver tissue of chickens treated with LPS, which would cause liver weight, and be an important cause of an elevated liver index.…”

Section: Discussionmentioning

confidence: 99%

Effects of Sihuang Zhili Granules on the Diarrhea Symptoms, Immunity, and Antioxidant Capacity of Poultry Challenged with Lipopolysaccharide (LPS)

Wang

Zhang

et al. 2023

Antioxidants

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A growing interest has been focused on Chinese herbs as alternatives to antimicrobial growth promoters, which are characterized by non-toxic side effects and drug resistance. The purpose of this study was to evaluate the effects of the Sihuang Zhili granule (abbreviated as Sihuang) on diarrhea, immunity, and antioxidation in poultry. Thirty male Leghorn chickens, aged 21 days, were randomly assigned to one of three groups with ten animals each. The control group (CON) received intraperitoneal saline injections, while the LPS-challenged group (LPS) and Sihuang intervention group (SH) received intraperitoneal injections of LPS (0.5 mg/kg of BW) and Sihuang (5 g/kg) at d 31, d 33, d 35, respectively. The control and LPS groups were fed a basal diet, while the SH group was fed a diet supplemented with Sihuang from d 21 to d 35. Analysis of the diarrhea index showed that the addition of Sihuang inhibited the increase in the diarrhea grade and the fecal water content caused by LPS, effectively alleviating poultry diarrhea symptoms. The results of the immune and antioxidant indexes showed that Sihuang significantly reduced the contents of the pro-inflammatory factors TNF- α and IL-1 β, as well as the oxidative stress markers ROS and MDA. Conversely, it increased the contents of the anti-inflammatory factors IL-4 and IL-10, along with the activities of antioxidant enzymes GSH-Px and CAT, thereby enhancing the immune and antioxidant abilities of chickens. Furthermore, Sihuang protected the chicken’s ileum, liver, and immune organs from LPS invasion and maintained their normal development. In conclusion, this study confirmed the antidiarrheal effect of Sihuang in poultry farming and demonstrated its ability to improve poultry immunity and antioxidant capacity by modulating antioxidant enzyme activity and inflammatory cytokine levels.

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Section: Discussionmentioning

confidence: 99%

Effects of Sihuang Zhili Granules on the Diarrhea Symptoms, Immunity, and Antioxidant Capacity of Poultry Challenged with Lipopolysaccharide (LPS)

Wang

Zhang

et al. 2023

Antioxidants

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“… 115 Experimental studies have demonstrated that AMK polysaccharides alleviate LPS-induced inflammatory liver tissue injury and act as anti-hepatic injury agents by regulating the miR-223/NLRP3 axis, thus significantly reducing the expression levels of IL-1β and IL-18. 116 Additionally, Silibinin is an effective component of traditional Chinese medicine, used as a hepatoprotective agent in clinical therapy, and its phospholipid complex has been used in the clinical treatment of acute liver injury. 117 Further finding found that the Silibinin-phospholipid complex significantly diminished d-GalN/LPS-induced liver injury by enhancing the expression of miR-223-3p, and miR-223-3p directly targeted the 3’ UTR of NLRP3, thereby inhibiting the activation of the NLRP3 inflammasome and the expression of pyroptotic proteins to achieve hepatoprotective effects.…”

Section: Traditional Chinese Medicine and Its Active Ingredients Infl...mentioning

confidence: 99%

NcRNA Regulated Pyroptosis in Liver Diseases and Traditional Chinese Medicine Intervention: A Narrative Review

Deng,

Qin,

Qin

et al. 2024

JIR

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Pyroptosis is a novel pro-inflammatory mode of programmed cell death that differs from ferroptosis, necrosis, and apoptosis in terms of its onset and regulatory mechanisms. Pyroptosis is dependent on cysteine aspartate protein hydrolase (caspase)-mediated activation of GSDMD, NLRP3, and the release of pro-inflammatory cytokines, interleukin-1 (IL-1β), and interleukin-18 (IL-18), ultimately leading to cell death. Non-coding RNA (ncRNA) is a type of RNA that does not encode proteins in gene transcription but plays an important regulatory role in other post-transcriptional links. NcRNA mediates pyroptosis by regulating various related pyroptosis factors, which we termed the pyroptosis signaling pathway. Previous researches have manifested that pyroptosis is closely related to the development of liver diseases, and is essential for liver injury, alcoholic fatty liver disease (ALD), non-alcoholic fatty liver disease (NAFLD), liver fibrosis, and liver cancer. In this review, we attempt to address the role of the ncRNA-mediated pyroptosis pathway in the above liver diseases and their pathogenesis in recent years, and briefly outline that TCM (Traditional Chinese Medicine) intervene in liver diseases by modulating ncRNA-mediated pyroptosis, which will provide a strategy to find new therapeutic targets for the prevention and treatment of liver diseases in the future.

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An inulin-type polysaccharide from Atractylodis Macrocephalae Rhizoma can relieve psoriasis

Tang,

Liu,

et al. 2024

International Journal of Biological Macromolecules

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Polysaccharide of Atractylodes macrocephala Koidz alleviate lipopolysaccharide-stimulated liver inflammation injury of goslings through miR-223/NLRP3 axis

Cited by 5 publications

References 52 publications

Effects of Sihuang Zhili Granules on the Diarrhea Symptoms, Immunity, and Antioxidant Capacity of Poultry Challenged with Lipopolysaccharide (LPS)

Effects of Sihuang Zhili Granules on the Diarrhea Symptoms, Immunity, and Antioxidant Capacity of Poultry Challenged with Lipopolysaccharide (LPS)

NcRNA Regulated Pyroptosis in Liver Diseases and Traditional Chinese Medicine Intervention: A Narrative Review

An inulin-type polysaccharide from Atractylodis Macrocephalae Rhizoma can relieve psoriasis

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